DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment EP300 and cbp-1

DIOPT Version :10

Sequence 1:NP_001420.2 Gene:EP300 / 2033 HGNCID:3373 Length:2414 Species:Homo sapiens
Sequence 2:NP_499160.2 Gene:cbp-1 / 176380 WormBaseID:WBGene00000366 Length:2017 Species:Caenorhabditis elegans


Alignment Length:2510 Identity:863/2510 - (34%)
Similarity:1131/2510 - (45%) Gaps:694/2510 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    10 PPSAKRPKLSSPALSASASD---GTD-FGSLFDLE------HDLPDELINSTELGLTNGGDINQL 64
            |||.|         |.:.||   |.| ..:|..||      .|...:...||..| .:||.....
 Worm     4 PPSKK---------SRADSDYDSGLDALSALESLEAFPTSSKDTDVDNNPSTSAG-GSGGPSGST 58

Human    65 QTSLGMVQDAASKHKQLSELLRSGSS----PNLNMGVGGPGQVM------ASQAQQSSP-----G 114
            ....|..|.|.|.:...:  |:.|.|    |..|||.|..|.|:      .||...:||     .
 Worm    59 PHPQGTPQPAPSNNGGFN--LQPGQSQPQQPPQNMGGGVNGSVLQELLMNPSQTSNNSPRPQAYP 121

Human   115 LGLINSMVKSPMTQAG----LTSPNMGM---------------------GTSGPNQGPTQSTGMM 154
            .|..|:..:|||...|    ::.|:||.                     |..|..||..|...||
 Worm   122 PGQQNAFNRSPMMPNGTPNMMSPPSMGRVPGPSPGGPQPPGPGQPQMRPGQPGMFQGDQQQQMMM 186

Human   155 NSPVNQ---------------------------------PAMGMNTGMNAGMNPGMLAAG----N 182
            .:...|                                 |..|...|..|.||..|..:|    .
 Worm   187 GAQGQQFPGMMHRYPYAQGGPPPGAQGMPQGYPGVSRGGPTPGQPMGRGAMMNGAMPRSGPMPTQ 251

Human   183 GQ-GIMPNQ-------------VMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQM--- 230
            |: ||.|||             :.:|..|..|.....||..||              |.|.|   
 Worm   252 GRPGIPPNQQAMMQPMMTDRQFMQHGQYGQQRPEFMQQYGRPG--------------GYPMMHQG 302

Human   231 -----GGQTGLRGPQPLKMGMMNNPNP---YGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPF 287
                 .||. :|||.  :|.||:|.:|   :|.|..| ||.|..|:....|.|.        :..
 Worm   303 MMMDSNGQP-IRGPN--QMMMMSNGHPGMSHGPPNGQ-PGPQAAAAQHAAQQQA--------AAQ 355

Human   288 AMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQ 352
            |..:.|..........|:.|...|:.|.......|....|...|||||||||||||||||||||.
 Worm   356 AQAQAAAQQQQQQQREQEAAAAAQRNGAGRATTPGSSMLATHQDPEKRKLIQQQLVLLLHAHKCS 420

Human   353 RREQANGEV---------RQCNLPHCRTMKNVLNHMTHC-----------QSGKSCQVAHCASSR 397
            :||:.|.:.         ..|.||||.|||.||.|||.|           |:.|.|.||||||||
 Worm   421 QREKENRDFAAKNQPPPHAACTLPHCSTMKEVLTHMTSCNVGRLCHSDTTQTTKKCSVAHCASSR 485

Human   398 QIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPS 462
            |||:|||||:|.|||||.|||...|          .|:           |.|.|:|:.:..::.:
 Worm   486 QIIAHWKNCSREDCPVCKPLKRIQD----------TPL-----------QFSLPDLANLIGVNGN 529

Human   463 SIERAYA----ALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQ 523
            |...|..    ..|.|.......|....:..|....|.|.:..|.||           .||    
 Worm   530 SNGSAEGDGLHQFGSPAMRTGNITNSLFEGFNGNPFQNGPNRGGPRP-----------PGG---- 579

Human   524 TPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLV 588
                                   |..:|:|.|      |......|:||..:|:|||||||.|||
 Worm   580 -----------------------NGEIPNLPP------PDMPDCTKEWHHQVTKDLRNHLVGKLV 615

Human   589 QAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQ 653
            :||||.|:..|:.|.|:::|:|||||||.:|:||||:|.|||||||||||||||||:||:.:||.
 Worm   616 KAIFPEPNQEAMNDNRLKDLIAYARKVEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLN 680

Human   654 KQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQM 718
            :     .||.....::.|...:.                        ||:.....:|.::..|. 
 Worm   681 Q-----GAAAHDQYAIPPSNELA------------------------QMLGVEGGRSDVHSEGS- 715

Human   719 SMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLA 783
            |||   :.|.|.               |.|.|..|.    ||..|.:                  
 Worm   716 SMA---VAPSQQ---------------NQPWGGAPN----SNMHQQI------------------ 740

Human   784 PSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPS 848
            |.:||.|    |:::|                                     |..|:..::.|:
 Worm   741 PPNGQVP----QVNNS-------------------------------------STFPSSGNSTPN 764

Human   849 IGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQ 913
            |||    ::|:.|.:                                             ||:.:
 Worm   765 IGA----SSTVSAML---------------------------------------------QPKTE 780

Human   914 PRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKM 978
            |...|:|.:         |..:|.|     |:...|      |:|||           |:..:..
 Worm   781 PMDDQNTDS---------LSSRPPT-----AIGFGG------SSSST-----------PAPIMNG 814

Human   979 EAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQ 1043
            ..|.|.|..|.::..|..:.::|  |...||...|:::       |.|            |.|..
 Worm   815 IVKKEEDPEESSNQAPPSVKDTK--DGVAESKPKEQQA-------KRE------------PTPPP 858

Human  1044 SKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDT 1108
            ::..:|..|:|.:.|:|..|.|.:.: ::.|||.|||.:||.||||.:|:|.||||.|:.:||..
 Worm   859 TEDTVFSQEDLIKFLLPVWEKLDKSE-DAAPFRVPVDAKLLNIPDYHEIIKRPMDLETVHKKLYA 922

Human  1109 GQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQ 1173
            ||||...|:.||||||.:||||||||.|:||||..||||:|..|:||||:|:||||.:||.|:|.
 Worm   923 GQYQNAGQFCDDIWLMLDNAWLYNRKNSKVYKYGLKLSEMFVSEMDPVMKSMGYCCAKKLAFTPL 987

Human  1174 TLCCYGKQLCTIPRDATYYSYQ-----------NRYHFCEKCFNEIQGESVSLGDDPSQPQTTIN 1227
            :|.|||..:|||.|:..|:.::           .||.:|:|||:.:..|.:||.::|:.......
 Worm   988 SLFCYGAAMCTIAREQQYWVFEQSSTQYNVTVTERYTYCQKCFDALPPEGISLSENPNDRNNMAP 1052

Human  1228 KEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKR 1292
            |..|:::||..:|.|.|..|..|.||.|:||.||.:.::|.||:|:.|.......:.:||:.|.:
 Worm  1053 KTSFTEQKNSVIDYEPFERCKYCMRKWHRICALHDKKVYPEGFICECCRTAKKYQKPDNKYLASK 1117

Human  1293 LPSTRLGTFLENRVNDFLRRQNHPESGE--VTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPY 1355
            ||..:|.||||:|||.|:::|...|:.:  |.:|.:...||..|||..||.::|:|.:..|.|||
 Worm  1118 LPHNKLSTFLEDRVNGFIKKQLQAEAHKYPVIIRTLCVQDKEAEVKAQMKQKYVESNQFPEKFPY 1182

Human  1356 RTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIG 1420
            ||||:||||.||||::||||:|||||||.||.||.|||||:||||||||:|:.|||.||||:|:|
 Worm  1183 RTKAVFAFEIIDGVEVCFFGLHVQEYGSACPAPNARRVYIAYLDSVHFFQPRELRTDVYHELLLG 1247

Human  1421 YLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKD 1485
            ||:|.|.||||..||||||||||||||||||||:||||||||||:||||||:|.|.|..|.::||
 Worm  1248 YLDYAKMLGYTMAHIWACPPSEGDDYIFHCHPPEQKIPKPKRLQDWYKKMLEKGVQEGSVVEFKD 1312

Human  1486 IFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERK-REENTSNESTDVTKGDSKNAK 1549
            |:|||.:|.||:..:||||||||||||:|:.|:|...||.:|| :|::...|..|...|...:.|
 Worm  1313 IYKQARDDNLTTPTQLPYFEGDFWPNVIEDCIREASNEEAQRKVKEDDDDGEDADGGLGGGDSGK 1377

Human  1550 KKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIA---GPAANSLPP 1611
            ||::|....|....::.||||.| ....|:::.|||:..||||||||.|||::   .||..: .|
 Worm  1378 KKSSKNKKNNLKKNAKMNKKKAG-SITGNEVADKLYSQFEKHKEVFFTIRLVSLQNEPAVLA-KP 1440

Human  1612 IVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHH 1676
            |.|||.|:..|:|||||.|||.||::|.||||||||::||:|:...||........||||:|.. 
 Worm  1441 ISDPDGLMQSDMMDGRDTFLTKAREEHWEFSSLRRAKYSTLCLAYSLHETDSKGMEYTCNKCSS- 1504

Human  1677 VETRWHCTVCEDYDLCITCYNTKNHDHKMEK----LGLGLDDESNNQQAAATQSPGDSRRLSIQR 1737
             ...|||..|:|:|||..|..|..|.|:|||    :|.|         .|...:.|.:|..||||
 Worm  1505 -PAVWHCQSCDDFDLCDGCKPTTQHPHEMEKIKSLIGGG---------EAGDSAAGGTRYESIQR 1559

Human  1738 CIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCP 1802
            ||.|||||||||:|||...||.||||||||||.||::.||.||:|||||||||||||||..:.|.
 Worm  1560 CIASLVHACQCRDANCRRMSCHKMKRVVQHTKMCKKRINGTCPVCKQLIALCCYHAKHCTRDACT 1624

Human  1803 VPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQ 1867
            ||||:||:|||.:|:...:.:...|:||||..:|      ...|..:|||:|.:..|        
 Worm  1625 VPFCMNIRQKLAEQKRSQQRRADMMMRRRMEGLQ------SHVGGAAPTPSTVSNGT-------- 1675

Human  1868 TPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQI 1932
               |::  .||||.|..|        ||..:|...|||                         |:
 Worm  1676 ---PSN--APTPPVSAGP--------GPAVKGGGVGQV-------------------------QM 1702

Human  1933 QRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQ 1997
            |     |.|.:||                                    .|.||.|| .||..|.
 Worm  1703 Q-----QHQGSHV------------------------------------GGSGPAGM-GQPMNSF 1725

Human  1998 GGLP---QPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLR 2059
            ||:|   .....|:|...|.|.......|...|...|||||.|                      
 Worm  1726 GGMPGMGLGPNAQNGPGLPGMNPQMNANQSRYMPNGPGLGQSG---------------------- 1768

Human  2060 SPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQ-PPTMPGQQG 2123
               :|.||||        |...:....||.......|||.   ||...||.|||| |...||  |
 Worm  1769 ---APGQQQQ--------PMYSSGMPMQRPGGLGGMNPQQ---QPQQQQGHPGLQNPGGRPG--G 1817

Human  2124 VH---SNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGG-MSPQAQQMNMNHNTMPSQ------ 2178
            ||   .|..::|...|...:      |.|.|.|..||... :.||..::|.......::      
 Worm  1818 VHGMGQNQPVRNNQDMVMNM------QMQNQHQQPPPFDSTLQPQIMKINSRLKAAKTEEERETV 1876

Human  2179 FRDI------------LRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHM 2231
            |.|:            :|..|.:...:.||... :..|.:|....||.|               :
 Worm  1877 FSDLKKTPHLFHAWLRMRENQNLVPNRMQGYSQ-MSMGSSNLQNLQQQQ---------------L 1925

Human  2232 QQMQQGNM--------GQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPV--QPNPMSPQQHMLP 2286
            ||.|.|.|        ||....|:|...:..:...:.||:..|||.|.|.  |.||...||:   
 Worm  1926 QQQQAGAMRGGGGFAPGQNNSQPRAPSGQFASMNPSMQQQYPQQQQGWPQQRQQNPGGMQQN--- 1987

Human  2287 NQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSS 2326
               .:|:.|.|...|.:.            .||.|.||.|
 Worm  1988 ---ANPYNQFQNRQNMMM------------MPQQQQPHPS 2012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EP300NP_001420.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29 5/18 (28%)
Interaction with RORA. /evidence=ECO:0000269|PubMed:9862959 2..149 49/188 (26%)
Interaction with ALX1. /evidence=ECO:0000269|PubMed:12929931 2..139 45/178 (25%)
Nuclear localization signal. /evidence=ECO:0000255 11..17 3/5 (60%)
Med15 88..>318 CDD:312941 79/331 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 133..157 10/44 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..235 11/46 (24%)
zf-TAZ 347..414 CDD:460457 45/86 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 482..518 7/35 (20%)
KIX 566..646 CDD:366953 53/79 (67%)
Med15 <648..>854 CDD:312941 33/205 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 729..1050 51/320 (16%)
CRD1, mediates transcriptional repression 1017..1029 2/11 (18%)
Bromo_cbp_like 1051..1158 CDD:99927 60/106 (57%)
RING_CBP-p300 1170..1242 CDD:276805 26/82 (32%)
PHD_p300 1243..1277 CDD:277116 15/33 (45%)
HAT_KAT11 1306..1612 CDD:400497 177/311 (57%)
Interaction with histone. /evidence=ECO:0000269|PubMed:18273021 1397..1399 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1520..1578 18/58 (31%)
Binding region for E1A adenovirus 1572..1818 136/252 (54%)
ZZ_CBP 1668..1708 CDD:239077 20/43 (47%)
zf-TAZ 1735..1803 CDD:460457 51/67 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1833..1924 20/90 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1980..2010 12/32 (38%)
Med15 1984..>2408 CDD:312941 101/379 (27%)
Creb_binding 1992..2098 CDD:462659 27/108 (25%)
Interaction with HTLV-1 Tax 2003..2212 57/231 (25%)
Interaction with NCOA2. /evidence=ECO:0000269|PubMed:15731352 2041..2240 53/229 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2094..2163 26/73 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2186..2237 11/50 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2267..2385 19/62 (31%)
cbp-1NP_499160.2 Med15 <193..>338 CDD:312941 37/162 (23%)
zf-TAZ 415..502 CDD:460457 45/86 (52%)
KIX 593..673 CDD:366953 53/79 (67%)
Bromo_cbp_like 866..972 CDD:99927 60/106 (57%)
RING_CBP-p300 970..1009 CDD:399179 20/38 (53%)
PHD_CBP_p300 1069..1100 CDD:277032 14/30 (47%)
HAT_KAT11 1131..>1346 CDD:413203 141/214 (66%)
ZZ_CBP 1497..1535 CDD:239077 19/39 (49%)
ZnF_TAZ 1551..1629 CDD:214717 56/77 (73%)
Med15 1629..>2015 CDD:312941 139/556 (25%)

Return to query results.
Submit another query.