Protein Alignment C9orf72 and c1h9orf72

DIOPT Version :10

• Sequence 1: NP_060795.1
• Gene: C9orf72 / 203228
• HGNCID: 28337
• Length: 481
• Species: Homo sapiens
• Sequence 2: XP_012817590.1
• Gene: c1h9orf72 / 549016
• XenbaseID: XB-GENE-5871697
• Length: 461
• Species: Xenopus tropicalis
• Alignment Length: 481
• Identity: 398/481 - (82%)
• Similarity: 432/481 - (89%)
• Gaps: 20/481 - (4%)

Human     1 MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANH 65
            |:.||||||||||||.|::.|.|||||||||||||||||||||||:||::.||||||||||||||
 Frog     1 MANLCPPPSPAVAKTLISIDGYSPLLAATFAYWDNILGPRVRHIWSPKSDHVLLSDGEITFLANH 65

Human    66 TLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:||:||||||:|
 Frog    66 TLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQSELAFYLPLHKV 130

Human   131 CVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHSV 195
            ||.|||||||||||||||                    ||||..||||||||:||||||:|||.|
 Frog   131 CVARLTHIIRKGRIWMHK--------------------GQSITHMLTGEVIPIMELLSSIKSHGV 175

Human   196 PEEIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAER 260
            ||||||..|||||||||||||..||:||||||:||||||||||||||||||:||||||||:|.||
 Frog   176 PEEIDITSTVLNDDDIGDSCHGDFLINAISSHMQTCGCSVVVGSSAEKVNKMVRTLCLFLSPTER 240

Human   261 KCSRLCEAESSFKYESGLFVQGLLKDSTGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHI 325
            ||||||.:||||:|||||||||||||:||||||||||||||||||||||||:.|||||||||||.
 Frog   241 KCSRLCRSESSFQYESGLFVQGLLKDATGSFVLPFRQVMYAPYPTTHIDVDIFTVKQMPPCHEHT 305

Human   326 YNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFQLKPG 390
            ||||||||:||.|.|:|||:|::..|::|::||:|||:||||||:|||||.||.||||||||||.
 Frog   306 YNQRRYMRAELGALWKATSDEEIGMDSVIHSDETFTPNLNIFQDILHRDTFVKNFLDQVFQLKPN 370

Human   391 LSLRSTFLAQFLLVLHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKI 455
            |||||||||||||||||||||||||||||||||||||||||:||.||||.|||||.|||||||||
 Frog   371 LSLRSTFLAQFLLVLHRKALTLIKYIEDDTQKGKKPFKSLRSLKTDLDLAAEGDLYIIMALAEKI 435

Human   456 KPGLHSFIFGRPFYTSVQERDVLMTF 481
            ||||||||||..|:||:|||||||||
 Frog   436 KPGLHSFIFGSSFHTSMQERDVLMTF 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C9orf72	NP_060795.1	C9orf72-like	61..324	CDD:464450	218/262 (83%)
		Required for the homodimerization of the C9orf72-SMCR8 complex. /evidence=ECO:0000269|PubMed:32303654	461..481		15/19 (79%)
c1h9orf72	XP_012817590.1	C9orf72-like	61..304	CDD:464450	218/262 (83%)