Protein Alignment EP300 and BDF1

DIOPT Version :10

• Sequence 1: NP_001420.2
• Gene: EP300 / 2033
• HGNCID: 3373
• Length: 2414
• Species: Homo sapiens
• Sequence 2: NP_013503.1
• Gene: BDF1 / 851115
• SGDID: S000004391
• Length: 686
• Species: Saccharomyces cerevisiae
• Alignment Length: 766
• Identity: 139/766 - (18%)
• Similarity: 233/766 - (30%)
• Gaps: 322/766 - (42%)

Human   955 PSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPAD--------------------------TQ 993
            |..:..:||...:     :.:|....|..:||.:|::                          :.
Yeast     6 PVQNDVDVNGNNV-----NDDVSSNLKRPIDQGDPSNGLAEEENPANNQLHLKKARLDGDALTSS 65

Human   994 PEDISESKVEDCKMES----------TETEERSTELKTE-----IKEE-------EDQPSTSATQ 1036
            |..::|:.:|...:.:          :..|:....||.|     .|:|       ::.|.....:
Yeast    66 PAGLAENGIEGATLAANGENGYNATGSGAEDEQQGLKKEEGGQGTKQEDLDENSKQELPMEVPKE 130

Human  1037 SSPAPGQSKKKIFKPE------ELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKS 1095
            .:|||.........|:      :.:.||: .::|:.|. .::.||.|||||..|.||.||:.:|.
Yeast   131 PAPAPPPEPDMNNLPQNPIPKHQQKHALL-AIKAVKRL-KDARPFLQPVDPVKLDIPFYFNYIKR 193

Human  1096 PMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFE--------QE 1152
            |||||||:|||:.|.|:.|.|..:|..||.||:..:|...:.:.:....:...||        ::
Yeast   194 PMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNAGISQMARNIQASFEKHMLNMPAKD 258

Human  1153 IDPVMQSLGYCCGRK---LEFSP------QTLCCYGKQLCTIPRDATYYSYQNR----------Y 1198
            ..||:..     ||:   .|.:|      ||.....|:....|:....|.|:::          .
Yeast   259 APPVIAK-----GRRSSAQEDAPIVIRRAQTHNGRPKRTIHPPKSKDIYPYESKKPKSKRLQQAM 318

Human  1199 HFCEKCFNEIQGESVSLGD----DPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICV 1259
            .||:....|:..:..:..:    :|..| .::|...:.....:.:|
Yeast   319 KFCQSVLKELMAKKHASYNYPFLEPVDP-VSMNLPTYFDYVKEPMD------------------- 363

Human  1260 LHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVR 1324
                                                  ||| :..::||:  :....|..|..||
Yeast   364 --------------------------------------LGT-IAKKLNDW--QYQTMEDFERDVR 387

Human  1325 VVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPN 1389
            :|.                              |..:.|.. ||..:...|..::|
Yeast   388 LVF------------------------------KNCYTFNP-DGTIVNMMGHRLEE--------- 412

Human  1390 QRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPD 1454
                         .|..|                            ||..|:. |||
Yeast   413 -------------VFNSK----------------------------WADRPNL-DDY-------- 427

Human  1455 QKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNV------- 1512
                             |.....|...||.|.             |..|.|.|....:
Yeast   428 -----------------DSDEDSRTQGDYDDY-------------ESEYSESDIDETIITNPAIQ 462

Human  1513 -LEESIKELEQEEEERKREE-NTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKK------ 1569
             |||.:..::.|.::.|::| ....:...:.:|..|..|:...:..|||.||..|.:||
Yeast   463 YLEEQLARMKVELQQLKKQELEKIRKERRLARGSKKRGKRSKGRSGSKNASSKGRRDKKNKLKTV 527

Human  1570 ----------------------------KPGMPNVSNDLSQKL-YATMEKH 1591
                                        |..|||:|.|...:| ..|::.|
Yeast   528 VTYDMKRIITERINDLPTSKLERAIDIIKKSMPNISEDDEVELDLDTLDNH 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EP300	NP_001420.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Interaction with RORA. /evidence=ECO:0000269|PubMed:9862959	2..149
		Interaction with ALX1. /evidence=ECO:0000269|PubMed:12929931	2..139
		Nuclear localization signal. /evidence=ECO:0000255	11..17
		Med15	88..>318	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..157
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235
		zf-TAZ	347..414	CDD:460457
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..518
		KIX	566..646	CDD:366953
		Med15	<648..>854	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	729..1050		21/142 (15%)
		CRD1, mediates transcriptional repression	1017..1029		5/23 (22%)
		Bromo_cbp_like	1051..1158	CDD:99927	42/120 (35%)
		RING_CBP-p300	1170..1242	CDD:276805	14/91 (15%)
		PHD_p300	1243..1277	CDD:277116	0/33 (0%)
		HAT_KAT11	1306..1612	CDD:400497	56/330 (17%)
		Interaction with histone. /evidence=ECO:0000269|PubMed:18273021	1397..1399		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1520..1578		18/92 (20%)
		Binding region for E1A adenovirus	1572..1818		8/21 (38%)
		ZZ_CBP	1668..1708	CDD:239077
		zf-TAZ	1735..1803	CDD:460457
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1833..1924
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1980..2010
		Med15	1984..>2408	CDD:312941
		Creb_binding	1992..2098	CDD:462659
		Interaction with HTLV-1 Tax	2003..2212
		Interaction with NCOA2. /evidence=ECO:0000269|PubMed:15731352	2041..2240
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2094..2163
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2186..2237
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2267..2385
BDF1	NP_013503.1	COG5076	1..373	CDD:227408	83/437 (19%)
		Bromodomain	<339..417	CDD:445827	21/191 (11%)
		PTZ00108	<386..647	CDD:240271	52/313 (17%)
		BET	527..589	CDD:435704	9/52 (17%)