Protein Alignment NRK and mig-15

DIOPT Version :10

• Sequence 1: NP_940867.2
• Gene: NRK / 203447
• HGNCID: 25391
• Length: 1582
• Species: Homo sapiens
• Sequence 2: NP_001024973.1
• Gene: mig-15 / 181248
• WormBaseID: WBGene00003247
• Length: 1096
• Species: Caenorhabditis elegans
• Alignment Length: 1617
• Identity: 428/1617 - (26%)
• Similarity: 632/1617 - (39%)
• Gaps: 594/1617 - (36%)

Human    14 DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKS 78
            ||..|.||.|||.|.:.:|.||||::|.|.|.||....|:|:||              :|:
 Worm    10 DLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMN--------------INE---- 56

Human    79 VGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSP--PGQRHQLWMVMELCAAGSVTDVV 141
                  |||::::.|:|:|:|:|.|:|:.::||||.|..|  .|:..|||:|||.|.:||:||:|
 Worm    57 ------DEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLV 115

Human   142 RMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTN 206
            :.|...||||:||||||||||:||.|||..:||||||||||||||.:|||||||||||||:.:|.
 Worm   116 KNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTV 180

Human   207 GRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILR 271
            ||||:|||||||||||||.|||.|..:||.|||:||:||||:|||||.||||::.|:.|||:|.|
 Worm   181 GRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPR 245

Human   272 ESAPTVK-SSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIK 335
            ...|.:| :..|::||..|:|...:|::..||.:..:|:|||:::..:|:.:..|:..|:..  .
 Worm   246 NPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDR--N 308

Human   336 KRQKK------------------------GIPLIFEREEAIKEQYTVRR-----------FRGPS 365
            :|.||                        ||....|....|....|:|:           |..|.
 Worm   309 RRVKKDDADYEYSGSEDDEPSPNNRGPSMGIRDDSESSSMIPMDNTLRKGFQKLQESSRGFAEPG 373

Human   366 CTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQALDSAPKPLK 430
             ..:|.|||......|.:.     .|.|::..|.|.....|:.:........|..:..|.|:|:.
 Worm   374 -AQQLRRLPQQPAPAPFQY-----QQSRYVEPRRESSEVKLRAVSSRGAADGPRHSPASRPRPVS 432

Human   431 GQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMPL---QAQVRAPRLLQ 492
            ...::||:...||.....|....|.:.|:..:.:.:     .|.|...||:   .|.|.||
 Worm   433 HHQRSPQQSHPAAPHLADLANYEKRRRSEREERRER-----ERQAHHAMPIARVSASVPAP---- 488

Human   493 VQSQVSKKQQAQTQTS--EPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQRHNQVPEQELEQNQA 555
               |.|:|.......:  :|:|||.:..|..               :....||   .:..|::.:
 Worm   489 ---QQSRKMSEPLLITHVKPEDLDVLASELS---------------KMGGHHN---GRSREESMS 532

Human   556 PEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLLPLHLDTQVLIPVEGQTEGSP 620
            |..|      |.|.:..:.:...:::.|                              |:.:...
 Worm   533 PPPP------APPPREASISSITDTIDV------------------------------GELDNGA 561

Human   621 QAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKK 685
            .|:...|:.....|      ||    .||.||    |||.|..|..||
 Worm   562 DAEWDDLKDIMMNG------EG----TLRGPN----KPLPPTPTDGEN----------------- 595

Human   686 SKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQ--VDKD 748
            :.||.:|:      :........:::.:|:                        .|:|.  :..|
 Worm   596 TLVSDVRR------NGNGNSGHGAYKGKKI------------------------PEIRPGIISLD 630

Human   749 KEDESSDNDEVFHSIQAEVQIEPL--KPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRS 811
            .:|..|||:|         ..|||  ||..::..:..:.:..|..|..:
 Worm   631 DDDSDSDNEE---------GNEPLMFKPINASSSRGALPDLLPKSPQLR---------------- 670

Human   812 LLEQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFK 876
                       ||.:.|.||    .|:..::|.:.:.|                  ..:.|:||:
 Worm   671 -----------RQINDQTRQ----MSDDRADESASLFG------------------SFYQPNGFQ 702

Human   877 VGKISPPVYLTNEWVGYNALSEIFRNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDDDESNDT 941
                                                                          |..
 Worm   703 --------------------------------------------------------------NSD 705

Human   942 FEDTYDHANGNDDLDNQVDQANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGY 1006
            ...:..|:..|
 Worm   706 SRSSIQHSFSN------------------------------------------------------ 716

Human  1007 DGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEE 1071
               |.:|:::.||        .||.|                          |.||..|.|
 Worm   717 ---RDREKSFVGY--------FGGGA--------------------------GAGGGTVNR---- 740

Human  1072 SGALGLNGEENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNAIDSGAAPSAPDHESDNKDISE 1136
                             ||  ||  ||...:|
 Worm   741 -----------------PG--RP--QDINQVQ--------------------------------- 751

Human  1137 SSTQSDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLI 1201
                    .|.:..|.|:....||                                      |.|
 Worm   752 --------VNVTPNSNGTPAENDA--------------------------------------PEI 770

Human  1202 HMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITIS 1266
            ..|:|:|:.||.|.:|||||||:||.|.|.|:||||:..:..||.||.|.|:.|||..|:|.|||
 Worm   771 RKYKKKFSGEILCAALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVLEGQNILATIS 835

Human  1267 GHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA-----------IDKLTGCEHFSVL 1320
            |.|.|:|||:|:|||.||              |:||.|..|           :..|.|..||.::
 Worm   836 GRKRRIRVYYLSWLRQKI--------------LRTEGAGSANTTEKRNGWVNVGDLQGAIHFKIV 886

Human  1321 QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPV 1385
            ::|...::.:.|:|||.:||||||                                       |.
 Worm   887 RYERIKFLVVGLESSIEIYAWAPK---------------------------------------PY 912

Human  1386 NRFKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPK 1450
            ::|         :..|.|.:|.|.|:.|||.:....|||:.:.|..|:|.||.:|..:.|:..|.
 Worm   913 HKF---------MSFKSFGSLSHVPLIVDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPA 968

Human  1451 NPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGW 1515
            ...:...|..|::||:..|:.::|.::.|.:.|....::.|.::..|.::|||:|:..|.:..||
 Worm   969 QSGQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVNTYGRMTKNVVLQWGEMPSSVAYISTGQIMGW 1033

Human  1516 GQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            |.||||:||:.:..|:.....:..:||:|||.|.||:||:|.......::|||||.|
 Worm  1034 GNKAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKVFFSSAKGGGSCQIYFMTLNK 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NRK	NP_940867.2	Protein Kinases, catalytic domain	18..313	CDD:473864	159/297 (54%)
		PRK10927	<386..>537	CDD:236797	32/155 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..579		15/88 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..859		10/75 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	926..1156		25/229 (11%)
		CNH	1218..1548	CDD:470577	112/340 (33%)
mig-15	NP_001024973.1	STKc_myosinIII_N_like	14..288	CDD:270785	159/297 (54%)
		CNH	773..1076	CDD:214481	125/364 (34%)