Protein Alignment C9orf72 and RGD1359108

DIOPT Version :10

• Sequence 1: NP_060795.1
• Gene: C9orf72 / 203228
• HGNCID: 28337
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_001007703.1
• Gene: RGD1359108 / 313155
• RGDID: 1359108
• Length: 481
• Species: Rattus norvegicus
• Alignment Length: 481
• Identity: 470/481 - (97%)
• Similarity: 480/481 - (99%)
• Gaps: 0/481 - (0%)

Human     1 MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANH 65
            |||:|||||||||||||||||:|||||||||||||||||||||||||||:|||||||||||||||
  Rat     1 MSTICPPPSPAVAKTEIALSGESPLLAATFAYWDNILGPRVRHIWAPKTDQVLLSDGEITFLANH 65

Human    66 TLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 TLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRV 130

Human   131 CVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHSV 195
            |||||||||||||||||||||||||||:|||||||||||||||||||||||||||||:||:||||
  Rat   131 CVDRLTHIIRKGRIWMHKERQENVQKIVLEGTERMEDQGQSIIPMLTGEVIPVMELLASMRSHSV 195

Human   196 PEEIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAER 260
            ||::|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 PEDLDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAER 260

Human   261 KCSRLCEAESSFKYESGLFVQGLLKDSTGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHI 325
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
  Rat   261 KCSRLCEAESSFKYESGLFVQGLLKDATGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHI 325

Human   326 YNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFQLKPG 390
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
  Rat   326 YNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFHLKPG 390

Human   391 LSLRSTFLAQFLLVLHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKI 455
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 LSLRSTFLAQFLLILHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKI 455

Human   456 KPGLHSFIFGRPFYTSVQERDVLMTF 481
            ||||||||||||||||||||||||||
  Rat   456 KPGLHSFIFGRPFYTSVQERDVLMTF 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C9orf72	NP_060795.1	C9orf72-like	61..324	CDD:464450	256/262 (98%)
		Required for the homodimerization of the C9orf72-SMCR8 complex. /evidence=ECO:0000269|PubMed:32303654	461..481		19/19 (100%)
RGD1359108	NP_001007703.1	C9orf72-like	61..324	CDD:464450	256/262 (98%)
		Required for the homodimerization of the C9orf72-SMCR8 complex. /evidence=ECO:0000250|UniProtKB:Q96LT7	461..481		19/19 (100%)