|
Human 1 MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTE---------LGLT 56
||:::.| |..||.|: |.||.. :.||.:|||||::|.. .|..
Fly 2 MADHLDE---PPQKRVKM----------DPTDIS--YFLEENLPDELVSSNSGWSDQLTGGAGGG 51
Human 57 NGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPN-----------------LNMGVGG----- 99
|||. .:.|:..:..|.. ..|..|| :|:||||
Fly 52 NGGG-----GASGVTTNPTSGP-------NPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVG 104
Human 100 --PGQV-------------------------------------MASQAQQSSPGLGLINSMVKSP 125
|.|: :..|.||...| :||...
Fly 105 VVPSQMNGAGGGNGSGTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKG-----AMVVPG 164
Human 126 MTQAGLTSPNMGMGTSGPNQGPTQS-TGMMNSPVNQPAMGMNTGMNAGMN--PGM--LAAGNGQG 185
|.|.|..|||: ..||||..|. .|.....||...|.::...|.||| ||| :|.||
Fly 165 MQQLGSKSPNL----QSPNQGGMQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGN--- 222
Human 186 IMPNQVMNGSIGAGRGRQ-NMQYPNPGMGSAG--NLLTEP------------------------- 222
:.|.|:..|:|.|.|.. |.....||.|..| |.::.|
Fly 223 -LGNMVLTNSVGGGMGGMVNHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMH 286
Human 223 LQQGSPQMGGQTG----LRGPQPLKM-----GMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKT 278
:|.| |.||...| ||||..:.. |..|.|.. |.|..|||..|:.......|:
Fly 287 MQNG-PMMGRMVGQQHMLRGPHLMGASGGAGGPGNGPGG-GGPRMQNPNMQMNFRPFAAQL---- 345
Human 279 VLSNNLSPFAMDKKAVPGGG-------------------------MPNM---------------- 302
|..|:.:.:...|||| :|.|
Fly 346 ----NSLPYGVGQYGGPGGGNNPQQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPVGTVVPMSTL 406
Human 303 ---GQQPAPQV----------------------------------------QQPGL--------- 315
|..||.|: ||||.
Fly 407 GGDGSGPAGQLVSGNPQQQQMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQG 471
Human 316 -----------------VTPVAQGMGSGA-HTADP---------EKRKLIQQQLVLLLHAHKCQR 353
|..||.|...|| .::.| ::::.|||||:||||||||.|
Fly 472 VGIGGAGVVANAGTVAGVPAVAGGGAGGAVQSSGPGGANRDVPDDRKRQIQQQLMLLLHAHKCNR 536
Human 354 REQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLK 418
||..|.....||:.:|:.||:||.||..|:..|.|.:.||||||||:.|:|.|....|.:|.|.:
Fly 537 RENLNPNREVCNVNYCKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFR 601
Human 419 -----------------------------------NAG------------DKRNQQPILTG---- 432
.|| .::||||.|||
Fly 602 QNHSVFQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVD 666
Human 433 -------APVGLGN-----PSSLGVG--------------------------------------- 446
||.|..| |...|.|
Fly 667 GKQGQQVAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRR 731
Human 447 --------------QQSAPNLSTVSQIDPSSIERAYAALG------------LPYQVN------- 478
||....|..|.:| ...:.|...|| ||..||
Fly 732 FDGMSQQVVAGGMQQQQQQGLPPVIRI--QGAQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQ 794
Human 479 QMPTQPQVQAKN-------------QQNQQPGQSPQGMRPMSNMSASPMGVN------------- 517
||..|.|.|.:| ||:||..|.|...:...|:.| |:.||
Fly 795 QMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPA-PLSVNVGGFGNTNFGGAA 858
Human 518 --GGVGVQTPSLLSDSMLH------------SAINSQNPMMSENASVPSLGPMPT-----AAQPS 563
|.||......|..:.:| :...:....::..:|| |.|..| |..|:
Fly 859 AGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSV--LMPADTTGSGNAGNPN 921
Human 564 ----------------TTG----IRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENL 608
.|| ..|.|.|.:|.|||||||||||||||||.||..::|:||.||
Fly 922 QNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNL 986
Human 609 VAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKR-RTRLQKQNMLPNAAGMV-PVSMNP 671
|:||.|||.||||.|.:|:||||||||||||||||||||| :.:.|.|.||....|:. ||:...
Fly 987 VSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGA 1051
Human 672 GPNMG----------------QPQPGMTSNGPLPDPSMIRGSV--------PNQMMPRITP---- 708
....| |.|......|..|..|.|..|: |.|:.|:..|
Fly 1052 AGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMGGVMPPQQLRPQGPPGILG 1116
Human 709 ---QSGLN------------------------------QFGQMSMAQPP---------------- 724
.:||. ||.|....|||
Fly 1117 QQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSP 1181
Human 725 --------IVPRQ-----TPPLQHHGQLAQPGALNPPMGYG--PRM----------------QQP 758
:.|.| |.|:. ||..|...:|...|.| |:: ||.
Fly 1182 GGMVVNPALSPYQTTNVLTSPVP--GQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQ 1244
Human 759 SNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPI---------------- 807
..||..|||:.|.: :.||.....|....|.|..::|...:||:
Fly 1245 QQQGMLLPQSPFSN------STPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGS 1303
Human 808 ----MP---------------PGSQGS----HIHCPQLPQPALHQNSPS-PVPS---RTPTPHHT 845
|| ||:.|| .:..|. |.|....|.|| ..|| ...:.::.
Fly 1304 VLNNMPPTPTSLEALNAGAGAPGTGGSASNVTVSAPS-PSPGFLSNGPSIGTPSNNNNNSSANNN 1367
Human 846 PPSIGA-QQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQ 909
|||:.: .|.|.:..|. |||.:|..| .|....:.|.....|:..||..|..
Fly 1368 PPSVSSLMQQPLSNRPG---TPPYIPASP-----------VPATSASGLAASSTPASAAATCASS 1418
Human 910 PQQQPRSQQSTAA------------------SVPTPTAPLLPP---------------QPATPLS 941
......|..:||| ||.|||:..:.. ...||.|
Fly 1419 GSGSNSSSGATAAGASSTSSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPAS 1483
Human 942 QPAVSIEGQV----SNPPSTSSTEVNSQAIAEKQ--PSQEVKMEAKM-----EVDQPEPADT--- 992
.|.:.:.|.. :...:|:||..:|:.::... .||...:||.. |...|...:|
Fly 1484 NPLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGS 1548
Human 993 -------------------QPEDI------------SESKVEDC------------------KME 1008
|.:|| ::|...|| |||
Fly 1549 GGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKME 1613
Human 1009 STETE---ERSTELKTEIKEEED-----------------------------------------Q 1029
.:|| :...::|||..:.:: :
Fly 1614 -IKTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIK 1677
Human 1030 PSTSATQSSPAP-----GQSKKKI-FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD 1088
|.|......|.| |..|||. |.|||||.||:||||.||||:|||:|||.|||||.|||||
Fly 1678 PKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPD 1742
Human 1089 YFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEI 1153
||:|||.||||.||:..:..|:|.:||:||||:||||:|||||||||||||:||:|||||||.||
Fly 1743 YFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEI 1807
Human 1154 DPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQ----------NRYHFCEKCFNEI 1208
|||||:||||||||..|:||.|||||||||||||||.||||| |||.:|:||||:|
Fly 1808 DPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDI 1872
Human 1209 QGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCD 1273
||::|:|||||.|.||.|.|:||.:.|||.|:.|.||.|.|||||.||||||..:.|||.|||||
Fly 1873 QGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCD 1937
Human 1274 GCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPG 1338
.||||....||||||:|||||:|:||.::|.|||:||::: ...:|||.:|||.:|||.||||||
Fly 1938 NCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKK-EAGAGEVHIRVVSSSDKCVEVKPG 2001
Human 1339 MKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHF 1403
|:.|||:.|||...||||.||||||||:||:|:||||||||||||:||.||.|||||:|||||||
Fly 2002 MRRRFVEQGEMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHF 2066
Human 1404 FRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYK 1468
|||:..|||||||||:||::|||:||||..|||||||||||||||||||.|||||||||||||||
Fly 2067 FRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYK 2131
Human 1469 KMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENT 1533
|||||.:.|||:.|||||.|||.||:|.||.|||||||||||||||||||||:|||||::::...
Fly 2132 KMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEA 2196
Human 1534 ----------SNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATM 1588
|.|..:|: ||.|...:|..||::|:|:: .|.|.||.......||||.|:||||
Fly 2197 AEAAAAANLFSIEENEVS-GDGKKKGQKKAKKSNKSKAA-QRKNSKKSNEHQSGNDLSTKIYATM 2259
Human 1589 EKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMC 1653
||||||||||||.:..:|.||.||.|||||:.||||||||||||||||||.|||||||||:||:.
Fly 2260 EKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLS 2324
Human 1654 MLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDES-- 1716
||.|||.|.||:||||||.||..||||:|||||:|:||||.|.....|.|||||||..:||.|
Fly 2325 MLYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSAL 2389
Human 1717 -NNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCP 1780
:::|| :|.::|:.|||||||||.||||||:|||.||||||||.||||||.||||.|||||
Fly 2390 ADHKQA----NPQEARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCP 2450
Human 1781 ICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQ 1845
||||||||||||||:|:|.|||||||.|||.||:|||.|.:.||.|:||||:|.|.||......|
Fly 2451 ICKQLIALCCYHAKNCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQ 2515
Human 1846 GLPSPTPAT---PTTPTGQQPTTPQTPQPTSQPQ-PTPPNSMPP----YLPRTQAA-GPVSQGKA 1901
| ||. ||..:|..|....:....||.. |.....:|| ..|.|.|. .|||.|..
Fly 2516 G-----PAAVSGPTVVSGGVPVVGMSGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAG 2575
Human 1902 AGQVTPPTPPQTAQPPL---PG----PPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPM 1959
||.:...|.|...||.: || |.|..:::..|:|..|..| |::|...|.:.:
Fly 2576 AGGMGGMTSPHPHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQ-QVSHGGGFGKGV------- 2632
Human 1960 TPMAPMGMNPPPMTRGPSGHL-------------------------------------------E 1981
||||..||.|....||:.:: .
Fly 2633 -PMAPPVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPGAPISG 2696
Human 1982 PGMGPTGMQQQPPW-----------------------SQGGLPQP--------------QQLQSG 2009
|||....:.....| :.||:.|| ||:..|
Fly 2697 PGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMGG 2761
Human 2010 MPRP-----AMMSV-AQHG--------QPL-----NMAPQPGLGQVGISPLKPGTVSQQALQNLL 2055
:..| ..|.| .||| .|: .:.|.||.|..|.|....|..:|| |..::
Fly 2762 LGGPNQLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQ-LALIM 2825
Human 2056 RTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPG----MPQGQPGLQPP 2116
:.:::..:....|.:|:||..|||::||.|||| :.:.:|.....|.|| :.|.|.|..|
Fly 2826 QKIKNNPTNESNQHILAILKQNPQIMAAIIKQR--QQSQNNAAAGGGAPGPGGALQQQQAGNGP- 2887
Human 2117 TMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRD 2181
.||..|.....|..| :.|||.|..:....||..| ||||.|......|.
Fly 2888 ---------QNPQQQQQQQQQQQV----MQQQQMQHMMNQQQGGGGP--QQMNPNQQQQQQQV-- 2935
Human 2182 ILRRQQMMQQQQQQG-AGPGIG-----------------------PGMA---------NHNQFQQ 2213
.:||||||.| .|||.| ||:: |.|:.:.
Fly 2936 -----NLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMRY 2995
Human 2214 PQGVGYPPQQQQRMQ-HHM---------QQMQQGNMGQ----------------IGQLPQALGAE 2252
.|...|||...||.: .|| ||...|..|. :|.:|...|..
Fly 2996 MQMSQYPPPYPQRQRGPHMGGAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGVPGGAGTV 3060
Human 2253 AG------ASLQAYQQRLLQQQ------MGSPVQPNPMSPQQHM--------------------- 2284
.| |:..|....|.||| :|..|:|.|...||.|
Fly 3061 PGGDQYSMANAAAASNMLQQQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQQQQPLQQQ 3125
Human 2285 ------LPN-QAQSP---------HLQGQQIPNSLSNQ----------VRSPQPVPSPRPQSQPP 2323
:|| .||:| .:.|...|:||..| :|||||.||||
Fly 3126 QMMQVAMPNANAQNPSAVVGGPNAQVMGPPTPHSLQQQLMQSARSSPPIRSPQPTPSPR------ 3184
Human 2324 HSSPSPRMQP------QPSPHHV------SPQTSSPHPGL 2351
|:||||..| ||||||| :|| ..||.|:
Fly 3185 -SAPSPRAAPSASPRAQPSPHHVMSSHSPAPQ-GPPHDGM 3222
| 
