DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZNF449 and trem

DIOPT Version :10

Sequence 1:NP_689908.3 Gene:ZNF449 / 203523 HGNCID:21039 Length:518 Species:Homo sapiens
Sequence 2:NP_650861.1 Gene:trem / 42392 FlyBaseID:FBgn0038767 Length:439 Species:Drosophila melanogaster


Alignment Length:469 Identity:115/469 - (24%)
Similarity:176/469 - (37%) Gaps:128/469 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    49 NKLWELCCQWLKPKMRSKEQILELLV------LEQFLTI---LPTEIETWVREHCPENR-ERVVS 103
            |:.|.:|...|......:|.:.::..      |:|.|.|   :|..::    ::.|:.. .:.|.
  Fly     6 NEKWVVCRVCLNNPSEGEELLHDIFSETASTRLDQMLHICAGIPVSLD----DNFPDKMCSKCVR 66

Human   104 LIEDLQRELEIPEQQVDMH--DMLLEELAPVGTAHIPPTMHLESPALQVMGPAQEAPVAEAWIPQ 166
            .:. |..:..:..|:...|  |||..|.:....|.       |...|.:........|.::|...
  Fly    67 CLR-LCYKFRLTCQRSHQHIMDMLDREASNANAAG-------EGDLLSIAEDLSVESVLKSWEDY 123

Human   167 AGPPELNYGATGECQNFLDPGYPLPKLDMNFSLENREE------PWVKELQDSKEMKQLLDSKIG 225
            |.                       :||....:|..|:      .:|.|..|:.:...       
  Fly   124 AS-----------------------QLDGGMKVEGEEDQQHQVITYVVEDGDTDDTNM------- 158

Human   226 FEIGIENEEDTSKQKKMETMYPFIVTLEGNALQGPILQKDYVQLENQWETPPEDLQ------TDL 284
            |::....:...::.::.||...:               ::|..|.|  |..||..|      ||:
  Fly   159 FDVHDPTQPVPNEIEEAETYAEY---------------EEYELLTN--ENSPEIAQEKGSTGTDV 206

Human   285 AKLVDQQNPTLGETPENSNLE---------EPLNPKPHK---------------------KKSPG 319
            |         ..|.||....|         :|.:.||.|                     ||..|
  Fly   207 A---------TEEPPEEEIAEDILDSDEDYDPTHAKPEKCDRSGRKPVAYHKNSPKVETFKKKVG 262

Human   320 EKPHR------CPQCGKCFARKSQLTGHQRIHSGEEPHKCPECGKRFLRSSDLYRHQRLHTGERP 378
            .||..      |..||..:..:::||.|.:.|||.:||:|..||:.|:::..|.||...|||.||
  Fly   263 RKPRNKLSTYICDVCGNIYPTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRP 327

Human   379 YECTVCKKRFTRRSHLIGHQRTHSEEETYKCLECGKSFCHGSSLKRHLKTHTGEKPHRCHNCGKS 443
            |:|..|...|..||....|.|.|::|..|.|..|.::|.:..:||.|...|||||||.|..|||.
  Fly   328 YKCNYCPAAFADRSTKTKHHRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKG 392

Human   444 FSRLTALTLHQRTH 457
            |.:...|.||:.||
  Fly   393 FVKAYKLRLHRETH 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF449NP_689908.3 SCAN 27..134 CDD:128708 19/96 (20%)
SFP1 <235..402 CDD:227516 56/208 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..325 13/68 (19%)
COG5048 <321..483 CDD:227381 59/143 (41%)
C2H2 Zn finger 325..345 CDD:275368 6/19 (32%)
C2H2 Zn finger 353..373 CDD:275368 7/19 (37%)
C2H2 Zn finger 381..401 CDD:275368 7/19 (37%)
C2H2 Zn finger 409..429 CDD:275368 6/19 (32%)
C2H2 Zn finger 437..457 CDD:275368 8/19 (42%)
C2H2 Zn finger 465..485 CDD:275368
zf-H2C2_2 477..502 CDD:463886
C2H2 Zn finger 493..513 CDD:275368
tremNP_650861.1 zf-AD 11..87 CDD:214871 13/80 (16%)
COG5048 <264..411 CDD:227381 59/143 (41%)
C2H2 Zn finger 274..294 CDD:275368 6/19 (32%)
C2H2 Zn finger 302..322 CDD:275368 7/19 (37%)
C2H2 Zn finger 330..350 CDD:275368 7/19 (37%)
C2H2 Zn finger 358..378 CDD:275368 6/19 (32%)
C2H2 Zn finger 386..406 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

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