Protein Alignment NRK and nrk

DIOPT Version :9

• Sequence 1: NP_940867.2
• Gene: NRK / 203447
• HGNCID: 25391
• Length: 1582
• Species: Homo sapiens
• Sequence 2: XP_031747384.1
• Gene: nrk / 100486469
• XenbaseID: XB-GENE-952099
• Length: 1237
• Species: Xenopus tropicalis
• Alignment Length: 1612
• Identity: 479/1612 - (29%)
• Similarity: 716/1612 - (44%)
• Gaps: 447/1612 - (27%)

Human    14 DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKS 78
            ||..|.:|.|||.|.:.:|.||||::|.|.|.|||...|:||||..:
 Frog    14 DLASLREPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMNVTE------------------ 60

Human    79 VGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRM 143
                  :|||:::.|:|:|:|||.|:||.::||||.:....||..|||:|||.|.||||||:|:.
 Frog    61 ------EEEEEIKLEINMLKKYSHHRNIATYYGAFVRKGLAGQDDQLWLVMEYCGAGSVTDLVKK 119

Human   144 TSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGR 208
            |.....|||||||||||:|:||||||||.||||||||||||||.||||||||||||||:.||.||
 Frog   120 TKGNCFKEDWIAYICREVLRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGR 184

Human   209 RNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRES 273
            ||:|||||||||||||.|||:|..:||||||:||:|||||||||||||||::.|:.|||:|.|..
 Frog   185 RNTFIGTPYWMAPEVIACDENPDSTYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP 249

Human   274 APTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQ 338
            .|.:||..||:|..||::.|.:||:..||::..:|:|.||||::||||:...|..||.   :.|:
 Frog   250 PPKLKSRKWSKKCINFVDSCLVKNYSHRPSTDTLLKHAFVRDLQNERHIRIMLKDHLD---RARK 311

Human   339 KKGIPLIFEREEAIKEQYTVRRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQV 403
            |||     |::|...|      :.|           :......|....||||
 Frog   312 KKG-----EKDENGYE------YSG-----------SEEEDDELNEDEGEPS------------- 341

Human   404 QALQQLQGAARVFMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAP 468
             ::..|.|.:.:                           .|.|:.||.:.|.::..|...|:: .
 Frog   342 -SIVNLPGESTL---------------------------RREFLRLQQENKNRSDPPRPQQLQ-Q 377

Human   469 PRLRRAARVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQG 533
            .:|:...:..|.|||:    |..:::.|..::::.:......:||.:..|.   |.:.||.:...
 Frog   378 QQLKDQEKYKMQLQAE----RQKRIEQQKEQRKKLEDYQRRERDLQKCQEY---QPKWPEMKEDA 435

Human   534 QAPEQQQRHNQVPEQE-------LEQNQAPE--------------QPEVQEQAAEPAQAETEAEE 577
            ::..:::...:..||:       .::|...:              :.||.:....|.:::|:.:.
 Frog   436 KSEGKKREDRKCAEQDRCLFNDAYDKNDRKQHENLKHKVDYGEKKKTEVSQHGGRPEESQTQKKF 500

Human   578 PESLRVNAQVFLPLLSQDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGS---VQAL 639
            ..:|..: |..|..|..||                          :...|||.:.|.:   |...
 Frog   501 HRTLPKD-QTQLLFLQHDH--------------------------KEKNLEPQRNISNHIPVGIS 538

Human   640 IEGLSRDLLRAPNSNNSKP--LGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
            :|...:....|..||...|  :.|..|.:.:.||:                |....||.:...|:
 Frog   539 LEMQEKKKTSADQSNIKWPVLMHPAHTRLGSGSSS----------------SPCTPALPRAALPE 587

Human   703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEV 767
                                                .|.||          |..|..:.|..:::
 Frog   588 ------------------------------------NENLR----------SSRDNHYSSSLSDM 606

Human   768 QIEPLKPYISN-----------PKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPID 821
            .|.||.|.:.:           |.|:.:  |:.|...|:|...|.:    .|..|:|.::||...
 Frog   607 AITPLTPGMDDVFWGAIINEEPPPKVPL--RTTSKFYNKDIQGHQR----CPSGSILHRSQKEQP 665

Human   822 IRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYL 886
            .:..||:.     :|..||          :|...|..|:.:.:||.:.|:|.
 Frog   666 EKSHSSRG-----SAGSSS----------QSNRIPSGSSKESQLLQNHHIPQ------------- 702

Human   887 TNEWVGYNALSEIFRNDWLTPAP----VIQP---------PEEDGDYVELYDASADTDGDDDDES 938
                         ||.....|.|    ::.|         |.....|   |.:|:|..|..||
 Frog   703 -------------FRKPENVPLPDAHKILSPSFIGRGKDSPHLKASY---YSSSSDEMGSSDD-- 749

Human   939 NDTFEDTYDHANGNDDLDNQVDQANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQ 1003
             |..:.....:||.:.|..::...             ..:....|..|.....:.|
 Frog   750 -DIQKKRKPLSNGMNVLRPRIPDG-------------VTEKPQRNILEEKVAEKQS--------- 791

Human  1004 DGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGD-QEEHAANIGSERRGSEGDGGKGVVR 1067
                                .:.:||..::...|..:.| .:.|
 Frog   792 --------------------CSNNHGIWSSYNQNYLLPDLLQSH--------------------- 815

Human  1068 TSEESGALGLNGEENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNA--IDSGAAPSAPDHESD 1130
             ..|:..:.....:||.......|...|... |.:|::....:.||.:  ||....|::|.
 Frog   816 -PPETSVIPHKTPQNCQALLNKSLNDQAPHG-ENVQQKNSSSSTASFSPFIDPRLLPASPP---- 874

Human  1131 NKDISESSTQSDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPA 1195
                             :|||..|.:|....|.            .|:.::.|.|||||..:.|.
 Frog   875 -----------------TSPSGCSPISKVEPFR------------RENARKGSVVNVNPTNIRPQ 910

Human  1196 CKKPLIHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLN 1260
            ...|.|..|:|:|.|||.|.:|||||||:||...|:|:||||:..:..||.||.|.|:.|||.||
 Frog   911 SDSPEIRKYKKKFNSEILCAALWGVNLLVGTEHGLWLLDRSGQGRVYPLISRRRFYQMDVLEGLN 975

Human  1261 LLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEET 1325
            :||||||.||:||||:|:|||||||.|||:.::||        ...::..|.||.|:.|:::|..
 Frog   976 ILITISGKKNKLRVYYLSWLRNKILRNDPDVEKRQ--------GWVSVGDLEGCVHYKVVKYERI 1032

Human  1326 TYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKR 1390
            .::.||||:|:.:||||||                                       |.::|
 Frog  1033 KFLVIALKNSVEVYAWAPK---------------------------------------PYHKF-- 1056

Human  1391 PDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEI 1455
                   :..|.|.:|.|||:.|||.:.:.:|||:.:.||.|:|.||.:|....|:.||.:....
 Frog  1057 -------MAFKSFSSLHHKPLFVDLTVENGQRLKVIYGSAVGFHAIDVDSGTAYDLYLPTHMQGN 1114

Human  1456 IIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAI 1520
            |.|..|||||:..|:.:::::..|.:.::...:..|:.:..|.::|:|:|:..:.:..|||:|||
 Frog  1115 IHPHAIIILPNTNGMELLVSYEDEGVYIDTYGRFTKETILQWGEMPASVAYLQSNQIMGWGEKAI 1179

Human  1521 EVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            |:||.::..||.....:..:||:|||.|.||:||:|......|::||||||:
 Frog  1180 ELRSGETGSLEGVFMHKKAQKLKFLCERNDKVFFSSVQSGGCSQIYFMTLGQ 1231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NRK	NP_940867.2	PKc_like	18..313	CDD:304357	170/294 (58%)
		S_TKc	25..313	CDD:214567	166/287 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..579		14/107 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..859		17/75 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	926..1156		34/232 (15%)
		CNH	1213..1549	CDD:295303	123/335 (37%)
nrk	XP_031747384.1	STKc_MAP4K4_6_N	8..289	CDD:270806	172/298 (58%)
		CNH	919..1215	CDD:214481	134/351 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246443at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920