DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPB41 and Epb41

DIOPT Version :9

Sequence 1:	XP_011539258.1	Gene:	EPB41 / 2035	HGNCID:	3377	Length:	1031	Species:	Homo sapiens
Sequence 2:	XP_038967185.1	Gene:	Epb41 / 313052	RGDID:	1564762	Length:	1069	Species:	Rattus norvegicus

Alignment Length:	1035	Identity:	897/1035 - (86%)
Similarity:	936/1035 - (90%)	Gaps:	14/1035 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQ-TAAEGDNWCEQKLKASNGDTPTHE 64
            |||||||..||||||| ||||||.|.||||||.|.||:.| .||||.|..|||||||||||||||
  Rat    45 MTTEKSLAAEAENSQH-QKEEGEGATNSGQQESQLEEASQAAAAEGSNQGEQKLKASNGDTPTHE 108

Human    65 DLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILK 129
            ||||||||||||||||||.||||||||||||||||:||||::|||||.|||.|.||||||::|||
  Rat   109 DLTKNKERTSESRGLSRLLSSFLKRPKSQVSEEEGREVESEREKGEGEQKETELGTSLDEDVILK 173

Human   130 APIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAE 194
            |||||||||||||||||||||||.||||||||.|||||.|.|||||:||||..||||: |:|:||
  Rat   174 APIAAPEPELKTDPSLDLHSLSSIETQPAQEEHREDPDSETKEGEGIEECSGTEVKED-PESRAE 237

Human   195 TELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNA 259
            .|.:.||||||:||||||||||||||||||||||||||||||||||||||||||||||||:||:.
  Rat   238 REPETSQKPIRRHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAVWDST 302

Human   260 TSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFAT 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   303 TSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFAT 367

Human   325 LALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLEN 389
            ||||||||:|||||||||||||||||||||||||||:||||||||||||||||||||||||||||
  Rat   368 LALLGSYTVQSELGDYDPELHGVDYVSDFKLAPNQTRELEEKVMELHKSYRSMTPAQADLEFLEN 432

Human   390 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPG 454
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   433 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPG 497

Human   455 EQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQ 519
            |||.||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat   498 EQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTLPKSKFLALGSKFRYSGRTQAQTRQ 562

Human   520 ASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVV 584
            |||||||||||||||||||||||||||||.:|.||||||||||||.|.||.||.  .|.||
  Rat   563 ASALIDRPAPHFERTASKRASRSLDGAAAAESTDRSPRPTSAPAIAQSQVMEGP--GAPAK---- 621

Human   585 PKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKK 649
             ||.||.||.|.|:.:||.| .||||||||||||.|.|||||||||||.||||||.|||||||||
  Rat   622 -KAPKEAVKVEEKRGEEPAE-PEPEPTEAWKVEKPHTEVTVPTSNGDQAQKLAEKGEDLIRMRKK 684

Human   650 KRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPF 714
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   685 KRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPF 749

Human   715 RTLNINGQIPTGEGVKKTSVLPSERKVGGPESINGIRTEEVAVVTKGPSTNPDSEWEGPKHSVVP 779
            ||||||||:|||:||||||:||||||||||||:|||||||||.||:|||..|.||.|.||.||||
  Rat   750 RTLNINGQVPTGDGVKKTSILPSERKVGGPESVNGIRTEEVASVTQGPSAYPASERECPKQSVVP 814

Human   780 SKSQMTTSSESLQSFAFGSLSISS---KETEEKEEGAAGYLDIKEMPRGPTGGCIGVEEQASALK 841
            |:|.|||..||.|||..||||.:|   |||||||:||.|:|..:|.|.||.|.|:|||||||||.
  Rat   815 SESLMTTPPESPQSFGSGSLSKNSKEAKETEEKEQGAGGHLGAEERPTGPRGECLGVEEQASALS 879

Human   842 FSVTPASCQLQPGVKKAESSEEHVTPGEPPGKQNGSFLDFHVGNQFPTLIRSFQPPLVKTQTVTI 906
            |.|||||.||..|.:||:||||...|.|.|..|:|||||..||||||.|.|||||||||||||||
  Rat   880 FPVTPASRQLHLGGEKADSSEEPGAPAETPETQSGSFLDSPVGNQFPILTRSFQPPLVKTQTVTI 944

Human   907 SDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQIT 971
            ||.||||||||||||||||||||||||||||||:|::||||||||||||||||||.|||||||||
  Rat   945 SDTANAVKSEIPTKDVPIVHTETKTITYEAAQTEDSNGDLDPGVLLTAQTITSETTSSTTTTQIT 1009

Human   972 KTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE 1031
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||::|
  Rat  1010 KTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEISEE 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPB41	XP_011539258.1	B41	211..401	CDD:214604	184/189 (97%)
		FERM_N	214..274	CDD:286467	56/59 (95%)
		FERM_M	296..401	CDD:278785	102/104 (98%)
		FERM_C_4_1_family	396..489	CDD:270005	91/92 (99%)
		FA	499..541	CDD:285894	41/41 (100%)
		SAB	667..713	CDD:282265	45/45 (100%)
		4_1_CTD	921..1027	CDD:283537	101/105 (96%)
Epb41	XP_038967185.1	B41	254..444	CDD:214604	184/189 (97%)
		FERM_C_4_1_family	439..532	CDD:270005	91/92 (99%)
		FA	542..585	CDD:400882	42/42 (100%)
		SAB	702..750	CDD:398195	47/47 (100%)
		4_1_CTD	959..1065	CDD:399118	101/105 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83689407
Domainoid	1	1.000	319	1.000	Domainoid score	I14404
eggNOG	1	0.900	-	-		E1_KOG3530
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44324
Inparanoid	1	1.050	1482	1.000	Inparanoid score	I2803
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39450
OrthoDB	1	1.010	-	-		D104938at7742
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		oto136745
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9850
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	16.310