DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPB41 and epb41a

DIOPT Version :9

Sequence 1:	XP_011539258.1	Gene:	EPB41 / 2035	HGNCID:	3377	Length:	1031	Species:	Homo sapiens
Sequence 2:	XP_009292404.1	Gene:	epb41a / 559643	ZFINID:	ZDB-GENE-070705-81	Length:	670	Species:	Danio rerio

Alignment Length:	842	Identity:	458/842 - (54%)
Similarity:	553/842 - (65%)	Gaps:	192/842 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   210 MHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQ 274
            |||||.||||:::||.:|||||||||..:||:||||||:||:|||||:..|.|||||..|||::|
Zfish     1 MHCKVKLLDDSLFECELEKHAKGQDLFAKVCDHLNLLEKDYYGLAIWETPTIKTWLDFTKEIRRQ 65

Human   275 VRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGD 339
            ::|..::|||||||||||||||:||||||:||||||:||..|||||||.||||||||.:|||||:
Zfish    66 IQGTDYDFTFNVKFYPPDPAQLSEDITRYFLCLQLRKDIKNGRLPCSFVTLALLGSYALQSELGE 130

Human   340 YDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAK 404
            ||||:|..||..:.:|.|.||||||:||||||::||||:|||||:.||||||||:|||||||:||
Zfish   131 YDPEVHASDYAKELQLIPGQTKELEDKVMELHRTYRSMSPAQADMMFLENAKKLAMYGVDLHQAK 195

Human   405 DLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPS 469
            ||:||||:||||||||:||||||||||||||||||:|||||||||||||.:.|.|||.||||||:
Zfish   196 DLDGVDIMLGVCSSGLMVYKDKLRINRFPWPKVLKVSYKRSSFFIKIRPSDLEHYESAIGFKLPN 260

Human   470 YRAAKKLWKVCVEHHTFFRLTSTD--TIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFE 532
            |:|||||||||||||||||||||:  |.|: |||||||||||||||||||||||::||||||||:
Zfish   261 YKAAKKLWKVCVEHHTFFRLTSTEAATTPR-KFLALGSKFRYSGRTQAQTRQASSMIDRPAPHFQ 324

Human   533 RTASKRASRSLDGAAAVDSADRSPRPTSAP---AITQGQVAEGGVLD---ASAKKTVVPKAQKET 591
            |:.|||||||||| |.|.:.|::.||.|||   .|:.|.||...|..   :..|:|..|..:..:
Zfish   325 RSTSKRASRSLDG-AMVSTPDKNARPVSAPIMSPISPGDVAPSPVASGTRSDRKETSTPTGRLRS 388

Human   592 V--KAEVKKEDEPPEQAEPEPTEA---------WKVEKTHIEVTVPT-SNGDQTQKLAEKTEDLI 644
            .  |:||:.|....:.::...|:|         .:.|:.|.:..|.| :||::..:......:::
Zfish   389 TDRKSEVRAEAHVTDGSKTLSTKAEGTHEIKTVARRERRHRDAPVVTATNGERKSQSPRVDTEMV 453

Human   645 RMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLS 709
            |||||:.::::||.||||||||||||:||:|.||.:||.||||||::||||||||||||||||||
Zfish   454 RMRKKRAKKIEGETIYIRHSNLMLEDVDKTQTEIMRHHTSISELKRSFMESVPEPRPSEWDKRLS 518

Human   710 THSPFRTLNINGQIPTGEGVKKTSVLPSERKVGGPESINGIRTEEVAVVTKGPSTNPDSEWEGPK 774
            |||||||.:||||:                                         .|||
Zfish   519 THSPFRTASINGQM-----------------------------------------QPDS------ 536

Human   775 HSVVPSKSQMTTSSESLQSFAFGSLSISSKETEEKEEGAAGYLDIKEMPRGPTGGCIGVEEQASA 839

Zfish   537 ----------------------------------------------------------------- 536

Human   840 LKFSVTPASCQLQPGVKKAESSEEHVTPGEPPGKQNGSFLDFHVGNQFPTLIRSFQPPLVKTQTV 904
                                                                     |:|||:|:
Zfish   537 ---------------------------------------------------------PVVKTKTI 544

Human   905 TISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQ 969
            ||||..|:::|||.|||:|||||||||||||:|| .:...:.:.|:||:||||||||.|:|||||
Zfish   545 TISDVTNSLRSEIATKDIPIVHTETKTITYESAQ-PNALAEKESGMLLSAQTITSETVSTTTTTQ 608

Human   970 ITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 1031
            |||||||||||||||||||||||.:||||:.|.||||||||||||||||||||||||||..|
Zfish   609 ITKTVKGGISETRIEKRIVITGDTEIDHDKALAQAIKEAKEQHPDMSVTKVVVHQETEITPE 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPB41	XP_011539258.1	B41	211..401	CDD:214604	137/189 (72%)
		FERM_N	214..274	CDD:286467	40/59 (68%)
		FERM_M	296..401	CDD:278785	78/104 (75%)
		FERM_C_4_1_family	396..489	CDD:270005	80/92 (87%)
		FA	499..541	CDD:285894	36/41 (88%)
		SAB	667..713	CDD:282265	37/45 (82%)
		4_1_CTD	921..1027	CDD:283537	84/105 (80%)
epb41a	XP_009292404.1	B41	2..192	CDD:214604	137/189 (72%)
		FERM_N	5..66	CDD:286467	40/60 (67%)
		FERM_M	87..192	CDD:278785	78/104 (75%)
		FERM_C_4_1_family	187..280	CDD:270005	80/92 (87%)
		FA	291..333	CDD:285894	36/41 (88%)
		SAB	476..522	CDD:282265	37/45 (82%)
		4_1_CTD	561..666	CDD:283537	84/105 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I14966
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	906	1.000	Inparanoid score	I2785
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39450
OrthoDB	1	1.010	-	-		D104938at7742
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		oto52007
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9850
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	11	11.480