Protein Alignment EP300 and ep300b

DIOPT Version :10

• Sequence 1: NP_001420.2
• Gene: EP300 / 2033
• HGNCID: 3373
• Length: 2414
• Species: Homo sapiens
• Sequence 2: XP_009297682.1
• Gene: ep300b / 565612
• ZFINID: ZDB-GENE-080403-15
• Length: 2646
• Species: Danio rerio
• Alignment Length: 2797
• Identity: 1566/2797 - (55%)
• Similarity: 1768/2797 - (63%)
• Gaps: 544/2797 - (19%)

Human     1 MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQ 65
            ||:||::.|||:||||||||||||.|||||.|||||||||||||||||||::|||.||.|.:||.
Zfish     1 MADNVLDSGPPTAKRPKLSSPALSVSASDGNDFGSLFDLEHDLPDELINSSDLGLPNGMDPSQLH 65

Human    66 TSLG----------MVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINS 120
            ||||          ..||.|:|||.||||||.|:.|:.:...|.||         ::..||::..
Zfish    66 TSLGGGGMSGPLGVSGQDTAAKHKHLSELLRPGAPPSASTATGSPG---------NAASLGMMGG 121

Human   121 MVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAA--GNG 183
            :...|:||        |||      ||.|...||..|          ||..|:|..|:..  |||
Zfish   122 LSGGPVTQ--------GMG------GPQQQPSMMPQP----------GMVGGLNRAMMGTQKGNG 162

Human   184 --QGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQ-GSPQMGGQTGLRGPQP---L 242
              |.:|..|:|||:...|....||   |.||...||:|.:.||| .:.|...|..:|..||   .
Zfish   163 QPQSMMGGQMMNGAPRMGYANVNM---NAGMAGNGNMLPDSLQQPNAGQQMAQAAMRPQQPGAVN 224

Human   243 KMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPA 307
            |||||..|.|||..|    ||..|.|.||.|:|.|....|:::.|.||||       |.:||...
Zfish   225 KMGMMGAPGPYGGSY----GQCGGQSQLGPQLQNKAGQPNSINQFNMDKK-------PQLGQNMG 278

Human   308 PQVQQPGLVTPVAQGMGSGA-HTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRT 371
             .:|.||:|..|:...|:.| ..||||||||||||||||||||||.|||||||||||||||||||
Zfish   279 -GMQGPGVVGGVSGPGGTAAPPAADPEKRKLIQQQLVLLLHAHKCHRREQANGEVRQCNLPHCRT 342

Human   372 MKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVG 436
            ||||||||||||:||||||||||||||||||||||||||||||||||:||||||||.:|.||.:.
Zfish   343 MKNVLNHMTHCQAGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKSAGDKRNQQSLLGGAGMA 407

Human   437 LGNP--SSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQS 499
            :|.|  .||..||.||||::..|||||||||||||||||.||.||...|      |||...|||
Zfish   408 MGGPLGGSLPGGQPSAPNINPPSQIDPSSIERAYAALGLTYQGNQASNQ------NQQTSVPGQ- 465

Human   500 PQGMRPMSNMS-ASPMGVNGGVGV----QTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTA 559
             .|||.::||: .:.||||||||.    |.|.:|.|.|||..:.:|: :|::::.|.::|...||
Zfish   466 -PGMRSLNNMAGGNSMGVNGGVGAPMSNQHPGMLPDGMLHRNMTAQS-LMNDSSGVGNMGSAATA 528

Human   560 AQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESAN 624
            ..|| .|:||.||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   529 TPPS-AGMRKSWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESAN 592

Human   625 NRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLP 689
            :||||||||||||||||||||||||||||||                             :||..
Zfish   593 SRAEYYHLLAEKIYKIQKELEEKRRTRLQKQ-----------------------------DGPHS 628

Human   690 DPSMIRGSVPNQMMPRI-----TPQS--GLNQFGQMSMAQPPIVPRQTPPL-----------QHH 736
            |||:::.:.|:||:.|:     .|.|  |:|||||:.| |.|:..|.||||           |..
Zfish   629 DPSLVQATGPSQMVNRMQNPAGMPHSLNGMNQFGQVGM-QQPMGQRATPPLPMGANLNQMSMQGT 692

Human   737 GQLAQPGALNPP-----------------MGYGP-RMQQPSNQGQFLPQTQFPSQGMNVTNIPLA 783
            .::|||   |.|                 :|.|. .:.||:.||. :||.|.|:......:.|:|
Zfish   693 PRMAQP---NVPQLQNQYMQNQFTGTGAGLGQGAVGLNQPAGQGA-MPQNQMPTPPSLSVHSPVA 753

Human   784 PSSGQAPVSQAQMSSSSCPVNSPIMPPGSQ-GSHIHCPQLPQPALHQNSPSPVPSRTPT--PHHT 845
            .|....|||.|.......|.|.|  ||..| |.|.||     |.|.||||||..|.|||  ||.|
Zfish   754 QSQSSVPVSGAAAGPQGPPSNHP--PPAPQPGLHTHC-----PPLRQNSPSPARSLTPTPAPHQT 811

Human   846 PPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQP 910
            ||.:...|.|             .|..|.|..       |..||.:|||...|.  .|:..:.|.
Zfish   812 PPQLPGNQTP-------------QPHTPNSST-------TMAPPASQLPPMAQG--VASEKSSQL 854

Human   911 QQQPRS-------QQSTAASVPTPTAPLLPPQPATPLSQ-PAVSIEGQVSNPPSTSSTEVNSQAI 967
            |||...       |...|:|||:..|..|...|.:|||| .:.:::||.|.|.|.||.:.:|| :
Zfish   855 QQQSHGGGATGGPQTGLASSVPSQNAHGLCTHPHSPLSQKSSATVDGQASTPASVSSADPSSQ-L 918

Human   968 AEKQPSQEVKMEAKMEV---DQPEPADTQPEDISESKV----------------------EDCKM 1007
            ...:|:  ..:::|.||   |:.|..:.:.||.:..|:                      ::||.
Zfish   919 TSSEPT--APLDSKTEVKQQDEEEENENETEDKASGKMAAMQTEIKSEEKPEIKKEEPAGDECKT 981

Human  1008 ESTET---EERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQD 1069
            |..||   |::..|:|||.||||    .:...|:||..|||||.|||:|||||||||||||||||
Zfish   982 EPMETSTAEDKKPEVKTEPKEEE----VAGANSTPANTQSKKKEFKPDELRQALMPTLEALYRQD 1042

Human  1070 PESLPFRQPVDPQLLGIP-----------DYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWL 1123
            ||||||||||||||||||           |||||||:|:|||||||||||||||||||||||:||
Zfish  1043 PESLPFRQPVDPQLLGIPVRIRTSNKTNLDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDDVWL 1107

Human  1124 MFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRD 1188
            ||||||||||||||||||||||:||||||||||||.|||||||||||||||||||||||||||||
Zfish  1108 MFNNAWLYNRKTSRVYKYCSKLAEVFEQEIDPVMQELGYCCGRKLEFSPQTLCCYGKQLCTIPRD 1172

Human  1189 ATYYSYQN----------RYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPEL 1243
            |.|:||||          |||||||||||||||:|||||||:||||:|||:||.::|||||||||
Zfish  1173 AAYFSYQNSSPKYGLLADRYHFCEKCFNEIQGENVSLGDDPTQPQTSINKDQFQRKKNDTLDPEL 1237

Human  1244 FVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVND 1308
            .:||.:||||||||||||:|.|||:||:||||||||..||||||::|||||.|:||.|||.||||
Zfish  1238 LLECGDCGRKMHQICVLHNETIWPSGFICDGCLKKSNSTRKENKYAAKRLPQTKLGNFLETRVND 1302

Human  1309 FLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCF 1373
            :|:|||||||||||:||||.|||.||||||||:||||||||:||||||||||||||||||.|:||
Zfish  1303 YLKRQNHPESGEVTIRVVHISDKVVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGTDVCF 1367

Human  1374 FGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWAC 1438
            |||||||||||||||||||||||||||||||:|:.|||.|||||||||||||||:|:..||||||
Zfish  1368 FGMHVQEYGSDCPPPNQRRVYISYLDSVHFFQPRHLRTGVYHEILIGYLEYVKKMGFVMGHIWAC 1432

Human  1439 PPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPY 1503
            ||||||||||||||.||||||||||||||||||||||:|||||||||||||||||||||||||||
Zfish  1433 PPSEGDDYIFHCHPSDQKIPKPKRLQEWYKKMLDKAVTERIVHDYKDIFKQATEDRLTSAKELPY 1497

Human  1504 FEGDFWPNVLEESIKELEQEEEERKREE-NTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGN 1567
            |||||||||||||||||||||||||||| |||:||.|.|.|||||||||||||||||||||||.|
Zfish  1498 FEGDFWPNVLEESIKELEQEEEERKREENNTSSESIDATNGDSKNAKKKNNKKTSKNKSSLSRAN 1562

Human  1568 KKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLT 1632
            ||||||||||||||||||||||||||||||||.||||||||||||.|||.|:.||||||||||||
Zfish  1563 KKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRFIAGPAANSLPPISDPDTLMACDLMDGRDAFLT 1627

Human  1633 LARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYN 1697
            |||||||||||||||:||:||||||||.|:||||||||||||||||||:||||||||||||||||
Zfish  1628 LARDKHLEFSSLRRAKWSSMCMLVELHNQTQDRFVYTCNECKHHVETRFHCTVCEDYDLCITCYN 1692

Human  1698 TKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMK 1762
            .|.|:|||||||||||||||||.||:||:||||||||||||||||||||||||||||||||||||
Zfish  1693 VKGHEHKMEKLGLGLDDESNNQAAASTQNPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMK 1757

Human  1763 RVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQM 1827
            ||||||||||||||||||||||||||||||||||||.|||||||||||.||||||||||||||||
Zfish  1758 RVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQETKCPVPFCLNIKHKLRQQQLQHRLQQAQM 1822

Human  1828 LRRRMASMQRTGVV-----GQQQGLPSP------TPATPTTPTGQQPTTPQTPQ----------- 1870
            ||||||:|||.|..     |...|||||      .|:|||: .|.||.|||||.
Zfish  1823 LRRRMATMQRVGQPPPCGGGPPGGLPSPGNNGATGPSTPTS-VGTQPATPQTPTQLTPNLISLPQ 1886

Human  1871 ------PTSQPQPTPP-----------------NSMPPYLPRTQAAGPV---------------- 1896
                  |...||.:|.                 ||....:...|:.|.|
Zfish  1887 PGAGGVPAGAPQQSPQHPVHHQFQQMPGAGGMMNSQQQQMVPQQSLGQVPHPHNQYGPHPTGPSP 1951

Human  1897 ---SQGK-AAGQVTPP-------TPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQR 1950
               |||| ..|..|||       |.|...|....|||.||||:||:||:.|:.||:||.||:.||
Zfish  1952 NTQSQGKPGLGPATPPQLPSNPGTVPMAQQQQPTGPPAAAVEIAMKIQQVADAQRKMAQVQLLQR 2016

Human  1951 --------PIQHQMPP---------MTPMAPMGMNPPPMTRGPSGHLEPGMGPTG------MQQQ 1992
                    |..||.|.         :..:.|.|:.....|......:|...||.|      ||||
Zfish  2017 QAAQAGMMPQHHQQPQGQIGVAHPGIGMVGPQGLASQAQTSANRVQMEQQQGPQGMMGAGPMQQQ 2081

Human  1993 PPWS---QGGLP--------------QPQQLQ---SGMP---RPAMMSVAQHGQPLNMAPQP--- 2031
            .|..   ||.:|              ||||.|   .|||   ||||||  |.|. ::|.|||
Zfish  2082 QPQQVAVQGQMPPQMHPQQPRMNPPLQPQQQQWPGQGMPTQQRPAMMS--QQGM-VSMQPQPQPQ 2143

Human  2032 ---------------------GLGQVGISPLKPGTVS--------QQALQNLLRTLRSPSSPLQQ 2067
                                 .:.|.|   |:.|..|        |.|||.|||||||||||.||
Zfish  2144 QPSQQTQQQQAPQMPNRNALMSMVQAG---LQSGVASGAAASNLPQGALQQLLRTLRSPSSPQQQ 2205

Human  2068 QQVLSILHANPQLLAAFIKQRAAKYAN-----SNPQPIPGQPGMPQGQP-----GLQPPTMPGQQ 2122
            ||||:||.::|.|:|||||||..||..     |.||   |.||...|||     |:..|.|...|
Zfish  2206 QQVLNILRSSPLLMAAFIKQRVHKYKGGTGGPSGPQ---GGPGPMGGQPVGVNTGVPQPGMHLGQ 2267

Human  2123 GVH--SNPAMQNMNPMQAGVQRAGL----------PQQQPQQQLQPPMGGMSPQAQQMNMNHNTM 2175
            ||:  |....|..:..|..:|:..|          .|||.|||.|........|.||....|...
Zfish  2268 GVNMQSQLLSQQQSQQQQQMQQRPLLQQQQVAALQQQQQQQQQQQQQQQQQQHQQQQQQQQHQQQ 2332

Human  2176 PSQ----------------FRD-ILRRQQMMQ-QQQQQGAGPGIGPGMANHNQFQQPQGV----- 2217
            ..|                ||: ::||||.:| |||||.........|:||..|||.||.
Zfish  2333 QQQQQGIQGQGTPNMANPHFRELVMRRQQQLQFQQQQQQQQQQQQQQMSNHAAFQQQQGYMSQQG 2397

Human  2218 -----------------------GYPPQQ------QQRM---QHHMQQMQQGN-------MG--- 2240
                                   |.|.||      |||:   ||.:|..||.|       ||
Zfish  2398 NMQVPPGGQPLQGVQPGQQQNFPGNPAQQQAAAALQQRLAQQQHQLQMQQQQNAATQGPDMGPGG 2462

Human  2241 -----QIG---QLPQALGAEAGASLQAYQQRLLQQQM----GSPVQP-NPMSPQQHMLPNQAQSP 2292
                 |:|   |.||||      ..||..|||..||.    .||.|. |||||||..:   :|||
Zfish  2463 GPQPTQLGPGLQSPQAL------LQQALHQRLFPQQQHLSGTSPAQQNNPMSPQQQQI---SQSP 2518

Human  2293 HLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSP--QTSSPHP------ 2349
            ||||||:|:||||||.|||  |||||||||||||||||:||||||||:||  ||.||||
Zfish  2519 HLQGQQLPSSLSNQVCSPQ--PSPRPQSQPPHSSPSPRLQPQPSPHHISPQTQTGSPHPSHLQQH 2581

Human  2350 --GLV-------AAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSN 2405
              |:.       ..|.|..:...|.: |||:|||||:   |||.|||..|.|: |.....||..|
Zfish  2582 HSGMAPPPPPHQQPQHNSKDPSGFGA-DQNAMLSQLS---GMAGLHGPGANDM-LPPSGQDLGIN 2641

Human  2406 LS 2407
            ::
Zfish  2642 MN 2643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EP300	NP_001420.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		21/27 (78%)
		Interaction with RORA. /evidence=ECO:0000269|PubMed:9862959	2..149		81/156 (52%)
		Interaction with ALX1. /evidence=ECO:0000269|PubMed:12929931	2..139		77/146 (53%)
		Nuclear localization signal. /evidence=ECO:0000255	11..17		4/5 (80%)
		Med15	88..>318	CDD:312941	82/237 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..157		8/23 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235		14/39 (36%)
		zf-TAZ	347..414	CDD:460457	64/66 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..518		15/36 (42%)
		KIX	566..646	CDD:366953	76/79 (96%)
		Med15	<648..>854	CDD:312941	83/244 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	729..1050		123/388 (32%)
		CRD1, mediates transcriptional repression	1017..1029		8/11 (73%)
		Bromo_cbp_like	1051..1158	CDD:99927	101/117 (86%)
		RING_CBP-p300	1170..1242	CDD:276805	62/81 (77%)
		PHD_p300	1243..1277	CDD:277116	25/33 (76%)
		HAT_KAT11	1306..1612	CDD:400497	280/306 (92%)
		Interaction with histone. /evidence=ECO:0000269|PubMed:18273021	1397..1399		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1520..1578		52/58 (90%)
		Binding region for E1A adenovirus	1572..1818		227/245 (93%)
		ZZ_CBP	1668..1708	CDD:239077	35/39 (90%)
		zf-TAZ	1735..1803	CDD:460457	66/67 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1833..1924		46/162 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1980..2010		17/55 (31%)
		Med15	1984..>2408	CDD:312941	237/602 (39%)
		Creb_binding	1992..2098	CDD:462659	65/165 (39%)
		Interaction with HTLV-1 Tax	2003..2212		105/286 (37%)
		Interaction with NCOA2. /evidence=ECO:0000269|PubMed:15731352	2041..2240		102/290 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2094..2163		27/90 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2186..2237		27/88 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2267..2385		79/139 (57%)
ep300b	XP_009297682.1	Med15	126..>276	CDD:312941	70/187 (37%)
		zf-TAZ	318..385	CDD:460457	64/66 (97%)
		KIX	534..614	CDD:366953	76/79 (96%)
		PABP-1234	<659..760	CDD:130689	32/105 (30%)
		PHA03247	<729..932	CDD:223021	81/235 (34%)
		Bromo_cbp_like	1024..1142	CDD:99927	101/117 (86%)
		RING_CBP-p300	1154..1236	CDD:276805	62/81 (77%)
		PHD_SF	1237..1271	CDD:473978	25/33 (76%)
		HAT_KAT11	1300..1608	CDD:400497	281/307 (92%)
		ZZ_CBP	1663..1703	CDD:239077	35/39 (90%)
		zf-TAZ	1730..1798	CDD:460457	66/67 (99%)
		PAT1	<1870..>2020	CDD:401645	45/149 (30%)
		PAT1	<1954..>2100	CDD:401645	50/145 (34%)
		Creb_binding	<2168..2231	CDD:462659	38/65 (58%)