DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPB41 and HPF1

DIOPT Version :9

Sequence 1:	XP_011539258.1	Gene:	EPB41 / 2035	HGNCID:	3377	Length:	1031	Species:	Homo sapiens
Sequence 2:	NP_014487.1	Gene:	HPF1 / 854010	SGDID:	S000005515	Length:	967	Species:	Saccharomyces cerevisiae

Alignment Length:	486	Identity:	108/486 - (22%)
Similarity:	157/486 - (32%)	Gaps:	166/486 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   543 LDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKE----------TVKAEVK 597
            |||...|.|||              .:..|||....:|.| .|..:.:          |..||
Yeast   367 LDGDKYVFSAD--------------FIIHGGVFVEKSKPT-YPGTEFDISGENFDVSGTFNAE-- 414

Human   598 KEDEPPEQAEPEPTEAWKVEKTHIEVTVPTS---NGDQTQKLAEKTEDLIRMRKKKRERLDGENI 659
                     ||..:.|.....|      |.|   :||.:..|:|.|:              ||..
Yeast   415 ---------EPAASSASAYSFT------PGSFDNSGDISLSLSESTK--------------GEVT 450

Human   660 YIRHSNL-------------MLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTH 711
            :..:||.             .:..|.:..|....::..|: |:......|.||           .
Yeast   451 FSPYSNSGAFSFSNAILNGGSVSGLQRRAESGSVNNGEIN-LENGSTYVVVEP-----------V 503

Human   712 SPFRTLNI-------------NGQ--IPTGEGVKKTSVLPSERKVGGPESINGIRTE-EVAVVTK 760
            |...|:||             .||  :..||||  .:|.|:|... .|..:.|...| ::|:...
Yeast   504 SGSGTINIISGNLYLHYPDTFTGQTVVFKGEGV--LAVDPTETNT-TPIPVVGYTGENQIAITAD 565

Human   761 GPSTNPDSEWEGPKHSVVPSKSQMT-TSSESLQSFAFGSLSISSKETEEKEEGAAG----YLDIK 820
            ..:.:.||           :...:| |...|..||:.|: ..||......|...||    ||:.
Yeast   566 VTALSYDS-----------ATGVLTATQGNSQFSFSIGT-GFSSSGFNVSEGTFAGAYAYYLNY- 617

Human   821 EMPRGPTGGCIGVEEQASALKFSVTPASCQLQPGVKKAESSEEHVTPGEPPGKQNGSFLDFHVGN 885
                   ||.:     ||    |.||:|.....|...:.|..............:.||.....|:
Yeast   618 -------GGVV-----AS----SATPSSTSTTSGATNSTSGSTSFGASVTGSTASTSFGASVTGS 666

Human   886 QFPTLIRSFQPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGV 950
            ...|||..  .|.|.|.|:|.:                   |.|.|:....::|.|::|::
Yeast   667 TASTLISG--SPSVYTTTLTYA-------------------TTTSTVVVSCSETTDSNGNV---- 706

Human   951 LLTAQTITSETPSSTTTTQITKTVKGGISET 981
                .|||:..|.|:||..||...:.|...|
Yeast   707 ----YTITTTVPCSSTTATITSCDETGCHVT 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPB41	XP_011539258.1	B41	211..401	CDD:214604
		FERM_N	214..274	CDD:286467
		FERM_M	296..401	CDD:278785
		FERM_C_4_1_family	396..489	CDD:270005
		FA	499..541	CDD:285894
		SAB	667..713	CDD:282265	7/45 (16%)
		4_1_CTD	921..1027	CDD:283537	17/61 (28%)
HPF1	NP_014487.1	Hyphal_reg_CWP	337..617	CDD:403079	70/322 (22%)
HPF1	NP_014487.1	Herpes_BLLF1	<643..937	CDD:282904	28/120 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23280
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100