DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema3f and Sema1b

DIOPT Version :9

Sequence 1:	XP_017168715.1	Gene:	Sema3f / 20350	MGIID:	1096347	Length:	820	Species:	Mus musculus
Sequence 2:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	208/729 - (28%)
Similarity:	322/729 - (44%)	Gaps:	149/729 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MLVTA--FILWASL----LTGAWPATPIQDQLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRI 59
            |||.|  .||..:|    :...|           .|.|:...:..:....|||..   |:|||..
  Fly    12 MLVNAIPMILLITLSGLTIVAGW-----------MPDVKPDLQTKQDKVLAHFIG---NSTDYFK 62

Mouse    60 LLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECILSGKDGNGECGNFVRLIQP 124
            :| |.:.:.:.||:||.:.::.|:.: :|...:.|.::....|.|.|.||. ..:|.|::|:...
  Fly    63 IL-DHNDEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYAL 124

Mouse   125 WNRTHLYVCGTGAYNPMCTYVNRGRRAQALPWTQMQVVRGRGSRATDGADRPTPTAPRQDYIFYL 189
            .....:.:|||.:|.|.|.:           :|.::|           :.....:|.....:.|.
  Fly   125 RPNGEVLLCGTNSYKPRCRH-----------YTPVEV-----------SSEEAGSAGHAHAMRYE 167

Mouse   190 EPEKLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLN 254
            ....:|: :|.|||.|..::..|..:..||:....||.|.|..|:|     ..:||:||:.:.||
  Fly   168 VSRDVEA-QGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR-----ENLRTEQYDLKQLN 226

Mouse   255 DPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDGGHCCLVNKWSTFL 318
            .|.|:.|      .|||...| |||||.|.|... ..|||:|:.|:|.||.||.......|::||
  Fly   227 QPDFVGA------IERNGYVL-FFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFL 284

Mouse   319 KARLVCSVPGEDGIETHFDELQDVFVQQTQDVRNPV--------IYAVFTSSGSVFRGSAVCVYS 375
            ||||.||||||  ...:|||:|.:         :|:        ||||||:|.:...|||||.::
  Fly   285 KARLNCSVPGE--FPFYFDEIQAI---------SPIVESGSKSLIYAVFTTSVNAIPGSAVCAFN 338

Mouse   376 MADIRMVFNGPFAHKEGPNYQWMPFS-GKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHP 439
            :.||...|:|.|..::.....|:|.. .::|.||||.|        ::.::......:||::.||
  Fly   339 VDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQC--------VEDSRTLTSIAVNFIKNHP 395

Mouse   440 LMYQAVYPLQRRPLVVRTGAPYRLTTVAV-DQVDAADGR-YEVLFLGTDRGTVQKVIVL----PK 498
            ||.:||..:..|||:.:....:|||.:|| .||.:..|. |:|::.|||.|.|.|.|.:    |.
  Fly   396 LMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPN 460

Mouse   499 DD-QEVEELMLEEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLAR 562
            .. ..::.:::.|::|.....|::.:.||:.:..|.|.|...:..:.||.| ::...|..|...:
  Fly   461 STVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHC-SHIVDCLGCLSLQ 524

Mouse   563 DPYCAWDGQA--CSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLE 625
            ||.||||.|.  |.....|..:                  |.:.....::.|.:     .||.|.
  Fly   525 DPICAWDLQTHECKNLATSQHK------------------FGTKTYLQSLNSTK-----KAAALL 566

Mouse   626 CQPRSPQATVKWLFQRDPSDRRREVSSCVLSPPPTPTPRGYAAPWIWEFFYSGESLREKCTSVAS 690
            | |..|         || :.....||...::||||...:         ..||...        :|
  Fly   567 C-PHIP---------RD-APGAETVSFVTMAPPPTEEQK---------LLYSNVG--------SS 603

Mouse   691 LG-QPSTGEAKAGG 703
            .| |||..:...||
  Fly   604 QGNQPSLEQQPTGG 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema3f	XP_017168715.1	Sema_3F	48..548	CDD:200515	158/516 (31%)
		PSI	547..584	CDD:214655	12/38 (32%)
		Ig	609..>650	CDD:386229	9/40 (23%)
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	158/515 (31%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910