Protein Alignment EP300 and ep300

DIOPT Version :10

• Sequence 1: NP_001420.2
• Gene: EP300 / 2033
• HGNCID: 3373
• Length: 2414
• Species: Homo sapiens
• Sequence 2: XP_004913855.2
• Gene: ep300 / 734023
• XenbaseID: XB-GENE-482293
• Length: 2492
• Species: Xenopus tropicalis
• Alignment Length: 2558
• Identity: 1830/2558 - (71%)
• Similarity: 2014/2558 - (78%)
• Gaps: 210/2558 - (8%)

Human     1 MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQ 65
            ||||:|:|||||||:||:|||:|  |:||..|||||||||.|||||||||:|.|||||||::||.
 Frog     1 MAENLVDPGPPSAKKPKMSSPSL--SSSDVPDFGSLFDLEQDLPDELINSSEFGLTNGGDLSQLH 63

Human    66 TSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAG 130
            .|:.||.|||:||||||||||.|::.|::||:|       .|..|:|||:.|:||||||||.|.|
 Frog    64 NSMNMVPDAAAKHKQLSELLRGGTTSNMSMGLG-------QQTSQNSPGINLLNSMVKSPMNQGG 121

Human   131 LTSPNMGMGTSGPNQG-------PTQSTGM---MNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQG 185
            |||||||||.|| |.|       ||.:.||   :||||||..||:|.        ||:.|||||.
 Frog   122 LTSPNMGMGGSG-NTGPTAQQINPTSAAGMIPGVNSPVNQHGMGINA--------GMMTAGNGQS 177

Human   186 IMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPL---KMGMM 247
            ::..|:||||:|:||||.|||||||.||:.||:|.|.| ||.||:|||.|:|||||.   |||:|
 Frog   178 MIQGQMMNGSVGSGRGRPNMQYPNPNMGNTGNILAETL-QGGPQIGGQPGMRGPQPTAMNKMGLM 241

Human   248 NNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQ 312
            |||||||:||.||...|:|.:.:|.|||.|..|.|:||.|.||||  ||.|||||.||.:.||||
 Frog   242 NNPNPYGTPYGQNVVPQMGGAVMGSQIQNKAALQNSLSQFPMDKK--PGVGMPNMNQQTSTQVQQ 304

Human   313 PGLVTP--------VAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHC 369
            .|:||.        ..||:||||.|||||||||||||||||||||||||||||||||||||||||
 Frog   305 TGMVTAAPPSMGAGAPQGIGSGAPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHC 369

Human   370 RTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAP 434
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||| |.:|.|.|
 Frog   370 RTMKNVLNHMTHCQAGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRN-QTLLGGPP 433

Human   435 VGLGNPSSLG-VGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQ 498
            |.||.|.::| ||||.||:::..||||||||||||||||||||.|||.||.|.|.|.||:   ||
 Frog   434 VTLGAPGAVGTVGQQPAPSINATSQIDPSSIERAYAALGLPYQGNQMQTQTQAQVKGQQS---GQ 495

Human   499 SPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPS 563
            ||||||.::.|::|.||||||||||..|||.||||||.:|:|:|||:|:..||:||.|||||.||
 Frog   496 SPQGMRSLNTMNSSTMGVNGGVGVQASSLLPDSMLHSGMNAQSPMMNESGGVPNLGSMPTAAPPS 560

Human   564 TTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAE 628
            ::||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
 Frog   561 SSGIRKPWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRAE 625

Human   629 YYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDP-S 692
            |||.|||||||||||||||||||||||:::|...||.|..||....|.|||.|:::||||||| |
 Frog   626 YYHFLAEKIYKIQKELEEKRRTRLQKQHLIPTPPGMPPTQMNQNQGMAQPQTGLSTNGPLPDPNS 690

Human   693 MIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQ 757
            |:|.:||||:|.|:..|:|:||||||.|....:..||..||||.||:.|.|.:| .||:..||||
 Frog   691 MMRANVPNQIMNRMQTQTGMNQFGQMGMQMQSMGQRQQAPLQHPGQMGQTGPMN-QMGFQARMQQ 754

Human   758 PSN-----QGQFLPQTQFPSQ------------GMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNS 805
            |..     |.|||.|.||.:.            |:|.:.:|:.....|.|.|||.|.:.|.||:|
 Frog   755 PGTMQQTAQNQFLSQNQFQASSPVMNTGGMNTGGLNASGMPMPQPGNQNPSSQAPMPNPSHPVSS 819

Human   806 PIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMP 870
            |:||||:.|:.:||....|| :|:|||||.||||||||||||.:..|       |...|..|.:|
 Frog   820 PVMPPGAAGNQMHCSSHVQP-MHRNSPSPAPSRTPTPHHTPPGLTPQ-------PTQTPVQPILP 876

Human   871 -PGPQSQA--LHPPPRQTPTPPTTQLPQQVQPSLP-------------AAPSADQPQQQ------ 913
             ..|.|||  .|   |::||||      ||.|||.             |.|.:.||.||
 Frog   877 TAAPISQAPLQH---RESPTPP------QVTPSLSIPTPVMSTADQQIATPPSQQPSQQFSSQQQ 932

Human   914 ----PRSQQSTAASVPTPTAPLLPP--QPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQP 972
                |.||.|....|.|||||.||.  ||:||   |..:::...||||||:|.||:||...::.|
 Frog   933 PLPRPPSQPSLTTPVATPTAPPLPMQLQPSTP---PTANLDCPSSNPPSTNSPEVSSQPPVQEPP 994

Human   973 SQEVKMEAKMEVD--QPE----PADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPS 1031
            .||||||.|.|.|  :||    ||:.:||..:|..||:||.|..|.||:..|:|||||||:::|:
 Frog   995 PQEVKMEIKQEDDDLEPEPMEPPAEEKPEVKAEVAVEECKSEPAELEEKKEEVKTEIKEEDEKPA 1059

Human  1032 TSATQSSPA-PGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIP-------D 1088
            |.|.|:||| |||||||||||||||||||||||||||||||||||||||||||||||       |
 Frog  1060 TPAAQTSPAPPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPKNTSVLQD 1124

Human  1089 YFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEI 1153
            ||:|||:|||||||||||||||||||||||:||||||||||||||||||||||||||:|||||||
 Frog  1125 YFEIVKTPMDLSTIKRKLDTGQYQEPWQYVEDIWLMFNNAWLYNRKTSRVYKYCSKLAEVFEQEI 1189

Human  1154 DPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQN----------RYHFCEKCFNEI 1208
            |||||||||||||||||||||||||||||||||||||||||||          ||||||||||||
 Frog  1190 DPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNSSPKYGLLADRYHFCEKCFNEI 1254

Human  1209 QGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCD 1273
            |||.|||||||:||||||:|:|||||||||||||.:|||.|||||||||||||:|.|||.||||:
 Frog  1255 QGECVSLGDDPTQPQTTISKDQFSKRKNDTLDPEQYVECLECGRKMHQICVLHNETIWPTGFVCE 1319

Human  1274 GCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPG 1338
            |||||:.|.||||||||||||:||||:||||||||||||||:||:|||.:|||||||||||||||
 Frog  1320 GCLKKTGRNRKENKFSAKRLPTTRLGSFLENRVNDFLRRQNNPEAGEVIIRVVHASDKTVEVKPG 1384

Human  1339 MKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHF 1403
            |||:|||:|||||||||||||||||||:|||:||||||||||||||||.||||||||||||||||
 Frog  1385 MKAKFVDTGEMAESFPYRTKALFAFEEVDGVELCFFGMHVQEYGSDCPQPNQRRVYISYLDSVHF 1449

Human  1404 FRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYK 1468
            ||||.||||||||||||||||||:||||.||||||||||||||||||||.|||||||||||||||
 Frog  1450 FRPKNLRTAVYHEILIGYLEYVKRLGYTAGHIWACPPSEGDDYIFHCHPADQKIPKPKRLQEWYK 1514

Human  1469 KMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENT 1533
            |||||:||||::|||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog  1515 KMLDKSVSERVIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENT 1579

Human  1534 SNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVI 1598
            ||||.:|.|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
 Frog  1580 SNESIEVGKGDSKNAKKKNNKKTSKNKSSLSRGSKKKPGMPNVSNDLSQKLYATMEKHKEVFFVI 1644

Human  1599 RLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQ 1663
            ||.||||||||||||:|||||||||||||||||||||||||||||||||:|||||||||||||||
 Frog  1645 RLSAGPAANSLPPIVEPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAKWSTMCMLVELHTQSQ 1709

Human  1664 DRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPG 1728
            ||||||||||||||||||||||||||||||||||||.|:||||||||||||||||||||||||||
 Frog  1710 DRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKTHEHKMEKLGLGLDDESNNQQAAATQSPG 1774

Human  1729 DSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHA 1793
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog  1775 DSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHA 1839

Human  1794 KHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTP 1858
            ||||||||||||||||||||||||||||||||||||||||||||.|.||.|||||||..|.|.||
 Frog  1840 KHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRAGGVGPQQGLPSPNSAGPATP 1904

Human  1859 TGQQPTTPQTPQPTSQP----QPTPPNSMPPY-LPRTQAAGPVSQGKAAGQVTPPTPPQTA--QP 1916
            |||||.|||||||..||    ||.||| |||| :.|.:.|..:||||||||:|||||||..  |.
 Frog  1905 TGQQPPTPQTPQPPPQPPTQQQPPPPN-MPPYSMARAEPARGISQGKAAGQMTPPTPPQAGAMQQ 1968

Human  1917 PLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQ--HQMPPMTPMAPMGMNPPPMTRGPSG- 1978
            .:.||||||||||||||||||||||||..|||.||:.  |||.||.||.||||||   .:||.|
 Frog  1969 QVQGPPPAAVEMAMQIQRAAETQRQMAKAQIFPRPMMNPHQMQPMNPMQPMGMNP---QQGPRGQ 2030

Human  1979 -HLEPGMGPTGMQQ------------QPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQ 2030
             |:|.|:|| ||||            ||||.|.||||.|.:|.||.|..:|||.|.|||:||.||
 Frog  2031 VHMESGIGP-GMQQPQQQQQPPPTQPQPPWVQSGLPQSQSMQPGMQRSPIMSVPQQGQPMNMNPQ 2094

Human  2031 PGLGQV-GISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYAN 2094
            .|:||| |.|..|.|::.|.|||||||||||||||:||||||:|||:|||||||||||||||||:
 Frog  2095 SGIGQVPGASQTKQGSLPQAALQNLLRTLRSPSSPMQQQQVLNILHSNPQLLAAFIKQRAAKYAS 2159

Human  2095 S-NPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPP- 2157
            | |.|.....|||| .|.||       ||.|||||.||.||||||...|.|:|||....|.|||
 Frog  2160 SQNAQAAGNVPGMP-AQAGL-------QQVVHSNPGMQGMNPMQAIGPRPGMPQQPQAPQQQPPQ 2216

Human  2158 --------MGGMSPQAQQMNMNHNTMPSQFRD-ILRRQQMM-------------QQQQQQGAGPG 2200
                    |.|::||.|.:|:|...:..|||: ||||||:|             ||||||....|
 Frog  2217 QSPLPQQAMAGINPQGQPLNINPGGISPQFREIILRRQQIMQQQQQQQQQQQQQQQQQQQQQQQG 2281

Human  2201 IGPGMANHNQFQQPQ---GVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQ 2262
            .||||.|||||||.|   |.....|||||.|||: |||||:|||:.|:||.:..:..:.||.:.|
 Frog  2282 AGPGMVNHNQFQQHQVMSGYTQQQQQQQRFQHHI-QMQQGSMGQMSQMPQGMPGDTSSGLQTFPQ 2345

Human  2263 RLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSP 2327
            |||.||||||.|.|||||||||||..||||||||||:|.||||||||||||||||||||||||||
 Frog  2346 RLLHQQMGSPAQQNPMSPQQHMLPGPAQSPHLQGQQLPPSLSNQVRSPQPVPSPRPQSQPPHSSP 2410

Human  2328 SPRMQPQPSPHHVSPQTSSPHPGLVA-AQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASAT 2391
            |||||||||||||||||||||||||. .|.|||:|||:.|||..:||||      ||.|||....
 Frog  2411 SPRMQPQPSPHHVSPQTSSPHPGLVGPGQGNPMDQGHYGSPDPTAMLSQ------MAGLHGGGVQ 2469

Human  2392 DLGLSTDNSDLNSNLSQSTLDIH 2414
            ||||..||||||.||||||||||
 Frog  2470 DLGLGADNSDLNPNLSQSTLDIH 2492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EP300	NP_001420.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		19/27 (70%)
		Interaction with RORA. /evidence=ECO:0000269|PubMed:9862959	2..149		99/153 (65%)
		Interaction with ALX1. /evidence=ECO:0000269|PubMed:12929931	2..139		92/136 (68%)
		Nuclear localization signal. /evidence=ECO:0000255	11..17		4/5 (80%)
		Med15	88..>318	CDD:312941	137/242 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..157		16/33 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235		26/38 (68%)
		zf-TAZ	347..414	CDD:460457	65/66 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..518		20/35 (57%)
		KIX	566..646	CDD:366953	76/79 (96%)
		Med15	<648..>854	CDD:312941	111/223 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	729..1050		167/372 (45%)
		CRD1, mediates transcriptional repression	1017..1029		8/11 (73%)
		Bromo_cbp_like	1051..1158	CDD:99927	102/113 (90%)
		RING_CBP-p300	1170..1242	CDD:276805	67/81 (83%)
		PHD_p300	1243..1277	CDD:277116	26/33 (79%)
		HAT_KAT11	1306..1612	CDD:400497	284/305 (93%)
		Interaction with histone. /evidence=ECO:0000269|PubMed:18273021	1397..1399		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1520..1578		53/57 (93%)
		Binding region for E1A adenovirus	1572..1818		240/245 (98%)
		ZZ_CBP	1668..1708	CDD:239077	37/39 (95%)
		zf-TAZ	1735..1803	CDD:460457	67/67 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1833..1924		63/97 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1980..2010		19/41 (46%)
		Med15	1984..>2408	CDD:312941	288/464 (62%)
		Creb_binding	1992..2098	CDD:462659	77/107 (72%)
		Interaction with HTLV-1 Tax	2003..2212		132/233 (57%)
		Interaction with NCOA2. /evidence=ECO:0000269|PubMed:15731352	2041..2240		128/225 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2094..2163		36/78 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2186..2237		34/66 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2267..2385		96/118 (81%)
ep300	XP_004913855.2	zf-TAZ	347..414	CDD:460457	65/66 (98%)
		KIX	563..643	CDD:366953	76/79 (96%)
		DUF4175	<665..809	CDD:463981	64/144 (44%)
		Atrophin-1	761..>982	CDD:460830	97/240 (40%)
		Bromo_cbp_like	1080..1194	CDD:99927	102/113 (90%)
		RING_CBP-p300	1206..1288	CDD:276805	67/81 (83%)
		PHD_p300	1289..1323	CDD:277116	26/33 (79%)
		HAT_KAT11	1352..1658	CDD:400497	284/305 (93%)
		ZZ_CBP	1714..1754	CDD:239077	37/39 (95%)
		zf-TAZ	1781..1849	CDD:460457	67/67 (100%)
		Med15	1877..>2190	CDD:312941	209/325 (64%)
		Creb_binding	2061..2161	CDD:462659	71/99 (72%)
		PAT1	<2324..>2463	CDD:401645	106/144 (74%)