DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCK5 and MCP2

DIOPT Version :9

Sequence 1:	XP_011515209.1	Gene:	ADCK5 / 203054	HGNCID:	21738	Length:	654	Species:	Homo sapiens
Sequence 2:	NP_013354.1	Gene:	MCP2 / 850955	SGDID:	S000004243	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	527	Identity:	146/527 - (27%)
Similarity:	244/527 - (46%)	Gaps:	81/527 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    99 PAVFFRRNVR---GLPPRFSSPTPLWRK--VLSTAVVGAPLLLGAR-----YVMAEAREKRRMRL 153
            |...|||.||   .:|.|    :|..||  ::...:..|.:|....     .|...|...:|:.:
Yeast    11 PFEVFRRYVRTGKSIPQR----SPRTRKSLLVGGTIASAVVLYNFNDTFHDSVKHTALTTKRIAV 71

Human   154 VVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADALVAGAISNGGL 218
            |.....|.....|..|..|.              ||.......::.||:..|...:....||||:
Yeast    72 VTQATTRCFYHYKRALNKSY--------------ENKKEREVALNKCHKMCALITLHALRSNGGI 122

Human   219 YVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQEFDYQPIAAA 283
            |:||||.:.:..:|||.|:|.|:..|:|...:..::|:||||.||......::|.||:..||..|
Yeast   123 YIKLGQHIGAMTYLLPKEWTDTMIPLQDHCPESTYEEIDELFKEDLGTSIEDMFLEFNKTPIGVA 187

Human   284 SLAQVHRAKLHD----GTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWVLQDLKG 344
            ||||||.|||.:    |:|||||.|:..|::....|:.....:..|::|..|.:..:|:..:|:.
Yeast   188 SLAQVHVAKLKNSDGKGSSVAVKCQHPSLKEFIPLDVMLTRTVFELLDVFFPDYPLTWLGDELQS 252

Human   345 TLAQELDFENEGRNAERCARELAHF---PYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQ 406
            ::..||:|..|..|||:.....:.|   ..:.:|:|  .:|.||:|..::..|.:::|:|.|.|.
Yeast   253 SIYVELNFTKEAENAEKTRHYFSKFKKQTALKIPKV--IESHKRILIMEYVGGKRLDDLEYIDSH 315

Human   407 GLAVHDIAEKLIKAFAEQIFYTGF-IHSDPHPGNVLVRKGPDGK------AELVLLDHGLYQFLE 464
            |::..:::..|...|...||.... ||.|||.||:.:|.....|      .|:||.|||||::..
Yeast   316 GISRSEVSSCLSHIFNNMIFTPNVGIHCDPHGGNLAIRSVKPAKDNGYHNFEIVLFDHGLYRYPS 380

Human   465 EKDRAALCQLWRAIIL-RDDAAMRAHA---AALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSREE 525
            .:.|....:.|.:::. :|...|:.:|   |.:..:.:.|.|..:..|.:              :
Yeast   381 TRTRRLYAKFWLSLLFDKDQTKMKKYAKGFANITDEQFPLLAAAITGRSI--------------D 431

Human   526 AAYMVDMARERFEA-----------------VMAVLRELPRPMLLVLRNINTVRAINVALGAPV- 572
            ||...|::..|.:.                 :|::|..:||.:||:|:..:..|.::..|..|:
Yeast   432 AALNYDISTSRTQEEMDVMANGILEGTLLSDLMSILSRIPRVVLLILKTNDLTRHLDECLQNPLG 496

Human   573 -DRYFLM 578
             :|.||:
Yeast   497 PERTFLI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK5	XP_011515209.1	AarF	202..>482	CDD:223733	97/294 (33%)
ADCK5	XP_011515209.1	ADCK1-like	243..483	CDD:270871	81/254 (32%)
MCP2	NP_013354.1	AarF	47..569	CDD:223733	134/487 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I2015
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I766
Isobase	1	0.950	-	0	Normalized mean entropy	S2179
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		otm53192
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.710