DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPB41 and frm-1

DIOPT Version :9

Sequence 1:	XP_011539258.1	Gene:	EPB41 / 2035	HGNCID:	3377	Length:	1031	Species:	Homo sapiens
Sequence 2:	NP_493601.2	Gene:	frm-1 / 173360	WormBaseID:	WBGene00001488	Length:	4648	Species:	Caenorhabditis elegans

Alignment Length:	860	Identity:	217/860 - (25%)
Similarity:	363/860 - (42%)	Gaps:	180/860 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   200 SQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWD-NATSKT 263
            ||:| |..:....||.|.|....|..|.|:::|:.|.::|...|::.|.:||.|..:| :..::.
Worm    16 SQQP-RDSKMQLAKVLLPDGVQKEFEVNKNSEGEALFRQVTRDLSIEEREYFSLCFYDKDEGTRH 79

Human   264 WLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALL 328
            ||.:.|.|.||::|:||.|:|.|||||..|..:.:|..|||:.||||:|::.||||.:..|.:||
Worm    80 WLYNDKNIAKQIKGLPWEFSFEVKFYPTTPTTIVDDHARYYVFLQLRRDLLTGRLPATADTHSLL 144

Human   329 GSYTIQSELGDYDPELHGVDYVSDF----KLAPN--QTKELEEKVMELHKSYRSMTPAQADLEFL 387
            ||:..|.|.||...|:  .|....|    ||.|:  ...|..:|:::||:..|..||::|:.:||
Worm   145 GSFVAQIEFGDAPAEM--TDAYEQFIVASKLVPSAQANPETYKKIVDLHREMRGQTPSEAENQFL 207

Human   388 ENAKKLSMYGVDLHKA---KDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 449
            ::.|.|::||:.|.||   ||.:.||:  |:.::|:.:|:|:.:.:.|.|..::||.|:|:.|.|
Worm   208 DHCKHLALYGIHLFKAISDKDKKPVDV--GIGAAGINIYQDEQKTHSFSWQNIIKIGYRRTYFSI 270

Human   450 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGS-KFRYSGRT 513
            |::.|..|:.|.|:.||||::.|||:.||..|||||||||...:......|...|| :|||.|||
Worm   271 KLKAGTVEKNEKTLYFKLPNHVAAKRTWKCAVEHHTFFRLIQPEDKTHKSFFNFGSQRFRYQGRT 335

Human   514 QAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDAS 578
            |.||:.||.:.|:|:                      :.||:|...|.|..|
Worm   336 QFQTKIASQMFDKPS----------------------TVDRAPSAMSQPIAT------------- 365

Human   579 AKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDL 643
                                       ||.:..:...:..:.:|           |:..|:....
Worm   366 ---------------------------AENQKLQTLNLTDSELE-----------QRQFERYRRA 392

Human   644 IRMRKKKRERLDGENI-------YIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRP 701
            :..:.....|.|.:.:       |.|.|.|::.......:: ..|..|.|            ||.
Worm   393 LTPKSYTSSRQDDDAVSTATFAKYSRPSTLLVVSTSGHHQQ-SPHELSYS------------PRG 444

Human   702 SEWDK------RLSTHSPFRTLNINGQIPTGEGVKKTSVLPSERKVGGPESINGIRTEEVAVVTK 760
            .:...      .:|..|..||.: :...|..|....||.:..|.:..|...:...:|...:..
Worm   445 DDSSNYSSAAYYMSERSSLRTPS-SAYYPPSEYTSPTSPVYFEGQHHGEYHVQMRQTASTSAT-- 506

Human   761 GPSTNPDSEWEGPKHSVVPSKSQMTTSSESLQSFAFGSLSISSKETEEKEEGAAGYLDIKEMPRG 825
            |||.:      |.:.::....|...:|..|..|...    :|..|..:..|.........|:|:.
Worm   507 GPSNS------GARRNLFGRASDARSSQASRDSVRL----VSFHEPVDPNEPIPNTYPYSELPQI 561

Human   826 PTGGCIGV------------EEQASALKF---SVTPAS-----CQLQP-------------GVKK 857
            |....:.|            .:|...|.:   :.||.:     ..|||             .|:.
Worm   562 PIERIVHVYHEGHYDRLSPRRQQRPELPYGFGNYTPRNGVSHVDNLQPDGEMDQQPIRFYVDVRH 626

Human   858 AESSEEHVT-----PGEPPGKQNGSFLDFHVGNQFPT-------LIRSFQPPLVKTQTVTISDNA 910
            :.:|..::.     ||:...|:.....|::......:       |.|..||..::..|.......
Worm   627 SGASRRNLAKRLSHPGKEDIKEQIDPKDYYFSASLASDPIHRTELSREVQPANIQQYTRRYHHGD 691

Human   911 NAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITS----ETPSSTTTTQIT 971
            :..|.:.|...: |.|.....:|....:...:|.:|:..:....|.:::    |:|.:....:::
Worm   692 SIHKPDTPQYRL-ITHVHPLAVTNRDGRDGQSSSNLNATISQREQVVSTKVRRESPDADRRVRLS 755

Human   972 KTV--KGGISETRIE 984
            .:|  .|.:::|..|
Worm   756 ASVDRSGNLTDTTEE 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPB41	XP_011539258.1	B41	211..401	CDD:214604	75/196 (38%)
		FERM_N	214..274	CDD:286467	19/60 (32%)
		FERM_M	296..401	CDD:278785	42/110 (38%)
		FERM_C_4_1_family	396..489	CDD:270005	42/95 (44%)
		FA	499..541	CDD:285894	16/42 (38%)
		SAB	667..713	CDD:282265	6/51 (12%)
		4_1_CTD	921..1027	CDD:283537	12/70 (17%)
frm-1	NP_493601.2	B41	27..221	CDD:214604	75/195 (38%)
		PH-like	216..310	CDD:388408	42/95 (44%)
		FA	321..357	CDD:370090	18/57 (32%)
		4_1_CTD	4542..4646	CDD:368659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161460218
Domainoid	1	1.000	96	1.000	Domainoid score	I5046
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138582at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850