Protein Alignment C9orf72 and zgc:100846

DIOPT Version :10

• Sequence 1: NP_060795.1
• Gene: C9orf72 / 203228
• HGNCID: 28337
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_991166.1
• Gene: zgc:100846 / 402895
• ZFINID: ZDB-GENE-040801-47
• Length: 462
• Species: Danio rerio
• Alignment Length: 482
• Identity: 351/482 - (72%)
• Similarity: 412/482 - (85%)
• Gaps: 21/482 - (4%)

Human     1 MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTE-QVLLSDGEITFLAN 64
            ||:.|||.||||||||:.:....|:|||||||||||||||||||||||:: .:||||||:|||||
Zfish     1 MSSACPPQSPAVAKTEVLVDDCCPVLAATFAYWDNILGPRVRHIWAPKSQGLLLLSDGEVTFLAN 65

Human    65 HTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHR 129
            |||||||||:|||||:|||||||:|||||||||||||...||::|..|||||||:|||||||||.
Zfish    66 HTLNGEILRSAESGAVDVKFFVLAEKGVIIVSLIFDGELKGDKNTCALSIILPQSELSFYLPLHA 130

Human   130 VCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHS 194
            |||:||.|:||||||.|.|                    |.:||.||:.|::|:||||:|||.||
Zfish   131 VCVERLKHVIRKGRICMQK--------------------GYNIISMLSSEIVPIMELLTSMKKHS 175

Human   195 VPEEIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAE 259
            ||||:|:.|||||||||||||||.||..||||||||||||:||||:.|||||||.||||||||||
Zfish   176 VPEEVDLKDTVLNDDDIGDSCHEDFLHKAISSHLQTCGCSMVVGSNPEKVNKIVLTLCLFLTPAE 240

Human   260 RKCSRLCEAESSFKYESGLFVQGLLKDSTGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEH 324
            |||||||..:.||||::||||||||||||||||.|:|||:|:||||||||||:||||||||||||
Zfish   241 RKCSRLCHPDGSFKYDTGLFVQGLLKDSTGSFVFPYRQVLYSPYPTTHIDVDINTVKQMPPCHEH 305

Human   325 IYNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFQLKP 389
            .|:||||||:||:|.|:|.||:|.:.|.:|...:|:||||||||||:|:|||||:|:|:||.|||
Zfish   306 TYHQRRYMRAELSALWKAASEDDFSSDNLINAQDSYTPDLNIFQDVMHKDTLVKSFIDEVFLLKP 370

Human   390 GLSLRSTFLAQFLLVLHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEK 454
            ||||||.:|:.|||:||||||||::||||:||||||||:||||||.|||||.|||||||||:|||
Zfish   371 GLSLRSVYLSHFLLLLHRKALTLLRYIEDETQKGKKPFRSLRNLKTDLDLTVEGDLNIIMAMAEK 435

Human   455 IKPGLHSFIFGRPFYTSVQERDVLMTF 481
            ::.|||||:||:.|.|||||||:|:.|
Zfish   436 LRAGLHSFVFGKSFLTSVQERDLLINF 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C9orf72	NP_060795.1	C9orf72-like	61..324	CDD:464450	194/262 (74%)
		Required for the homodimerization of the C9orf72-SMCR8 complex. /evidence=ECO:0000269|PubMed:32303654	461..481		13/19 (68%)
zgc:100846	NP_991166.1	C9orf72-like	62..305	CDD:464450	194/262 (74%)