Protein Alignment NRK and mig-15

DIOPT Version :9

• Sequence 1: NP_940867.2
• Gene: NRK / 203447
• HGNCID: 25391
• Length: 1582
• Species: Homo sapiens
• Sequence 2: NP_001024973.1
• Gene: mig-15 / 181248
• WormBaseID: WBGene00003247
• Length: 1096
• Species: Caenorhabditis elegans
• Alignment Length: 1615
• Identity: 428/1615 - (26%)
• Similarity: 633/1615 - (39%)
• Gaps: 590/1615 - (36%)

Human    14 DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKS 78
            ||..|.||.|||.|.:.:|.||||::|.|.|.||....|:|:||              :|:
 Worm    10 DLNSLRDPAGIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMN--------------INE---- 56

Human    79 VGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSP--PGQRHQLWMVMELCAAGSVTDVV 141
                  |||::::.|:|:|:|:|.|:|:.::||||.|..|  .|:..|||:|||.|.:||:||:|
 Worm    57 ------DEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLV 115

Human   142 RMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTN 206
            :.|...||||:||||||||||:||.|||..:||||||||||||||.:|||||||||||||:.:|.
 Worm   116 KNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTV 180

Human   207 GRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILR 271
            ||||:|||||||||||||.|||.|..:||.|||:||:||||:|||||.||||::.|:.|||:|.|
 Worm   181 GRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPR 245

Human   272 ESAPTVK-SSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIK 335
            ...|.:| :..|::||..|:|...:|::..||.:..:|:|||:::..:|:.:..|:..|:..  .
 Worm   246 NPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDR--N 308

Human   336 KRQKK------------------------GIPLIFEREEAIKEQYTVRR-----------FRGPS 365
            :|.||                        ||....|....|....|:|:           |..|.
 Worm   309 RRVKKDDADYEYSGSEDDEPSPNNRGPSMGIRDDSESSSMIPMDNTLRKGFQKLQESSRGFAEPG 373

Human   366 CTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQALDSAPKPLK 430
             ..:|.|||......|.:.     .|.|::..|.|.....|:.:........|..:..|.|:|:.
 Worm   374 -AQQLRRLPQQPAPAPFQY-----QQSRYVEPRRESSEVKLRAVSSRGAADGPRHSPASRPRPVS 432

Human   431 GQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMPL---QAQVRAPRLLQ 492
            ...::||:...||.....|....|.:.|:..:.:.:     .|.|...||:   .|.|.||:
 Worm   433 HHQRSPQQSHPAAPHLADLANYEKRRRSEREERRER-----ERQAHHAMPIARVSASVPAPQ--- 489

Human   493 VQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQRHNQVPEQELEQNQAPE 557
             ||:...:....|.. :|:|||.:..|..               :....||   .:..|::.:|.
 Worm   490 -QSRKMSEPLLITHV-KPEDLDVLASELS---------------KMGGHHN---GRSREESMSPP 534

Human   558 QPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLLPLHLDTQVLIPVEGQTEGSPQA 622
            .|      |.|.:..:.:...:::.|                              |:.:....|
 Worm   535 PP------APPPREASISSITDTIDV------------------------------GELDNGADA 563

Human   623 QAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSK 687
            :...|:.....|      ||    .||.||    |||.|..|..||                 :.
 Worm   564 EWDDLKDIMMNG------EG----TLRGPN----KPLPPTPTDGEN-----------------TL 597

Human   688 VSTLRQALAKRLSPKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQ--VDKDKE 750
            ||.:|:      :........:::.:|:                        .|:|.  :..|.:
 Worm   598 VSDVRR------NGNGNSGHGAYKGKKI------------------------PEIRPGIISLDDD 632

Human   751 DESSDNDEVFHSIQAEVQIEPL--KPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLL 813
            |..|||:|         ..|||  ||..::..:..:.:..|..|..:
 Worm   633 DSDSDNEE---------GNEPLMFKPINASSSRGALPDLLPKSPQLR------------------ 670

Human   814 EQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVG 878
                     ||.:.|.||    .|:..::|.:.:.|                  ..:.|:||:
 Worm   671 ---------RQINDQTRQ----MSDDRADESASLFG------------------SFYQPNGFQ-- 702

Human   879 KISPPVYLTNEWVGYNALSEIFRNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDDDESNDTFE 943
                                                                        |....
 Worm   703 ------------------------------------------------------------NSDSR 707

Human   944 DTYDHANGNDDLDNQVDQANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDG 1008
            .:..|:..|
 Worm   708 SSIQHSFSN-------------------------------------------------------- 716

Human  1009 SRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESG 1073
             |.:|:::.||        .||.|                          |.||..|.|
 Worm   717 -RDREKSFVGY--------FGGGA--------------------------GAGGGTVNR------ 740

Human  1074 ALGLNGEENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNAIDSGAAPSAPDHESDNKDISESS 1138
                           ||  ||  ||...:|
 Worm   741 ---------------PG--RP--QDINQVQ----------------------------------- 751

Human  1139 TQSDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHM 1203
                  .|.:..|.|:....||                                      |.|..
 Worm   752 ------VNVTPNSNGTPAENDA--------------------------------------PEIRK 772

Human  1204 YEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGH 1268
            |:|:|:.||.|.:|||||||:||.|.|.|:||||:..:..||.||.|.|:.|||..|:|.||||.
 Worm   773 YKKKFSGEILCAALWGVNLLIGTDSGLMLLDRSGQGKVYPLISRRRFDQMTVLEGQNILATISGR 837

Human  1269 KNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA-----------IDKLTGCEHFSVLQH 1322
            |.|:|||:|:|||.||              |:||.|..|           :..|.|..||.::::
 Worm   838 KRRIRVYYLSWLRQKI--------------LRTEGAGSANTTEKRNGWVNVGDLQGAIHFKIVRY 888

Human  1323 EETTYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNR 1387
            |...::.:.|:|||.:||||||                                       |.::
 Worm   889 ERIKFLVVGLESSIEIYAWAPK---------------------------------------PYHK 914

Human  1388 FKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNP 1452
            |         :..|.|.:|.|.|:.|||.:....|||:.:.|..|:|.||.:|..:.|:..|...
 Worm   915 F---------MSFKSFGSLSHVPLIVDLTVEDNARLKVLYGSTGGFHAIDLDSAAVYDIYTPAQS 970

Human  1453 LEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQ 1517
            .:...|..|::||:..|:.::|.::.|.:.|....::.|.::..|.::|||:|:..|.:..|||.
 Worm   971 GQTTTPHCIVVLPNSNGMQLLLCYDNEGVYVNTYGRMTKNVVLQWGEMPSSVAYISTGQIMGWGN 1035

Human  1518 KAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            ||||:||:.:..|:.....:..:||:|||.|.||:||:|.......::|||||.|
 Worm  1036 KAIEIRSVDTGHLDGVFMHKKAQKLKFLCERNDKVFFSSAKGGGSCQIYFMTLNK 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NRK	NP_940867.2	PKc_like	18..313	CDD:304357	159/297 (54%)
		S_TKc	25..313	CDD:214567	154/290 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..579		15/86 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..859		10/75 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	926..1156		25/229 (11%)
		CNH	1213..1549	CDD:295303	114/346 (33%)
mig-15	NP_001024973.1	STKc_myosinIII_N_like	14..288	CDD:270785	159/297 (54%)
		S_TKc	21..288	CDD:214567	154/290 (53%)
		CNH	773..1076	CDD:214481	125/364 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	591	1.000	Inparanoid score	I587
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246443at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.070