DRSC/TRiP Functional Genomics Resources

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Protein Alignment TMEM268 and CG18507

DIOPT Version :10

Sequence 1:XP_011516652.1 Gene:TMEM268 / 203197 HGNCID:24513 Length:409 Species:Homo sapiens
Sequence 2:NP_723827.1 Gene:CG18507 / 34775 FlyBaseID:FBgn0028527 Length:514 Species:Drosophila melanogaster


Alignment Length:442 Identity:101/442 - (22%)
Similarity:160/442 - (36%) Gaps:119/442 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     9 PGATGP-LPP-----------------SSPGWSALPG----GSPPGWGQAAIENMPKY------- 44
            ||...| .||                 |:.|...:.|    .|..|:....:.:.|:.       
  Fly   111 PGEVQPHAPPPDVAPAVLTTESTHVNLSASGSGIVSGASANASASGYAPGPVRHTPQLPNQKAAA 175

Human    45 -PVLSSAWLKPGILES---------QGWNLSHPPDLLAADQWLTGPCTVVQGDLDPFVQFLYLEL 99
             |.||||    |...|         .|..:|.|.|               ||.....::.....:
  Fly   176 APSLSSA----GAASSGHQHNGGGANGTGISQPAD---------------QGSGMRTIELSTGRI 221

Human   100 QAELHNGQVLTVLRIDNT----CAPISFDLGAAEEQLQTWGIQQVPADQYRSLAESALLEPQVRR 160
            :....||.|:..|...||    ..|..|......|:|...|: .:..:.|.:..|:.:.:   .|
  Fly   222 REGFANGDVIVTLLPANTKWPWITPAIFRPELVPEELMAQGL-TLTVEDYVNAMETLVND---YR 282

Human   161 YIIYNSRPMRLAFA-VVF-YVVVWANIYSTSQ---MFALGNHWAGMLLVTLAAVSLTLTLVLVFE 220
            :.:||....|:... ::| :.|:.|.::|..|   :||||..|   |.:..||:.|.:.:.|...
  Fly   283 FTVYNICYKRILVCWILFAFTVLLALLFSGLQGVALFALGVGW---LFLNAAAIFLCMWVKLRLS 344

Human   221 RHQKKANTNTDLRLAAANGALLRHRVLLGVTDTVE-GCQSVIQLWFVYFDLENCVQFLSDHVQEM 284
            |..:|.       ||..|..|:||::||.:.|... .|..| .|.|:|||...||.||::.::..
  Fly   345 RGLEKC-------LARVNRQLMRHKILLVLDDRGRISCHKV-NLCFMYFDATQCVNFLNEFLEHT 401

Human   285 KTSQESLLRSRLSQLCVVMETGVSPATA--EGPENLEDAPLLPGNSCPNERPLMQTELHQLVPEA 347
            :                  :||.....|  |...:::...::...|.|...|..|         |
  Fly   402 E------------------QTGGDAIKAGWEAKLDIDLNDIVIQGSQPVRMPRKQ---------A 439

Human   348 EPEEMARQLLAVFGGYYIRLLVTSQLPQAMGTRHTNSPR----IPCPCQLIE 395
            ..:|:....|..:|..::|..:...:.:| |...|  ||    ..||||..|
  Fly   440 VAQELFLSYLQRWGKDFLRRRLDWTVQEA-GVHET--PRHLQSSICPCQYEE 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TMEM268XP_011516652.1 DUF4481 104..395 CDD:464322 76/306 (25%)
CG18507NP_723827.1 DUF4481 227..>400 CDD:464322 54/187 (29%)

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