DRSC/TRiP Functional Genomics Resources

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Protein Alignment EP300 and BDF2

DIOPT Version :10

Sequence 1:NP_001420.2 Gene:EP300 / 2033 HGNCID:3373 Length:2414 Species:Homo sapiens
Sequence 2:NP_010213.1 Gene:BDF2 / 851488 SGDID:S000002228 Length:638 Species:Saccharomyces cerevisiae


Alignment Length:769 Identity:162/769 - (21%)
Similarity:262/769 - (34%) Gaps:260/769 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   928 TAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQ-PEPAD 991
            :|.|..||.||..|:.        ||..|.||:..|:..:.....|..|   :.:.:|. |...|
Yeast    13 SALLAAPQSATANSRS--------SNSSSESSSNKNNINVGVGDDSGNV---SAVSIDDGPHFRD 66

Human   992 -----------------------------TQPEDISESKVEDCKMESTETEERSTE--LKTEIKE 1025
                                         ..|..||.:...:...|.....||.||  |:.|: |
Yeast    67 IFHYGHEENYKLASSGITNLNSSSHAHQTLSPISISNASTPESFPEHPLGLERETEPALEAEM-E 130

Human  1026 EEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYF 1090
            .|:.|          |.|||           .|:.:::|..|. .::.||.:||||..|.||.||
Yeast   131 AEELP----------PHQSK-----------YLLSSIKATKRL-KDARPFLKPVDPIALNIPHYF 173

Human  1091 DIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDP 1155
            :.|::|||||.|:.||....|....|...|...|.:|...:|...|.:.....::.:.||     
Yeast   174 NYVQTPMDLSLIETKLQGNVYHSVEQVTSDFKTMVDNCLNFNGPESSISSMAKRIQKYFE----- 233

Human  1156 VMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNE------IQGESVS 1214
                      :||...|..:         :|..|...:.:||..      ||      :...|||
Yeast   234 ----------KKLSAMPPRV---------LPASALKKTSRNRKK------NEDMDSPLVIRRSVS 273

Human  1215 LGDD------------PSQPQTTI----NKEQF-----SKRKNDTLDPELFVECTECGRKMHQIC 1258
            ..:|            ..:|:.||    :|:.|     ||.|:.||            :|..:.|
Yeast   274 TTNDNIGESGNREGVSGGRPKRTIHPPKSKDLFDIYENSKPKSKTL------------QKKFRTC 326

Human  1259 VLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLE-------NRVNDFLRRQNHP 1316
            :                  |..:.....|.|....|      ||:       |..|.|...:|..
Yeast   327 L------------------KILKVLMSKKNSDINFP------FLQPVDPIALNLPNYFDVVKNPM 367

Human  1317 ESGEVTVRVVHASDKTVEVKPGMKARFVD--------------SGEMAESFPYRTKALFAFEEID 1367
            :.|.::..:::...||::       :|||              .|....|...:.|.||.|..::
Yeast   368 DLGTISNNLMNWKYKTID-------QFVDDLNLVFYNCFQFNPEGNEVHSMGKKLKELFNFHWLE 425

Human  1368 GVDLCFFGMHVQEYGSDCPPPNQRRVYIS---YLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLG 1429
            ..|:    ::..|..||....|....|.|   |.|                       |.:.:..
Yeast   426 NQDI----LNEIETDSDLEEDNYSSSYSSDDEYDD-----------------------EDINEND 463

Human  1430 YTTGHIWACPPSEGDDYIFHCHPPDQKIPKPK-RLQEWYKKMLDKAVSER--------------I 1479
            .|...|         .|:      :||:.|.: .||:..::.|.|...||              :
Yeast   464 ITNPAI---------QYL------EQKLKKMEVELQQLKRQELSKLSKERKRKHLGKTLLRRKAM 513

Human  1480 VHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESI---KELEQEEEERKREENTSNESTDVT 1541
            .|...|:.|..|:    ...||...|.:....:::.|:   :.|...|:|.:.:.:..:|:| :.
Yeast   514 KHSVDDLKKSITD----KINELSDLEMNGMIRIIKNSLPADEILTSNEDEIEIDLDILDEAT-IA 573

Human  1542 KGDSKNAKKKNNKKTSKNKS---SLSRGNKKKPGMPNVSND--LSQKLYATMEK 1590
            :...:..:||||..:.:..|   |.:..||||..:..:..|  ::...|:..|:
Yeast   574 RIYERYFEKKNNNNSKRKLSGNYSTAPTNKKKKTLKFLEKDEIINNNNYSDSEE 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EP300NP_001420.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29
Interaction with RORA. /evidence=ECO:0000269|PubMed:9862959 2..149
Interaction with ALX1. /evidence=ECO:0000269|PubMed:12929931 2..139
Nuclear localization signal. /evidence=ECO:0000255 11..17
Med15 88..>318 CDD:312941
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 133..157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..235
zf-TAZ 347..414 CDD:460457
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..518
KIX 566..646 CDD:366953
Med15 <648..>854 CDD:312941
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 729..1050 35/153 (23%)
CRD1, mediates transcriptional repression 1017..1029 6/13 (46%)
Bromo_cbp_like 1051..1158 CDD:99927 32/106 (30%)
RING_CBP-p300 1170..1242 CDD:276805 21/98 (21%)
PHD_p300 1243..1277 CDD:277116 2/33 (6%)
HAT_KAT11 1306..1612 CDD:400497 63/325 (19%)
Interaction with histone. /evidence=ECO:0000269|PubMed:18273021 1397..1399 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1520..1578 15/60 (25%)
Binding region for E1A adenovirus 1572..1818 3/21 (14%)
ZZ_CBP 1668..1708 CDD:239077
zf-TAZ 1735..1803 CDD:460457
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1833..1924
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1980..2010
Med15 1984..>2408 CDD:312941
Creb_binding 1992..2098 CDD:462659
Interaction with HTLV-1 Tax 2003..2212
Interaction with NCOA2. /evidence=ECO:0000269|PubMed:15731352 2041..2240
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2094..2163
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2186..2237
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2267..2385
BDF2NP_010213.1 COG5076 55..378 CDD:227408 88/411 (21%)
Bromodomain <344..419 CDD:445827 16/87 (18%)
Lebercilin <472..>537 CDD:464776 16/74 (22%)
BET 521..576 CDD:435704 11/59 (19%)
Blue background indicates that the domain is not in the aligned region.

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