Protein Alignment Sema3e and Sema1b

DIOPT Version :9

• Sequence 1: NP_035478.2
• Gene: Sema3e / 20349
• MGIID: 1340034
• Length: 775
• Species: Mus musculus
• Sequence 2: NP_001163178.1
• Gene: Sema1b / 37007
• FlyBaseID: FBgn0016059
• Length: 770
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 184/642 - (28%)
• Similarity: 296/642 - (46%)
• Gaps: 99/642 - (15%)

Mouse     7 ILTLLLWG-HLLELWTPGHSANPSYPRLRLSHKELLEL---NRTSIFQSPLGFLDLHTMLLDEYQ 67
            ||.:.|.| .::..|.|...     |.|:....::|..   |.|..|:           :||...
  Fly    20 ILLITLSGLTIVAGWMPDVK-----PDLQTKQDKVLAHFIGNSTDYFK-----------ILDHND 68

Mouse    68 ERLFVGGRDLVYSLNLERVSDGYREI---YWPSTAVKVEECIMKGKDANECANYIRVLHHYNRTH 129
            |.:.||.:|::|:::|    :|.:||   .|.||....|.|.:|||...:|.||:||........
  Fly    69 EFVLVGAKDVIYNVSL----NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGE 129

Mouse   130 LLTCATGAFDPHCA-FIRVGHHSEEP-------LFHLESHRSERGRGRCPFDPNSSFVSTLVGNE 186
            :|.|.|.::.|.|. :..|...|||.       ....|..|....:|.||:.|..:.........
  Fly   130 VLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGH 194

Mouse   187 LFAGLYSDYWGRDSAIFRSMGKLGHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKMYFFFTEK 251
            |::...:|:.|.|..|:|.     ::|||..|.:.|.:|.|||:.       ..:..:.|||.|.
  Fly   195 LYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAI-------ERNGYVLFFFREL 247

Mouse   252 ALEAENNAHTIYTRVGRLCVNDMGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLP 316
            ::|..|....:|:||.|:|.||.||.......|::||||||.|||||  ....||||::.:..:.
  Fly   248 SMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPG--EFPFYFDEIQAISPIV 310

Mouse   317 TRDPKNPVIFGLFNTTSNIFRGHAVCVYHMSSIREAFNGPYAHKEGPEYHWSLYE-GKVPYPRPG 380
            ....|: :|:.:|.|:.|...|.|||.:::..|..||:|.:..::..:.||...| .:||.||||
  Fly   311 ESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPG 374

Mouse   381 SCASKVNGGKYGTTKDYPDDAIRFARMHPLMYQPIKPVHKKPILVKTDGKYNLRQLAV-DRVEAE 444
            .|..        .::.....|:.|.:.||||.:.:..||.:|:|.|.:..:.|..:|| .:|::.
  Fly   375 QCVE--------DSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSL 431

Mouse   445 DG-QYDVLFIGTDTGIVLKVITIY----NQETEWMEEVILEELQIFKDPAPIISMEISSKRQQLY 504
            .| .|||::.|||.|.|.|.|.|.    |...:.::.|::.|:|:.....||..:.||:.:..|.
  Fly   432 SGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLV 496

Mouse   505 IGSASAVAQVRFHHCDMYGSACADC--CLA-RDPYCAWDGISCSRYYPTGAHAKRRFRRQDVRHG 566
            :.|..::..|..|||    |...||  ||: :||.||||                 .:..:.::.
  Fly   497 VVSDGSLVSVPLHHC----SHIVDCLGCLSLQDPICAWD-----------------LQTHECKNL 540

Mouse   567 NAAQQCFGQQFVGDALDRTEE----------RLAYGIESNSTLLECTPRSLQAKVIW 613
            ..:|..||.:....:|:.|::          |.|.|.|:.|.:....|.:.:.|:::
  Fly   541 ATSQHKFGTKTYLQSLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLY 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema3e	NP_035478.2	Sema_3E	49..519	CDD:200514	148/487 (30%)
		PSI	518..566	CDD:214655	13/50 (26%)
		Ig_Semaphorin_classIII	585..675	CDD:143279	8/39 (21%)
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	150/493 (30%)
		PSI	510..>537	CDD:214655	13/47 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910