Protein Alignment Sema4a and Sema1b

DIOPT Version :9

• Sequence 1: XP_006501250.1
• Gene: Sema4a / 20351
• MGIID: 107560
• Length: 798
• Species: Mus musculus
• Sequence 2: NP_001163178.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Alignment Length: 745
• Identity: 195/745 - (26%)
• Similarity: 309/745 - (41%)
• Gaps: 161/745 - (21%)

Mouse   106 LLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIPWPASERKKTECAFKKKSNETQCFNFIRVLV 170
            :|..:...:.|||::.:  .|:...|:..:.. :.|.:::..:..||.|.| :|..|.|::||..
  Fly    63 ILDHNDEFVLVGAKDVI--YNVSLNGLKEIAR-LEWHSTDADRELCALKGK-HEWDCHNYLRVYA 123

Mouse   171 SYNATHLYACGTFAFSPAC---TFIELQD--------SLLLPILIDKVMDGKGQSPFDPVHKHTA 224
            ......:..|||.::.|.|   |.:|:..        :..:...:.:.::.:|..|:.|.|..|.
  Fly   124 LRPNGEVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTY 188

Mouse   225 VLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDIF-LRWLHADASFVAAIPSTQVVYFFFEET 288
            ...||.|||.|:.:|.|.:|::.|     ..|:|:.: |:.|: ...||.||.....|.|||.|.
  Fly   189 AFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLN-QPDFVGAIERNGYVLFFFREL 247

Mouse   289 ASEFDFFEELYISRVAQVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLP-ADS 352
            :.|...|.:...||||:|||||.||.....|.||:||||:|.|:.||:.||.......:.| .:|
  Fly   248 SMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVES 312

Mouse   353 PSVSRIYAVFTSQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEV-SPRPGS 416
            .|.|.||||||:  .|.....||||||::.||...|.|::|......|.|......:| .||||.
  Fly   313 GSKSLIYAVFTT--SVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQ 375

Mouse   417 C--SMGPSSDKALTFMKDHFLMDEHVV---GTPLLVKSGVEY--TRLAVE-SARGLDGSSHVVMY 473
            |  .....:..|:.|:|:|.||:|.|.   |.|||.|..:.:  |.:||. ..:.|.|:.:.|:|
  Fly   376 CVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIY 440

Mouse   474 LGTSTGSLHK-----AVVPQDS----SAYLVEEIQLSPDSEPVRNLQLAPAQGAVFAGFSGGIWR 529
            .||..|.:.|     :..|..:    ...::.|:|:.|...|:|.|.::.::.::.....|.:..
  Fly   441 SGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVS 505

Mouse   530 VPRANCSVYESCVDCVLARDPHCAWDPESRLCSLLSGS-----TKPWKQDMERGNPEWVCTRGPM 589
            ||..:||....|:.|:..:||.||||.::..|..|:.|     ||.:.|.:
  Fly   506 VPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATSQHKFGTKTYLQSL-------------- 556

Mouse   590 ARSPRRQSPPQLIKEVLTVPNSILELPCPHLSALASYHWSHGRAKIS---------EASATVYN- 644
             .|.::.:                .|.|||:...|.     |...:|         |....:|:
  Fly   557 -NSTKKAA----------------ALLCPHIPRDAP-----GAETVSFVTMAPPPTEEQKLLYSN 599

Mouse   645 -----GSLLLLPQDGVG----GLYQCVATENGYSYPVVSYWVDSQD-QPLALDPELAGVPRERVQ 699
                 |:...|.|...|    ||.:...|.           :|..| .|...||:.:....:.::
  Fly   600 VGSSQGNQPSLEQQPTGGDDFGLNKITLTS-----------MDPDDIMPNLNDPQKSTASVDEIK 653

Mouse   700 VPLTRVGGGASMAAQRSYWPHFLIVTVLLAIVLLGVLTLLLASPLGALRARGKVQGCGMLPPREK 764
            ...|               |.|:::|.::      ..|.|:....|....:.|
  Fly   654 YAST---------------PSFMLLTTIV------FFTFLVGGIAGICCVKAK------------ 685

Mouse   765 APLSRDQHLQPSKDHRTSASDVDADNNHLG 794
               ||....|..:.||          ||.|
  Fly   686 ---SRLMEAQMDESHR----------NHFG 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema4a	XP_006501250.1	Sema	93..533	CDD:387663	141/457 (31%)
		PSI	534..578	CDD:214655	16/48 (33%)
		Ig	603..675	CDD:386229	16/90 (18%)
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	141/459 (31%)
		PSI	510..>537	CDD:214655	10/26 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910