DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema3f and Sema1a

DIOPT Version :9

Sequence 1:	XP_017168715.1	Gene:	Sema3f / 20350	MGIID:	1096347	Length:	820	Species:	Mus musculus
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	889	Identity:	225/889 - (25%)
Similarity:	372/889 - (41%)	Gaps:	253/889 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 FILWASLLTG---AWPATPIQDQLPATPRVRLSFKE-LKATGTA----HFFNFLLNTTDYRILLK 62
            |:|...|:.|   ||     |:.:.....|.|..:: ||..|..    ||            .|.
  Fly    53 FLLLTVLVIGNQSAW-----QENIRPKLYVELGPEDVLKFVGNESVVDHF------------KLV 100

Mouse    63 DEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECILSGKDGNGECGNFVRLIQPWNR 127
            .:|.:.:.:|:::.|.:|.:||:..:..:: |.:.....:.|::.|||... |.|::|::...:.
  Fly   101 TKDGNSLLIGARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSP 163

Mouse   128 THLYVCGTGAYNPMC-TYVNRGRRAQALPWTQMQVVRGRGSRATDGADRPTPTAPRQDYIFYLEP 191
            ..|:||||.::.||| ||:                                    ..|..:.||.
  Fly   164 GRLFVCGTNSFRPMCNTYI------------------------------------ISDSNYTLEA 192

Mouse   192 EKLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDP 256
            .|  :|:..|||||:.::.|.|.:.|||:|...||.|:|..|:|     ..::|:||:|..||.|
  Fly   193 TK--NGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR-----EPLQTEQYDSLSLNAP 250

Mouse   257 SFIHAELIPDSAERNDDKLYFFFRERSAEAPQ-NPAVYARIGRICLNDDGGHCCLVNKWSTFLKA 320
            :|:       |:....|.:||||||.:.|... ..|:|:|:.|:|..|.||.....|:|::|||:
  Fly   251 NFV-------SSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKS 308

Mouse   321 RLVCSVPGEDGIETHFDELQ---DVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMV 382
            ||.||:||:  ...:|:|:|   ::...|...:.:.:||.||.:..:...|||||.:::.||...
  Fly   309 RLNCSIPGD--YPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADT 371

Mouse   383 FNGPFAHKEGPNYQWMPF-SGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVY 446
            |.|.|..:.|.|..|:|. :.|:|.||||:|        ...::..||..:||::||.||.:.|.
  Fly   372 FEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------HNDSRALPDPTLNFIKTHSLMDENVP 428

Mouse   447 PLQRRPLVVRTGAPYRLTTVAVD-QVDAADGR-YEVLFLGTDRGTVQKVIVLPKDD--QEVEELM 507
            ....:|::|||...||.|.:||| |:....|: |:|:|:|||.|.:.|.:.....|  .:|..::
  Fly   429 AFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVV 493

Mouse   508 LEEVEVFKEPAPVKTMTISSKRQ------------QLYVASAVGVTHLSLHRCQAYG-AACADCC 559
            :||::|..:..|::.:.|....|            :|.:.:...|..:.||||.... .:|::|.
  Fly   494 IEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECV 558

Mouse   560 LARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFL 624
            ..:|||||||       ..:.|.||      ||.|
  Fly   559 ALQDPYCAWD-------KIAGKCRS------HGAP------------------------------ 580

Mouse   625 ECQPRSPQATVKWLFQRDPSDRRREVSSCVLSPPPTPTPRGYAAPWIWEFFYSGESLRE--KCTS 687
                       :||.:                                .:||...:..:  .|.|
  Fly   581 -----------RWLEE--------------------------------NYFYQNVATGQHAACPS 602

Mouse   688 VASLGQPSTGEAKAGGSLEFKASLVYRASSRSTP--------------PGLPRETQKNKKFRICT 738
                |:.::.:|.||....|:..:....|.|.:.              |.:..:. .|.::.:.|
  Fly   603 ----GKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADI-INAQYTVET 662

Mouse   739 LSGLYLLVWNITWVSSSIWKFCGYFLGK----------PSPCS-----------SSRGNAMRVSQ 782
            |. :.:|..:|  .|..:..|.|||.|:          |.|.:           :|..::.|:.|
  Fly   663 LV-MAVLAGSI--FSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQ 724

Mouse   783 LGILIKWKFCVRSKIFSFIVQKPRPPPPQP---------QPPGH 817
            ...|:..   |....::..|..|:||||..         :||.|
  Fly   725 EPKLLPQ---VEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMH 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema3f	XP_017168715.1	Sema_3F	48..548	CDD:200515	153/521 (29%)
		PSI	547..584	CDD:214655	12/37 (32%)
		Ig	609..>650	CDD:386229	2/40 (5%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	155/528 (29%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	15/46 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910