Protein Alignment EP300 and Ep300

DIOPT Version :10

• Sequence 1: NP_001420.2
• Gene: EP300 / 2033
• HGNCID: 3373
• Length: 2414
• Species: Homo sapiens
• Sequence 2: XP_038936215.1
• Gene: Ep300 / 170915
• RGDID: 620036
• Length: 2413
• Species: Rattus norvegicus
• Alignment Length: 2423
• Identity: 2272/2423 - (93%)
• Similarity: 2319/2423 - (95%)
• Gaps: 19/2423 - (0%)

Human     1 MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQ 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
  Rat     1 MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDISQLQ 65

Human    66 TSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAG 130
            ||||:||||||||||||||||||||||||||||||||||||||||:||||.||||||||||.|.|
  Rat    66 TSLGIVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQNSPGLSLINSMVKSPMAQTG 130

Human   131 LTSPNMGMGTSGPNQGPTQST-GMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNG 194
            |||||||||:||||||||||| |||||||||||||||||||||||||||||||||||||||||||
  Rat   131 LTSPNMGMGSSGPNQGPTQSTAGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNG 195

Human   195 SIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQ 259
            ||||||||.||||||.|||:||:||||||||||||||||.||||||..|||||:||.||||||||
  Rat   196 SIGAGRGRPNMQYPNAGMGNAGSLLTEPLQQGSPQMGGQPGLRGPQSHKMGMMSNPTPYGSPYTQ 260

Human   260 NPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMG 324
            |.|||||||||||||||||||.|||||||||||||.|||||||||||.|.|||||||.|||.|||
  Rat   261 NSGQQIGASGLGLQIQTKTVLPNNLSPFAMDKKAVTGGGMPNMGQQPTPSVQQPGLVNPVAPGMG 325

Human   325 SGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQ 389
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 SGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQ 390

Human   390 VAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLS 454
            ||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||.|:||
  Rat   391 VAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQSILTGAPVGLGNPSSLGVGQQSTPSLS 455

Human   455 TVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGG 519
            |||||||||||||||||||||||||:|.||.|||||||:|..||||||||.|:||||||||||||
  Rat   456 TVSQIDPSSIERAYAALGLPYQVNQIPPQPPVQAKNQQSQPSGQSPQGMRSMNNMSASPMGVNGG 520

Human   520 VGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLV 584
            ||||||:|||||||||.||||||||:|||||.||||:|||||||:||||||||||||||||||||
  Rat   521 VGVQTPNLLSDSMLHSTINSQNPMMNENASVASLGPLPTAAQPSSTGIRKQWHEDITQDLRNHLV 585

Human   585 HKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRR 649
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 HKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRR 650

Human   650 TRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQ 714
            ||||||||||:|.|||||.||..|||||...|||:|||||||||||||||||||||:|||.||||
  Rat   651 TRLQKQNMLPSAPGMVPVPMNTAPNMGQQPTGMTTNGPLPDPSMIRGSVPNQMMPRMTPQPGLNQ 715

Human   715 FGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTN 779
            ||||::.||||.|||..||||||||||.|:|||||||||||||.|.|.|||.|||||||||||||
  Rat   716 FGQMNIPQPPIGPRQPSPLQHHGQLAQSGSLNPPMGYGPRMQQTSGQNQFLSQTQFPSQGMNVTN 780

Human   780 IPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHH 844
            :||||||.|||||||||||||||||||||||||||||||||.|||.| |||||||||||||||||
  Rat   781 MPLAPSSSQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPTLPQQA-HQNSPSPVPSRTPTPHH 844

Human   845 TPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQ 909
            ||||||.|||.||.||||||||||||||.|.|:|.||.||||||| |.||.||||||| .|.|||
  Rat   845 TPPSIGTQQPAATAIPAPVPTPPAMPPGAQPQSLRPPSRQTPTPP-THLPPQVQPSLP-VPPADQ 907

Human   910 PQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQ 974
            .|.||||||||||||||||||||||||.|||||||||:||||||||||||||||||.|.||||||
  Rat   908 SQPQPRSQQSTAASVPTPTAPLLPPQPPTPLSQPAVSVEGQVSNPPSTSSTEVNSQTIPEKQPSQ 972

Human   975 EVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSP 1039
            |||||.||:||||||||.||:|..|:|.||.|:|.||||||..|||||:|||||||||||.||||
  Rat   973 EVKMEVKMDVDQPEPADAQPDDTKEAKAEDGKVEPTETEERGPELKTEVKEEEDQPSTSAAQSSP 1037

Human  1040 APGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKR 1104
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1038 APGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKR 1102

Human  1105 KLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLE 1169
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1103 KLDTGQYQEPWQYIDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLE 1167

Human  1170 FSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKR 1234
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1168 FSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKR 1232

Human  1235 KNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLG 1299
            |||||||||||||||||||||||||||||:|||:||||||||||:||||||||||||||||||||
  Rat  1233 KNDTLDPELFVECTECGRKMHQICVLHHEVIWPSGFVCDGCLKKTARTRKENKFSAKRLPSTRLG 1297

Human  1300 TFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFE 1364
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1298 TFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFE 1362

Human  1365 EIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLG 1429
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1363 EIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLG 1427

Human  1430 YTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDR 1494
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||
  Rat  1428 YTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDILKQATEDR 1492

Human  1495 LTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKN 1559
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1493 LTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKN 1557

Human  1560 KSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLM 1624
            |||||||||||||:|||||||||||||||||||||||||||||.||.||||||||||||||||||
  Rat  1558 KSSLSRGNKKKPGVPNVSNDLSQKLYATMEKHKEVFFVIRLIACPAPNSLPPIVDPDPLIPCDLM 1622

Human  1625 DGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDY 1689
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1623 DGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDY 1687

Human  1690 DLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCS 1754
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1688 DLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCS 1752

Human  1755 LPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQ 1819
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1753 LPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQ 1817

Human  1820 HRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQT--PQPTSQPQPTPPNS 1882
            |||||||||||||||||||||.||||||||||||||||||||||.||||  |||||||||||||:
  Rat  1818 HRLQQAQMLRRRMASMQRTGVAGQQQGLPSPTPATPTTPTGQQPATPQTPQPQPTSQPQPTPPNN 1882

Human  1883 MPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQI 1947
            |.|||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1883 MTPYLPRTQTAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQI 1947

Human  1948 FQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPR 2012
            ||||||||   |.||||||||||||.|||.|||:|||||.||||||||:|||:|||||:||||||
  Rat  1948 FQRPIQHQ---MAPMAPMGMNPPPMARGPGGHLDPGMGPAGMQQQPPWAQGGMPQPQQMQSGMPR 2009

Human  2013 PAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHAN 2077
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
  Rat  2010 PAMMSVAQHGQPLNMAPQPGLGQVGVSPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHAN 2074

Human  2078 PQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQR 2142
            ||||||||||||||||||||||:|||||||||||||||||||||||||||||:||||||||||||
  Rat  2075 PQLLAAFIKQRAAKYANSNPQPLPGQPGMPQGQPGLQPPTMPGQQGVHSNPALQNMNPMQAGVQR 2139

Human  2143 AGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMAN 2207
            ||||||||||||||||||||||||||||||||||||||||||||.|    |||||||||||||||
  Rat  2140 AGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQMM----QQQGAGPGIGPGMAN 2200

Human  2208 HNQFQQPQGVGYPP-----QQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQ 2267
            |||||||||:||||     ||||||||||||||||||||:|||||||||||||||||||||||||
  Rat  2201 HNQFQQPQGIGYPPQQQQQQQQQRMQHHMQQMQQGNMGQMGQLPQALGAEAGASLQAYQQRLLQQ 2265

Human  2268 QMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQ 2332
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  2266 QMGSPAQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQ 2330

Human  2333 PQPSPHHVSPQTSSPHPGLVAAQ-ANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLS 2396
            ||||||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||
  Rat  2331 PQPSPHHVSPQTSSPHPGLVAAQAANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLS 2395

Human  2397 TDNSDLNSNLSQSTLDIH 2414
            .|::||:|||||||||||
  Rat  2396 ADSADLSSNLSQSTLDIH 2413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EP300	NP_001420.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		27/27 (100%)
		Interaction with RORA. /evidence=ECO:0000269|PubMed:9862959	2..149		139/146 (95%)
		Interaction with ALX1. /evidence=ECO:0000269|PubMed:12929931	2..139		130/136 (96%)
		Nuclear localization signal. /evidence=ECO:0000255	11..17		5/5 (100%)
		Med15	88..>318	CDD:312941	210/230 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..157		22/24 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235		34/38 (89%)
		zf-TAZ	347..414	CDD:460457	66/66 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..518		28/35 (80%)
		KIX	566..646	CDD:366953	79/79 (100%)
		Med15	<648..>854	CDD:312941	176/205 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	729..1050		272/320 (85%)
		CRD1, mediates transcriptional repression	1017..1029		9/11 (82%)
		Bromo_cbp_like	1051..1158	CDD:99927	105/106 (99%)
		RING_CBP-p300	1170..1242	CDD:276805	71/71 (100%)
		PHD_p300	1243..1277	CDD:277116	31/33 (94%)
		HAT_KAT11	1306..1612	CDD:400497	301/305 (99%)
		Interaction with histone. /evidence=ECO:0000269|PubMed:18273021	1397..1399		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1520..1578		56/57 (98%)
		Binding region for E1A adenovirus	1572..1818		242/245 (99%)
		ZZ_CBP	1668..1708	CDD:239077	39/39 (100%)
		zf-TAZ	1735..1803	CDD:460457	67/67 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1833..1924		85/92 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1980..2010		24/29 (83%)
		Med15	1984..>2408	CDD:312941	404/429 (94%)
		Creb_binding	1992..2098	CDD:462659	101/105 (96%)
		Interaction with HTLV-1 Tax	2003..2212		199/208 (96%)
		Interaction with NCOA2. /evidence=ECO:0000269|PubMed:15731352	2041..2240		190/203 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2094..2163		66/68 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2186..2237		44/55 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2267..2385		116/118 (98%)
Ep300	XP_038936215.1	Med15	88..>323	CDD:312941	213/234 (91%)
		zf-TAZ	348..415	CDD:460457	66/66 (100%)
		KIX	567..647	CDD:366953	79/79 (100%)
		PABP-1234	<647..797	CDD:130689	124/149 (83%)
		PHA03247	<659..1075	CDD:223021	355/418 (85%)
		Bromo_cbp_like	1049..1156	CDD:99927	105/106 (99%)
		RING_CBP-p300	1168..1240	CDD:276805	71/71 (100%)
		PHD_p300	1241..1275	CDD:277116	31/33 (94%)
		HAT_KAT11	1304..1610	CDD:400497	301/305 (99%)
		ZZ_CBP	1666..1706	CDD:239077	39/39 (100%)
		zf-TAZ	1733..1801	CDD:460457	67/67 (100%)
		Med15	1956..>2335	CDD:312941	358/382 (94%)
		Creb_binding	1989..2095	CDD:462659	101/105 (96%)