DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCK5 and Adck5

DIOPT Version :9

Sequence 1:	XP_011515209.1	Gene:	ADCK5 / 203054	HGNCID:	21738	Length:	654	Species:	Homo sapiens
Sequence 2:	NP_001129270.1	Gene:	Adck5 / 362943	RGDID:	1305504	Length:	582	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	459/577 - (79%)
Similarity:	510/577 - (88%)	Gaps:	2/577 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    79 VQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPRFSSPTPLWRKVLSTAVVGAPLLLGARYVMA 143
            ::||||||.||.|||||||.||:|||||.:....|.|....|||:..|..|||.|.|.||.|.||
  Rat     5 MRLCHFHSTLLQSRQKPWPCPAIFFRRNFKSPLARTSRTRLLWRRTFSATVVGTPFLFGAHYFMA 69

Human   144 EAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADAL 208
            |:.|:|::||.|||:||||||:|:|..|||||||||||||||||||||.|:|:||||||||||||
  Rat    70 ESSERRKLRLAVDGIGRFGRSVKIGFFISLDYWWCTNVVLRGVEENSPKYVEIMSACHQRAADAL 134

Human   209 VAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQ 273
            ||||||||||||||||||||||||||.||.:|||||||:||.|||:||||||||||||||.||||
  Rat   135 VAGAISNGGLYVKLGQGLCSFNHLLPTEYIQTLRVLEDKALTRGFREVDELFLEDFQALPSELFQ 199

Human   274 EFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWV 338
            ||||:|:|||||||||||||.|||:|||||||||||||||||:|||||||||||:||||||||||
  Rat   200 EFDYEPMAAASLAQVHRAKLQDGTAVAVKVQYIDLRDRFDGDVHTLELLLRLVELMHPSFGFSWV 264

Human   339 LQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAI 403
            ||||||||||||||||||||:||||:||.||.:||:|||:||||||||||||||.||||||:|.|
  Rat   265 LQDLKGTLAQELDFENEGRNSERCAQELKHFHHVVIPRVYWDKSSKRVLTADFCDGCKVNDMEGI 329

Human   404 RSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLEEKDR 468
            :||||||.|:|.|||:.||||||:||||||||||||||||||||||||||||||||||||:||||
  Rat   330 KSQGLAVQDVATKLIQTFAEQIFHTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLDEKDR 394

Human   469 AALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAAYMVDMA 533
            ::||||||||||||||||:.||||||||||:||:|:||||||||||||||||:||||||||.|||
  Rat   395 SSLCQLWRAIILRDDAAMKTHAAALGVQDYMLFSEVLMQRPVRLGQLWGSHLISREEAAYMQDMA 459

Human   534 RERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGATYRGVY 598
            ||.|:.:|.||:.|||||||||||||||||||.:||.||||||||||.||.|||||.||.|:|:|
  Rat   460 REHFDGIMEVLKSLPRPMLLVLRNINTVRAINSSLGTPVDRYFLMAKSAVWGWSRLVGAAYQGIY 524

Human   599 GTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLSLVP--PAEELYQYLE 653
            .:.||||.||:||.|||||.||||.||||.|||:.|.:|.|...|  .|||:|||||
  Rat   525 SSRLLRHIKVIWEALKFEVILRLEILAMRFTALMLRVMVRLGFAPKAEAEEVYQYLE 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK5	XP_011515209.1	AarF	202..>482	CDD:223733	246/279 (88%)
ADCK5	XP_011515209.1	ADCK1-like	243..483	CDD:270871	209/239 (87%)
Adck5	NP_001129270.1	AarF	128..499	CDD:223733	320/370 (86%)
Adck5	NP_001129270.1	ADCK1-like	169..420	CDD:270871	218/250 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696181
Domainoid	1	1.000	450	1.000	Domainoid score	I9019
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34378
Inparanoid	1	1.050	955	1.000	Inparanoid score	I5835
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG56770
OrthoDB	1	1.010	-	-		D109470at32523
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		oto143411
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	1	1.100	-	-	LDO	PTHR43173
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4477
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410