Protein Alignment TUBB and gammaTub37C

DIOPT Version :10

• Sequence 1: NP_001280141.1
• Gene: TUBB / 203068
• HGNCID: 20778
• Length: 464
• Species: Homo sapiens
• Sequence 2: NP_476922.1
• Gene: gammaTub37C / 35199
• FlyBaseID: FBgn0010097
• Length: 457
• Species: Drosophila melanogaster
• Alignment Length: 428
• Identity: 142/428 - (33%)
• Similarity: 242/428 - (56%)
• Gaps: 33/428 - (7%)

Human    39 KFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQ 103
            :||:.:..||||.|.|.....:....||..|::.:|....|:|||:|:||||..::::.:.|:.:
  Fly    20 EFWKRLCLEHGISPDGVLEDFATDGQDRKDVFFYQADDNHYIPRAVLIDLEPRVINNIMTSPYSK 84

Human   104 IFRPDNFVFGQ--SGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSG 166
            ::..:|....:  .|||||||.| :::|.::.:.|.|::.:||:..|.|:||.|.||:.||||||
  Fly    85 LYNQENVFLSKHGGGAGNNWASG-FSQGEKVQEEVFDILDREADGSDSLEGFVLCHSIAGGTGSG 148

Human   167 MGTLLISKIREEYPDRIMNTFSVVPS-PKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI 230
            ||:.::.::.|.:|.:::.|:||.|: .::||.||:|||:.|::.:|.:..|....:||.||..|
  Fly   149 MGSYVLERLSERFPKKLIQTYSVFPNQDEISDVVVQPYNSILTLKRLTKCADSVVVLDNTALNRI 213

Human   231 CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTS 295
            ....|.:.|||:..:|:|||..||..||.||:|..:|.:|..|..:::|.|:|||.|.|:.||.|
  Fly   214 ATERLHIQTPTFTQINNLVSTIMSLSTTTLRYPSYMNNNLIGLTASLIPTPQLHFLMTGYTPLMS 278

Human   296 --RGSQQYRALTVPELTQQVFDAKNMM-AACDPRHGR--YLTVAAVFRGRMSMKEVDEQMLNVQN 355
              ......|..||.::.:::...|||| :|...:..|  ::::..:.:|.:...:|.:.:..::.
  Fly   279 DCETKTSVRKTTVLDVMRRLLQPKNMMVSALTDKQSRQCFVSILNIIQGEVDPSQVHKSLQRIRE 343

Human   356 KNSSYFVEWIPNNVKTAVCDIPPR------------GLKMAVTFIGNSTAIQELFKRISEQFTAM 408
            :..:.|:.|.|.:::.|:    ||            ||.||     |.|.|..||||...|:..:
  Fly   344 RKLANFIPWGPASIQVAL----PRSSPYVQSAHKVSGLMMA-----NHTGISSLFKRALAQYDKL 399

Human   409 FRRKAFLHWYTGEGMDEMEFTE---AESNMNDLVSEYQ 443
            .:|.|||..:..|.|.:.:.||   |...::.||.||:
  Fly   400 RKRNAFLDNFRRESMFQDDLTELDIARDTVDCLVQEYE 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBB	NP_001280141.1	PLN00220	39..449	CDD:215107	142/428 (33%)
gammaTub37C	NP_476922.1	gamma_tubulin	4..436	CDD:276957	140/425 (33%)