Protein Alignment EP300 and nbr1

DIOPT Version :10

• Sequence 1: NP_001420.2
• Gene: EP300 / 2033
• HGNCID: 3373
• Length: 2414
• Species: Homo sapiens
• Sequence 2: NP_001342955.1
• Gene: nbr1 / 2541353
• PomBaseID: SPBP35G2.11C
• Length: 397
• Species: Schizosaccharomyces pombe
• Alignment Length: 36
• Identity: 19/36 - (52%)
• Similarity: 24/36 - (66%)
• Gaps: 2/36 - (5%)

Human  1670 CNECKHH--VETRWHCTVCEDYDLCITCYNTKNHDH 1703
            |:.|..|  |..|:||.||||||||.:|.:..:|||
pombe   212 CDNCLAHPIVGPRFHCLVCEDYDLCSSCVSHVHHDH 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EP300	NP_001420.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Interaction with RORA. /evidence=ECO:0000269|PubMed:9862959	2..149
		Interaction with ALX1. /evidence=ECO:0000269|PubMed:12929931	2..139
		Nuclear localization signal. /evidence=ECO:0000255	11..17
		Med15	88..>318	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..157
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235
		zf-TAZ	347..414	CDD:460457
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..518
		KIX	566..646	CDD:366953
		Med15	<648..>854	CDD:312941
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	729..1050
		CRD1, mediates transcriptional repression	1017..1029
		Bromo_cbp_like	1051..1158	CDD:99927
		RING_CBP-p300	1170..1242	CDD:276805
		PHD_p300	1243..1277	CDD:277116
		HAT_KAT11	1306..1612	CDD:400497
		Interaction with histone. /evidence=ECO:0000269|PubMed:18273021	1397..1399
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1520..1578
		Binding region for E1A adenovirus	1572..1818		19/36 (53%)
		ZZ_CBP	1668..1708	CDD:239077	19/36 (53%)
		zf-TAZ	1735..1803	CDD:460457
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1833..1924
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1980..2010
		Med15	1984..>2408	CDD:312941
		Creb_binding	1992..2098	CDD:462659
		Interaction with HTLV-1 Tax	2003..2212
		Interaction with NCOA2. /evidence=ECO:0000269|PubMed:15731352	2041..2240
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2094..2163
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2186..2237
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2267..2385
nbr1	NP_001342955.1	ZnF_ZZ	56..>91	CDD:197633
		ZZ_NBR1_like	134..177	CDD:239080
		ZZ	210..253	CDD:412288	19/36 (53%)
		NBR1_like	275..385	CDD:271343