DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCK5 and Adck5

DIOPT Version :9

Sequence 1:	XP_011515209.1	Gene:	ADCK5 / 203054	HGNCID:	21738	Length:	654	Species:	Homo sapiens
Sequence 2:	NP_766548.2	Gene:	Adck5 / 268822	MGIID:	2679274	Length:	582	Species:	Mus musculus

Alignment Length:	577	Identity:	465/577 - (80%)
Similarity:	514/577 - (89%)	Gaps:	2/577 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    79 VQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPRFSSPTPLWRKVLSTAVVGAPLLLGARYVMA 143
            ::||||||.||.|||||||.||:|||||.:..|.|.|....|||:.||..|||.|.||||.|.||
Mouse     5 MRLCHFHSTLLQSRQKPWPCPAIFFRRNFKSPPARTSRARLLWRRALSATVVGTPFLLGAYYFMA 69

Human   144 EAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQRAADAL 208
            ||.|:|::||.|||:||||||:|:||.||.||||||||||||||||||.|:|:||||||||||.|
Mouse    70 EASERRKLRLAVDGIGRFGRSVKIGLFISTDYWWCTNVVLRGVEENSPKYVEIMSACHQRAADTL 134

Human   209 VAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQALPHELFQ 273
            |||||.||||||||||||||||||||.||.:|||||||:||.|||:||||||||||||||:||||
Mouse   135 VAGAIRNGGLYVKLGQGLCSFNHLLPTEYIQTLRVLEDKALTRGFREVDELFLEDFQALPNELFQ 199

Human   274 EFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPSFGFSWV 338
            ||||:|:|||||||||||||||||.|||||||||||||||||:.||||||||||:||||||||||
Mouse   200 EFDYEPMAAASLAQVHRAKLHDGTDVAVKVQYIDLRDRFDGDVQTLELLLRLVELMHPSFGFSWV 264

Human   339 LQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKVNDVEAI 403
            ||||||||.||||||||||||||||:||.||.|||:||||||:|||||||||||.||||||:|.|
Mouse   265 LQDLKGTLVQELDFENEGRNAERCAQELKHFHYVVIPRVHWDRSSKRVLTADFCNGCKVNDMEGI 329

Human   404 RSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLEEKDR 468
            :||||||.|:|:|||:.||||||:||||||||||||||||||||||||||||||||||||:||||
Mouse   330 KSQGLAVQDVAKKLIQTFAEQIFHTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQFLDEKDR 394

Human   469 AALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAAYMVDMA 533
            ::||||||||||||:|||:.||||||||||:||:|:||||||||||||||||:||||||||.|||
Mouse   395 SSLCQLWRAIILRDNAAMKKHAAALGVQDYMLFSEVLMQRPVRLGQLWGSHLISREEAAYMQDMA 459

Human   534 RERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGATYRGVY 598
            ||.|:.:|.||:.|||||||||||||||||||..||.||||||||||.||.|||||.||.|:|:|
Mouse   460 REHFDGIMEVLKALPRPMLLVLRNINTVRAINSNLGTPVDRYFLMAKSAVWGWSRLVGAAYQGIY 524

Human   599 GTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLSLVP--PAEELYQYLE 653
            |:|||||.||:||.||||:|||||.||||||||:.|.||.|...|  .|||:|||||
Mouse   525 GSSLLRHIKVLWEALKFEMALRLEILAMRLTALMLRVLVRLGFAPKAEAEEVYQYLE 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK5	XP_011515209.1	AarF	202..>482	CDD:223733	245/279 (88%)
ADCK5	XP_011515209.1	ADCK1-like	243..483	CDD:270871	210/239 (88%)
Adck5	NP_766548.2	AarF	78..568	CDD:223733	411/489 (84%)
Adck5	NP_766548.2	ADCK1-like	169..420	CDD:270871	218/250 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83972912
Domainoid	1	1.000	452	1.000	Domainoid score	I9442
eggNOG	1	0.900	-	-		E1_COG0661
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34378
Inparanoid	1	1.050	967	1.000	Inparanoid score	I6106
Isobase	1	0.950	-	0	Normalized mean entropy	S2179
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG56770
OrthoDB	1	1.010	-	-		D155590at7742
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		oto127373
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	1	1.100	-	-	LDO	PTHR43173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5641
SonicParanoid	1	1.000	-	-		X4477
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	20	20.250