Protein Alignment Sema4d and Sema1a

DIOPT Version :9

• Sequence 1: NP_001268809.1
• Gene: Sema4d / 20354
• MGIID: 109244
• Length: 861
• Species: Mus musculus
• Sequence 2: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Alignment Length: 566
• Identity: 188/566 - (33%)
• Similarity: 292/566 - (51%)
• Gaps: 78/566 - (13%)

Mouse    28 PRLTWEHGEVGLVQFHKPGIFNYSAL----LMSEDKDTLYVGAREAVFAVNALNISEKQHEVYWK 88
            |:|..|.|...:::|    :.|.|.:    |:::|.::|.:|||..||.::..::.|:|..| |.
  Fly    73 PKLYVELGPEDVLKF----VGNESVVDHFKLVTKDGNSLLIGARNTVFNLSIHDLVEQQRLV-WT 132

Mouse    89 VSEDKKSKCAEKGKSKQTECLNYIRVLQPLSSTSLYVCGTNAFQPTCDHLNLTSFKF-LGKSEDG 152
            ..||....|..|||.::. |.||||::...|...|:|||||:|:|.|:...::...: |..:::|
  Fly   133 SPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNG 196

Mouse   153 KGRCPFDPAHSYTSVMVGGELYSGTSYNFLGSEPIISRNSSHSPLRTE-YAIPWLNEPSFVFADV 216
            :..||:||.|:.|||:...||||||..:|.||:|||.|    .||:|| |....||.|:||.:..
  Fly   197 QAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR----EPLQTEQYDSLSLNAPNFVSSFT 257

Mouse   217 IQKSPDGPEGEDDKVYFFFTEVSVEYEFVFKLMIPRVARVCKGDQGGLRTLQKKWTSFLKARLIC 281
                      :.|.|||||.|.:||:....|.:..|||||||.|:||....:.:||||||:||.|
  Fly   258 ----------QGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNC 312

Mouse   282 SKP-DSGLVFNILQDVFVL---RAPGLKEPVFYAVFTPQLNNVGLSAVCAYTLATVEAVFSRGKY 342
            |.| |....||.:|....|   :...:...:.|.||....|::..|||||:.|..:...| .|::
  Fly   313 SIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTF-EGQF 376

Mouse   343 MQSATVEQSHTKWVRY-NGPVPTPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTP 406
            .:...:   ::.|:.. |..||.||||:| .:::||        |||.||.|:|.|.|||::|..
  Fly   377 KEQTGI---NSNWLPVNNAKVPDPRPGSC-HNDSRA--------LPDPTLNFIKTHSLMDENVPA 429

Mouse   407 IDNRPKLIKKDVNY--TQIVVD-RTQALDGTFYDVMFISTDRGALHKAV-------------ILT 455
            ..::|.|::....|  |||.|| :.:...|..|||:|:.||.|.:.|:|             ::.
  Fly   430 FFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVI 494

Mouse   456 KEVHVIEETQLFRDSEPVLTLLLSSKK------GRKFVYAGSNSGVVQAPLAFCEKHGSCEDCVL 514
            :|:.|:.:::..|:.|.|.|:.....|      |:..:...|....:|......:|..||.:||.
  Fly   495 EEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVA 559

Mouse   515 ARDPYCAWSPAIKACVTLHQEEASSRGWIQD-------MSGDTSSC 553
            .:||||||......|    :...:.| |:::       .:|..::|
  Fly   560 LQDPYCAWDKIAGKC----RSHGAPR-WLEENYFYQNVATGQHAAC 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema4d	NP_001268809.1	Sema_4D	31..501	CDD:200520	170/502 (34%)
		PSI	503..548	CDD:396154	14/51 (27%)
		Ig	563..646	CDD:416386
		Ig strand B	569..577	CDD:409353
		Ig strand C	583..589	CDD:409353
		Ig strand C'	591..594	CDD:409353
		Ig strand D	600..604	CDD:409353
		Ig strand E	607..614	CDD:409353
		Ig strand F	620..629	CDD:409353
		Ig strand G	633..646	CDD:409353
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	649..709
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	793..839
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	166/483 (34%)
		PSI	545..>579	CDD:214655	12/37 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910