DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCK5 and Adck5

DIOPT Version :9

Sequence 1:	XP_011515209.1	Gene:	ADCK5 / 203054	HGNCID:	21738	Length:	654	Species:	Homo sapiens
Sequence 2:	NP_001261705.1	Gene:	Adck5 / 39260	FlyBaseID:	FBgn0036142	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	215/486 - (44%)
Similarity:	304/486 - (62%)	Gaps:	35/486 - (7%)

- Green bases have known domain annotations that are detailed below.

Human   122 RKVLS--TAVVGAPLLLGAR--YVMAEAREKRRMRLVVDGMG------------------RFGRS 164
            |::||  |.:.|...|.|.|  .|....|...|..|:..|.|                  ||.||
  Fly     8 RQLLSLGTRIRGKRALNGLREANVQKGGRPVLRFSLLAAGAGGLAYDGIVNDFTYCGASVRFVRS 72

Human   165 LKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADALVAGAISNGGLYVKLGQGLCSF 229
            ||....|:.||       || ::||.|.|...:...|:::|:.|:...:.|||||:|:|||..:.
  Fly    73 LKTAGLIAADY-------LR-LDENDPEYETKVKLLHKKSAERLLETCLLNGGLYIKVGQGFAAI 129

Human   230 NHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLH 294
            |.:||.|||.||.:|:||.|.....:|.::|.:||..||.|::|||||||:||||||||.:|:|.
  Fly   130 NDILPVEYTSTLSLLQDRCLPTTQADVQKVFRKDFGQLPEEIYQEFDYQPVAAASLAQVFKARLP 194

Human   295 DGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNA 359
            .|..|||||||.||:.||..|:.|:..|..:||.....:.|.|:|.||:..|..||:|..||:||
  Fly   195 SGEQVAVKVQYNDLQKRFISDLGTIIFLQDIVEFFFKDYNFGWILNDLRKNLVLELNFLQEGQNA 259

Human   360 ERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQ 424
            ||||:::..|.||.||:|||..:..||||.::..|||::|::.|..:.|::.||..||.:|||||
  Fly   260 ERCAKDMEKFSYVHVPKVHWSYTKTRVLTLEWMDGCKISDLKTIEKEKLSLKDIDVKLFEAFAEQ 324

Human   425 IFYTGFIHSDPHPGNVLVRKG-PDGKAELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRA 488
            ||||||:|:||||||:.|||. .:|:|:::|||||||:.|.:..|..||:.|.|.:||.:..|:|
  Fly   325 IFYTGFVHADPHPGNIFVRKNRKNGRADIILLDHGLYEELPQNVRGPLCEFWEATVLRQENRMQA 389

Human   489 HAAALGVQDYLLFAEMLMQRPVRL--GQLWGSHLLSREEAAYMVDMARERFEAVMAVLRELPRPM 551
            .|..:|:.||:.|||:|.|:|:|.  |.:.|.  |::|:..:|.::||..||.:|..|:|:||.|
  Fly   390 AAEKIGIGDYMRFAEVLFQQPIRNRGGGIRGK--LTQEDIDHMQEIARNNFEHIMGTLKEMPRSM 452

Human   552 LLVLRNINTVRAINVALGAPVDRYFLMAKRA 582
            |.|:||:||||||:...|..|:|..:||:.|
  Fly   453 LFVVRNLNTVRAISHQHGDVVNRPRVMARYA 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK5	XP_011515209.1	AarF	202..>482	CDD:223733	140/280 (50%)
ADCK5	XP_011515209.1	ADCK1-like	243..483	CDD:270871	122/240 (51%)
Adck5	NP_001261705.1	AarF	98..469	CDD:223733	180/372 (48%)
Adck5	NP_001261705.1	ADCK1-like	144..395	CDD:270871	125/250 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160016
Domainoid	1	1.000	194	1.000	Domainoid score	I3188
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34378
Inparanoid	1	1.050	387	1.000	Inparanoid score	I2029
Isobase	1	0.950	-	0	Normalized mean entropy	S2179
OMA	1	1.010	-	-		QHG56770
OrthoDB	1	1.010	-	-		D350846at33208
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		oto89971
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	1	1.100	-	-	LDO	PTHR43173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5641
SonicParanoid	1	1.000	-	-		X4477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750