Protein Alignment EP300 and Ep300

DIOPT Version :10

• Sequence 1: NP_001420.2
• Gene: EP300 / 2033
• HGNCID: 3373
• Length: 2414
• Species: Homo sapiens
• Sequence 2: XP_006521152.1
• Gene: Ep300 / 328572
• MGIID: 1276116
• Length: 2422
• Species: Mus musculus
• Alignment Length: 2430
• Identity: 2268/2430 - (93%)
• Similarity: 2318/2430 - (95%)
• Gaps: 24/2430 - (0%)

Human     1 MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQ 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Mouse     1 MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDISQLQ 65

Human    66 TSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAG 130
            ||||:||||||||||||||||||||||||||||||||.|||||||:||||.||||||||||.|.|
Mouse    66 TSLGIVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQAMASQAQQNSPGLSLINSMVKSPMAQTG 130

Human   131 LTSPNMGMGTSGPNQGPTQS-TGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNG 194
            |||||||:|:|||||||||| .|||||||||||||||||||||||||||||||||||||||||||
Mouse   131 LTSPNMGIGSSGPNQGPTQSPAGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNG 195

Human   195 SIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQ 259
            ||||||||.||||||.|||:||:||||||||||||||||.||||||||||||||||:||||||||
Mouse   196 SIGAGRGRPNMQYPNAGMGNAGSLLTEPLQQGSPQMGGQPGLRGPQPLKMGMMNNPSPYGSPYTQ 260

Human   260 NPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMG 324
            |.|||||||||||||||||||.|||||||||||||||||||:|||||.|.|||||||||||.|||
Mouse   261 NSGQQIGASGLGLQIQTKTVLPNNLSPFAMDKKAVPGGGMPSMGQQPTPSVQQPGLVTPVAAGMG 325

Human   325 SGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQ 389
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 SGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQ 390

Human   390 VAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLS 454
            ||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||.|:||
Mouse   391 VAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQSILTGAPVGLGNPSSLGVGQQSTPSLS 455

Human   455 TVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGG 519
            |||||||||||||||||||||||||:|.||||||||||:|..||||||||.::||||||||||||
Mouse   456 TVSQIDPSSIERAYAALGLPYQVNQIPPQPQVQAKNQQSQPSGQSPQGMRSVNNMSASPMGVNGG 520

Human   520 VGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLV 584
            ||||||:|||||||||.||||||||||||.|.||||:|||||||:||||||||||||||||||||
Mouse   521 VGVQTPNLLSDSMLHSTINSQNPMMSENAGVASLGPLPTAAQPSSTGIRKQWHEDITQDLRNHLV 585

Human   585 HKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRR 649
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 HKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRR 650

Human   650 TRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQ 714
            ||||||||||||.||.||.||.|.||||...|||:|||:||||||||||||.||||:|||.||||
Mouse   651 TRLQKQNMLPNAPGMGPVPMNTGSNMGQQPTGMTTNGPVPDPSMIRGSVPNHMMPRMTPQPGLNQ 715

Human   715 FGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTN 779
            ||||:|.||||.|||..||||||||||.|:|||||||||||||.|.|.|||.||||.||||||||
Mouse   716 FGQMNMPQPPIGPRQPSPLQHHGQLAQSGSLNPPMGYGPRMQQASGQNQFLSQTQFTSQGMNVTN 780

Human   780 IPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHH 844
            :||||||||||||||||||||||||||||||||||||||||.|||.| |||||||||||||||||
Mouse   781 MPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPTLPQQA-HQNSPSPVPSRTPTPHH 844

Human   845 TPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQ 909
            ||||||.|.||||.||.|||||||:|||||..:|||..||||||| |.||.||||||||||||||
Mouse   845 TPPSIGNQPPPATAIPTPVPTPPAIPPGPQPPSLHPSSRQTPTPP-THLPPQVQPSLPAAPSADQ 908

Human   910 PQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQ 974
            .|||||||||||.||||||||||||||:||||||||||||||||||||||||||||.|.||||||
Mouse   909 SQQQPRSQQSTAVSVPTPTAPLLPPQPSTPLSQPAVSIEGQVSNPPSTSSTEVNSQTIPEKQPSQ 973

Human   975 EVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSP 1039
            |||||:|||||:|||||.||||..|:|.||.|:|.||.|||..||||:.||||:|||||||||||
Mouse   974 EVKMESKMEVDKPEPADAQPEDTKEAKGEDVKVEPTEMEERGPELKTDGKEEEEQPSTSATQSSP 1038

Human  1040 APGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKR 1104
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1039 APGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKR 1103

Human  1105 KLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLE 1169
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1104 KLDTGQYQEPWQYIDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLE 1168

Human  1170 FSPQTLCCYGKQLCTIPRDATYYSYQN----------RYHFCEKCFNEIQGESVSLGDDPSQPQT 1224
            |||||||||||||||||||||||||||          ||||||||||||||||||||||||||||
Mouse  1169 FSPQTLCCYGKQLCTIPRDATYYSYQNSSPQYGLLADRYHFCEKCFNEIQGESVSLGDDPSQPQT 1233

Human  1225 TINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFS 1289
            |||||||||||||||||||||||||||||||||||||||||||:||||||||||:||||||||.|
Mouse  1234 TINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPSGFVCDGCLKKTARTRKENKLS 1298

Human  1290 AKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFP 1354
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1299 AKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFP 1363

Human  1355 YRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILI 1419
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1364 YRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILI 1428

Human  1420 GYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYK 1484
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1429 GYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYK 1493

Human  1485 DIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAK 1549
            ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1494 DILKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAK 1558

Human  1550 KKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVD 1614
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.||.||||||||
Mouse  1559 KKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIACPAPNSLPPIVD 1623

Human  1615 PDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVET 1679
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1624 PDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVET 1688

Human  1680 RWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVH 1744
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1689 RWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVH 1753

Human  1745 ACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNI 1809
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1754 ACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNI 1818

Human  1810 KQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQT--PQPT 1872
            |||||||||||||||||||||||||||||||.||||||||||||||||||||||.||||  ||||
Mouse  1819 KQKLRQQQLQHRLQQAQMLRRRMASMQRTGVAGQQQGLPSPTPATPTTPTGQQPATPQTPQPQPT 1883

Human  1873 SQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAE 1937
            |||||||||:|.|||||||..||||||||.|||||||||||||.|||||||||||||||||||||
Mouse  1884 SQPQPTPPNNMTPYLPRTQTTGPVSQGKAPGQVTPPTPPQTAQAPLPGPPPAAVEMAMQIQRAAE 1948

Human  1938 TQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQ 2002
            ||||||||||||||||||||.|:||||||||||||.|||.|||:||:||.||||||||:|||:||
Mouse  1949 TQRQMAHVQIFQRPIQHQMPQMSPMAPMGMNPPPMARGPGGHLDPGIGPAGMQQQPPWAQGGMPQ 2013

Human  2003 PQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQ 2067
            |||:|||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
Mouse  2014 PQQMQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGVSPLKPGTVSQQALQNLLRTLRSPSSPLQQ 2078

Human  2068 QQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQN 2132
            |||||||||||||||||||||||||||.||||:||||||.||||||||||||||||||||||:||
Mouse  2079 QQVLSILHANPQLLAAFIKQRAAKYANPNPQPLPGQPGMTQGQPGLQPPTMPGQQGVHSNPALQN 2143

Human  2133 MNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGA 2197
            |||:|||||||||||||||||||||||.||||||||||||||||||||||||||.|    |||||
Mouse  2144 MNPLQAGVQRAGLPQQQPQQQLQPPMGAMSPQAQQMNMNHNTMPSQFRDILRRQMM----QQQGA 2204

Human  2198 GPGIGPGMANHNQFQQPQGVGYPP--QQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAY 2260
            |||||||||  ||||||||:||||  ||||||||||||||||||||:||||||||||||||||||
Mouse  2205 GPGIGPGMA--NQFQQPQGIGYPPQQQQQQRMQHHMQQMQQGNMGQMGQLPQALGAEAGASLQAY 2267

Human  2261 QQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHS 2325
            ||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  2268 QQRLLQQQMGSPAQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHS 2332

Human  2326 SPSPRMQPQPSPHHVSPQTSSPHPGLVAAQ-ANPMEQGHFASPDQNSMLSQLASNPGMANLHGAS 2389
            |||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||||||
Mouse  2333 SPSPRMQPQPSPHHVSPQTSSPHPGLVAAQAANPMEQGHFASPDQNSMLSQLASNPGMANLHGAS 2397

Human  2390 ATDLGLSTDNSDLNSNLSQSTLDIH 2414
            |||||||:||:||||||||||||||
Mouse  2398 ATDLGLSSDNADLNSNLSQSTLDIH 2422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EP300	NP_001420.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		27/27 (100%)
		Interaction with RORA. /evidence=ECO:0000269|PubMed:9862959	2..149		137/146 (94%)
		Interaction with ALX1. /evidence=ECO:0000269|PubMed:12929931	2..139		129/136 (95%)
		Nuclear localization signal. /evidence=ECO:0000255	11..17		5/5 (100%)
		Med15	88..>318	CDD:312941	210/230 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..157		20/24 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235		34/38 (89%)
		zf-TAZ	347..414	CDD:460457	66/66 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..518		28/35 (80%)
		KIX	566..646	CDD:366953	79/79 (100%)
		Med15	<648..>854	CDD:312941	175/205 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	729..1050		273/320 (85%)
		CRD1, mediates transcriptional repression	1017..1029		8/11 (73%)
		Bromo_cbp_like	1051..1158	CDD:99927	105/106 (99%)
		RING_CBP-p300	1170..1242	CDD:276805	71/81 (88%)
		PHD_p300	1243..1277	CDD:277116	32/33 (97%)
		HAT_KAT11	1306..1612	CDD:400497	302/305 (99%)
		Interaction with histone. /evidence=ECO:0000269|PubMed:18273021	1397..1399		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1520..1578		57/57 (100%)
		Binding region for E1A adenovirus	1572..1818		243/245 (99%)
		ZZ_CBP	1668..1708	CDD:239077	39/39 (100%)
		zf-TAZ	1735..1803	CDD:460457	67/67 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1833..1924		82/92 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1980..2010		23/29 (79%)
		Med15	1984..>2408	CDD:312941	399/426 (94%)
		Creb_binding	1992..2098	CDD:462659	100/105 (95%)
		Interaction with HTLV-1 Tax	2003..2212		193/208 (93%)
		Interaction with NCOA2. /evidence=ECO:0000269|PubMed:15731352	2041..2240		184/200 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2094..2163		62/68 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2186..2237		42/52 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2267..2385		116/118 (98%)
Ep300	XP_006521152.1	Med15	98..>328	CDD:312941	208/229 (91%)
		zf-TAZ	348..415	CDD:460457	66/66 (100%)
		KIX	567..647	CDD:366953	79/79 (100%)
		Med15	663..>836	CDD:312941	144/173 (83%)
		Bromo_cbp_like	1050..1157	CDD:99927	105/106 (99%)
		RING_CBP-p300	1169..1251	CDD:276805	71/81 (88%)
		PHD_p300	1252..1286	CDD:277116	32/33 (97%)
		HAT_KAT11	1315..1621	CDD:400497	302/305 (99%)
		ZZ_CBP	1677..1717	CDD:239077	39/39 (100%)
		zf-TAZ	1744..1812	CDD:460457	67/67 (100%)
		Med15	1968..>2375	CDD:312941	382/412 (93%)
		Creb_binding	2003..2109	CDD:462659	100/105 (95%)