Protein Alignment ADAM32 and Kul

DIOPT Version :10

• Sequence 1: NP_659441.4
• Gene: ADAM32 / 203102
• HGNCID: 15479
• Length: 787
• Species: Homo sapiens
• Sequence 2: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Alignment Length: 719
• Identity: 146/719 - (20%)
• Similarity: 257/719 - (35%)
• Gaps: 231/719 - (32%)

Human   186 LYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMF--TQF-------KVTIVLSSLELWSD 241
            |||:    .|.|.:...|||...: ..:...|..||:::  |.|       .:|.::..:::
  Fly   483 LYLQ----ADHTFFQKMGSDEASI-EAITRHVQRANTIYRNTDFNNDGKPDNITFMIKRIKV--- 539

Human   242 ENKISTVGE------ADELLQKFLEWKQSYLNLRPHD---IAYLLIYMDYPR-YLGAVFPGTM-- 294
             :.::.:.:      .:..::||||    ..:...:|   :||:..|.|:.. .||..:.|.:
  Fly   540 -HNMNAMKDPSYRFPGNYGVEKFLE----LFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKN 599

Human   295 ----C---------ITRYSAGVAL---YPKEITLEAFAVIVTQMLALSLGISYDDPKKCQ--CSE 341
                |         :...:.|:..   |.|.:......|.:...:..:.| |..||::|.  ..:
  Fly   600 AGGVCEKNGHYRGSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFG-SPHDPEQCTPGGED 663

Human   342 STCIMNPEVV---QSNGVKTFSSCSLRSFQNFISNVGVKCLQ---NKPQMQKKSPKPVCGNGRLE 400
            ...||.....   :.|..| ||:|||:|.:. :.|...:.::   .:||      ..:||||.:|
  Fly   664 GNFIMFARATSGDKKNNNK-FSTCSLKSIEP-VLNAKARSMKGCFTEPQ------SSICGNGVVE 720

Human   401 GNEICDCGTEAQCGPASCC---------DFRTCVLKDGAKC--YKGLCC-KDCQILQSGVECRPK 453
            ..|.||||.|..| ..|||         |...|.|...|:|  .:|.|| .||: |:.|.:||.
  Fly   721 PGEQCDCGWEEDC-KDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCK-LKFGDKCRD- 782

Human   454 AHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDC-------HDLDARCESVFGKGSR 511
             ...|.....|:|..|:|.|.:...|...| |.:|:||.|||       :.|:: |:.:.|
  Fly   783 -DNGCRDPSFCDGRVPQCPPSVNKPNKTIC-NKEFVCYMGDCTGSICLAYGLES-CQCIPG---- 840

Human   512 NAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRD 576
                       .|.||..:|                   .|.|..|         |:       |
  Fly   841 -----------PQDDRIKSC-------------------ELCCKLP---------GE-------D 859

Human   577 SVC-ITVDY-KLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSR 639
            |.| .:.:: :.|..||| :..|.|:.|:                           ..:|.||..
  Fly   860 SPCRSSFEWNEAPFDVPD-MYSKPGTPCN---------------------------DYNGYCDVF 896

Human   640 NKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI---VTTAIV 701
            .||.    ...|:..:.:....:..||.:.|..:    ..::.|....|.|:.:::   ::|.::
  Fly   897 QKCR----EVDPSGPLATLRKLLLSEESIASFKK----WMQHNWYTVALAAVGVILLLALSTKLL 953

Human   702 LARKQLKKW---------------------------------FAKEEEFPSSESKSEGSTQTYAS 733
            ..|..||..                                 |.|:.....::....|:..|.|:
  Fly   954 AKRSNLKLKSVTIIHSATTETVRLPENNNGVIVHTAVRTKVPFKKKVRGERTKKPGTGAGVTAAA 1018

Human   734 QSSSEGSTQTYAS-QTRSESSSQADTSKSKSEDSAEA--------------YTSRSKSQDSTQTQ 783
            ...:..:.::.|: :.:..:.|||...|...|:..:.              |::|:.:.|.....
  Fly  1019 AVGTRNAAKSSANPEPKKTTRSQAMAKKKSFEEEPKKSSKKVGKHMKEIIDYSNRNNNGDDASNL 1083

Human   784 SSSN 787
            |::|
  Fly  1084 STTN 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAM32	NP_659441.4	Pep_M12B_propep	27..144	CDD:460254
		ZnMc_adamalysin_II_like	187..381	CDD:239797	46/238 (19%)
		Disintegrin	400..474	CDD:459709	30/85 (35%)
		ACR	479..616	CDD:214743	30/145 (21%)
		SEEEED	714..786	CDD:434218	13/86 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	715..787		13/86 (15%)
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	49/251 (20%)
		Disintegrin	720..801	CDD:459709	30/84 (36%)