Protein Alignment Sema4c and Sema2a

DIOPT Version :9

• Sequence 1: XP_006495867.1
• Gene: Sema4c / 20353
• MGIID: 109252
• Length: 943
• Species: Mus musculus
• Sequence 2: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Alignment Length: 636
• Identity: 203/636 - (31%)
• Similarity: 305/636 - (47%)
• Gaps: 93/636 - (14%)

Mouse   151 VRRFSQTGIQDFLTLTLTEHSGLLYVGAREALFAFSVEALEL----QGAISWEAPAEKKIECTQK 211
            ||.|: .|...:.|..:.|....|||||.:.:|..:::.:..    :..|:.|...:..:.|..|
  Fly    58 VREFN-CGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSK 121

Mouse   212 GKSNQTECFNFIRFLQPYN-SSHLYVCGTYAFQPKCTYINMLTFT-LDRAEFEDGKG----KCPY 270
            |||...:|.|.:|.:|..: ...||||||.|..|| .|:.....| |.|:|:..|.|    ||||
  Fly   122 GKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPK-DYVIYANLTHLPRSEYVIGVGLGIAKCPY 185

Mouse   271 DPAKGHTGLLVDG-------ELYSATLNNFLGTEPVILRYMGTHHSIK---------TEYLAFWL 319
            ||....|.:.|:.       .|||.|...|...:.||.|....:.|.|         .:|.:.||
  Fly   186 DPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWL 250

Mouse   320 NEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKW 384
            ::|:||||.    .:|.:      :||||.|.||||....:.|.:|:|||||.|:||...|...|
  Fly   251 DKPNFVGSF----DIGEY------VYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNW 305

Mouse   385 TTFLKARLVCS-APDWKVYFNQLKAVHTLRGASWHNTTFFGVFQARWGDMDLSAVCEYQLEQIQQ 448
            .|:|||||.|| :.::..|||::::|:.|..   ..:.||..|......:..||||.:.:.:||.
  Fly   306 ATYLKARLNCSISGEFPFYFNEIQSVYQLPS---DKSRFFATFTTSTNGLIGSAVCSFHINEIQA 367

Mouse   449 VFEGPYKEYSEQAQKWARYTDP-VPSPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEDQ 512
            .|.|.:||.|.....|....:. ||.||||:|:|:       ||:  |||..||||:.||||:..
  Fly   368 AFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVND-------TSN--LPDTVLNFIRSHPLMDKA 423

Mouse   513 VKPRLGRPLLVKKNTNFTHVVADRVPGLD--GATYTVLFIGTGDGWLLKAV-------SLGPWIH 568
            |......|:..|::..||.:|.|:: .:|  ...|.|.::||..|.:.|.|       ||.   .
  Fly   424 VNHEHNNPVYYKRDLVFTKLVVDKI-RIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLS---K 484

Mouse   569 MVEELQVFDQEPVESLVLSQSKKVLFAGSRSQLVQLSLADCT-KYRFCVDCVLARDPYCAWNVNT 632
            :::..:|...|.::.:.:||::|.|:.|:..::.|:.||.|. :|..|..||  |||||.|:...
  Fly   485 LLDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEA 547

Mouse   633 SRCVATTSGRSGSF-LVQHVANLDTSKMCNQYGIKKVRSIPKNITVVSGTDLVLPCHLS-----S 691
            :.|      |.... |:|.||| :||.:|:...:|      |.|.|..|..:.|.|.:.     .
  Fly   548 NTC------RPYELDLLQDVAN-ETSDICDSSVLK------KKIVVTYGQSVHLGCFVKIPEVLK 599

Mouse   692 NLAHAHWTFGSQDLPAEQ----PGSFLYDTGLQALVVMAAQSRHSGPYRCY 738
            | ....|...|:|....:    |..:: :|..:.|||::......|.|.|:
  Fly   600 N-EQVTWYHHSKDKGRYEIRYSPTKYI-ETTERGLVVVSVNEADGGRYDCH 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema4c	XP_006495867.1	Sema_4C	151..607	CDD:200519	161/492 (33%)
		PSI	608..>637	CDD:214655	12/29 (41%)
		Ig	673..757	CDD:386229	18/75 (24%)
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	157/483 (33%)
		Ig_Semaphorin_C	573..664	CDD:143180	19/84 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.870