DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema3b and Sema1a

DIOPT Version :9

Sequence 1:	NP_001036244.1	Gene:	Sema3b / 20347	MGIID:	107561	Length:	749	Species:	Mus musculus
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	791	Identity:	228/791 - (28%)
Similarity:	345/791 - (43%)	Gaps:	153/791 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse    59 LVDEERGRLFVGAENHVASLSLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHTY 123
            ||.::...|.:||.|.|.:||:.::.:: ::|.|.:|.:..:.|...||| ...|.|:::::...
  Fly    99 LVTKDGNSLLIGARNTVFNLSIHDLVEQ-QRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVP 161

Mouse   124 NHTHLLACGTGAFHPTC-AFVEVGHRLEEPMLQLDRRKLEDGKGKTPYDPRHRAASVLVGEELYS 187
            :...|..|||.:|.|.| .::     :.:....|:..|  :|:...||||||.:.|||...||||
  Fly   162 SPGRLFVCGTNSFRPMCNTYI-----ISDSNYTLEATK--NGQAVCPYDPRHNSTSVLADNELYS 219

Mouse   188 GVTADLMGRDFTIFRSLGQNPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRESAVE 252
            |..||..|.|..|:|.     .|:||.:||..||.|.||..|       ...|.:||||||:|||
  Fly   220 GTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSF-------TQGDFVYFFFRETAVE 272

Mouse   253 AAPAMGRMSVSRVGQICRNDLGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLL---- 313
            .... |:...|||.::|:.|.||.....|:||:|||:||.||:|| :...:|:::|....|
  Fly   273 FINC-GKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG-DYPFYFNEIQSASNLVEGQ 335

Mouse   314 ----SSRDRQTPLLYAVFSTSSGVFQGSAVCVYSMNDVRRAFLGPFAHKEGPTHQWVSY-QGRVP 373
                ||:     |:|.||:|.|....|||||.:::.|:...|.|.|..:.|....|:.. ..:||
  Fly   336 YGSMSSK-----LIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVP 395

Mouse   374 YPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNPVLPMGGRPLFLQVGAGYTFTQIAADRV 438
            .||||.|       .:.::..||..:.|.:.|.||...|.....:|:.::....|.|||||.|..
  Fly   396 DPRPGSC-------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQ 453

Mouse   439 AAADG--HYDVLFIGTDVGTVLKVISVPKG-SRPNSEGLLLEELQVFEDSAAITSMQISSKRQ-- 498
            ....|  .|||:|:|||.|.::|.::.... |......:::||:.|...|..|.:::|....|
  Fly   454 IKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYD 518

Mouse   499 ----------QLYIASRSAVAQIALHRC-----TALGRACAECCLARDPYCAWD---GSACTRFQ 545
                      :|.|.:.|.|..|.||||     |    :|:||...:|||||||   |...:...
  Fly   519 QPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKIT----SCSECVALQDPYCAWDKIAGKCRSHGA 579

Mouse   546 PT-AKRRFRRQDIRNGDPSTLCSG--DSSHSVLLEKKVLGVESGSAFLECEPRS----LQAHVQW 603
            |. .:..:..|::..|..:...||  :|..:...|:|  |..:....|:...:|    :..::..
  Fly   580 PRWLEENYFYQNVATGQHAACPSGKINSKDANAGEQK--GFRNDMDLLDSRRQSKDQEIIDNIDK 642

Mouse   604 TFQG---AGEAAHTQVLAEERVERTARG---LLLRGL-------RR----QDSGVYLCVAVEQGF 651
            .|:|   :.:..:.|...|..|.....|   .||.|.       ||    :|..:.......:.|
  Fly   643 NFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYF 707

Mouse   652 SQPLRRLVLHVLSAA----------QAERLARAEEAAAPAPPGPKLWYRDFLQLVEP---GGGGG 703
            .|  |:.|....|:.          |.|.:..||....|.||.|...:.....|.:|   ....|
  Fly   708 EQ--RQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQG 770

Mouse   704 ANSLRMCRPQP-GH-----------------HSVAADSRRKG------------------RNRRM 732
            .||..:.:.|| |:                 |.|..|:.|:|                  |||.:
  Fly   771 PNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSL 835

Mouse   733 HVSELRAERGP 743
            .    ||.|.|
  Fly   836 G----RARRQP 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema3b	NP_001036244.1	Sema	46..516	CDD:417757	158/481 (33%)
		PSI	515..>551	CDD:214655	15/44 (34%)
		Ig	575..665	CDD:416386	21/110 (19%)
		Ig strand A	575..580	CDD:409353	1/4 (25%)
		Ig strand B	585..593	CDD:409353	1/7 (14%)
		Ig strand C	599..605	CDD:409353	0/5 (0%)
		Ig strand C'	607..610	CDD:409353	1/5 (20%)
		Ig strand D	620..624	CDD:409353	1/3 (33%)
		Ig strand E	627..634	CDD:409353	3/9 (33%)
		Ig strand F	640..649	CDD:409353	0/8 (0%)
		Ig strand G	652..665	CDD:409353	3/12 (25%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	158/481 (33%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/37 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920