DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema3c and Sema1b

DIOPT Version :10

Sequence 1:NP_038685.3 Gene:Sema3c / 20348 MGIID:107557 Length:751 Species:Mus musculus
Sequence 2:NP_611244.1 Gene:Sema1b / 37007 FlyBaseID:FBgn0016059 Length:770 Species:Drosophila melanogaster


Alignment Length:663 Identity:183/663 - (27%)
Similarity:307/663 - (46%) Gaps:105/663 - (15%)


- Green bases have known domain annotations that are detailed below.


Mouse     1 MAFRAICVLVGVFICSICVRGSSQPQARVYLTFDELRETKTSEYFSLSH---QQLDYRILLMDED 62
            |...||.:::.:.:..:.:.....|..:..|      :||..:.  |:|   ...|| ..::|.:
  Fly    12 MLVNAIPMILLITLSGLTIVAGWMPDVKPDL------QTKQDKV--LAHFIGNSTDY-FKILDHN 67

Mouse    63 QDRIYVGSKDHILSLNINNISQEPLSVFWPASTIKVEECKMAGKDPTH--GCGNFVRVIQTFNRT 125
            .:.:.||:||.|.::::|.: :|...:.|.::....|.|.:.||   |  .|.|::||.......
  Fly    68 DEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGK---HEWDCHNYLRVYALRPNG 128

Mouse   126 HLYVCGSGAFSPVCTYLNRGRRSEDQV----------FMIDSKCESGKGRCSFNPNVNTVSVMIN 180
            .:.:||:.::.|.|.:......|.::.          :.:....|: :|.|.::|..|:.....:
  Fly   129 EVLLCGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEA-QGLCPYSPAHNSTYAFAD 192

Mouse   181 EELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFK 245
            ..|:|....||.|.|..|:     |..:||:|::.|.|::|.||       |....:..|.|||:
  Fly   193 GHLYSATVADFSGGDPLIY-----RENLRTEQYDLKQLNQPDFV-------GAIERNGYVLFFFR 245

Mouse   246 ERLTDNNRSTKQIHSMIARICPNDTGGQRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFL 310
            |...:.....|.::|.:||:|.||.||..|....||:||||||.|||..|.  ..:|||::.:..
  Fly   246 ELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEF--PFYFDEIQAISP 308

Mouse   311 LETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPF-AHKEGPNHQLISYQGRIPYPR 374
            : .::...:|:|.:||||.:...|||||.:::.||...|:|.| :.|:..:|.|...:.::|.||
  Fly   309 I-VESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPR 372

Mouse   375 PGTCPGGAFTPNMRTTKDFPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAV-DRVN 438
            ||.|        :..::......|.||:|||||..::..:|.|||:.::...::.|.||| .:|.
  Fly   373 PGQC--------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVK 429

Mouse   439 AADGRYH-VLFLGTDRGTVQKVV-VLPTNSSASGE----LILEELEVFKNHVPITTMKISSKKQQ 497
            :..|.|: |::.|||.|.|.|.: :|.|:.:::.:    :::.|::|.....||..:.||:.|..
  Fly   430 SLSGAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNS 494

Mouse   498 LYVSSNEGVSQVSLHRC-HIYGTACADCCLARDPYCAWD--GHSCSRFYPTGKRRSRRQDVRHGN 559
            |.|.|:..:..|.||.| ||  ..|..|...:||.||||  .|.|.                  |
  Fly   495 LVVVSDGSLVSVPLHHCSHI--VDCLGCLSLQDPICAWDLQTHECK------------------N 539

Mouse   560 PLTQCRGFNLKAYRNAAEIVQYGVRNNST----FLEC------APKSPQASIKWLLQKDKDRRKE 614
            ..|....|..|.|..:.         |||    .|.|      ||.:...|...:.....:.:|.
  Fly   540 LATSQHKFGTKTYLQSL---------NSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKL 595

Mouse   615 VKLNERIIATSQG 627
            :..|   :.:|||
  Fly   596 LYSN---VGSSQG 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema3cNP_038685.3 Sema_3C 45..514 CDD:200512 145/491 (30%)
PSI 513..550 CDD:214655 13/39 (33%)
Ig_Sema3 574..664 CDD:409455 13/64 (20%)
Ig strand A 574..580 CDD:409455 0/5 (0%)
Ig strand B 585..593 CDD:409455 5/17 (29%)
Ig strand C 599..605 CDD:409455 1/5 (20%)
Ig strand C' 607..610 CDD:409455 0/2 (0%)
Ig strand D 619..623 CDD:409455 0/3 (0%)
Ig strand E 626..633 CDD:409455 2/2 (100%)
Ig strand F 639..648 CDD:409455
Ig strand G 651..664 CDD:409455
Sema1bNP_611244.1 Sema_1A 55..511 CDD:200498 143/484 (30%)
PSI 510..>537 CDD:214655 12/28 (43%)
Blue background indicates that the domain is not in the aligned region.

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