DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ADCK5 and SPAC10F6.14c

DIOPT Version :9

Sequence 1:	XP_011515209.1	Gene:	ADCK5 / 203054	HGNCID:	21738	Length:	654	Species:	Homo sapiens
Sequence 2:	NP_593265.1	Gene:	SPAC10F6.14c / 2541671	PomBaseID:	SPAC10F6.14c	Length:	535	Species:	Schizosaccharomyces pombe

Alignment Length:	393	Identity:	118/393 - (30%)
Similarity:	199/393 - (50%)	Gaps:	9/393 - (2%)

- Green bases have known domain annotations that are detailed below.

Human   197 MSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFL 261
            :.|.|||.|..|......|||||:|:||.:...::.||..|.:..:.:.|.|.:..::|:.::|.
pombe   102 IDALHQRVAQRLFKTIYKNGGLYIKMGQIIAMQSNNLPEAYGKAFQGMFDNAPQVEWEELQDIFK 166

Human   262 EDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLV 326
            |.:.....|:|...:.:..|:||:||||||.|..|..||||:|..|:..:...|:...:.::.:.
pombe   167 EQYGRPVEEVFASIEKRAAASASIAQVHRAVLPSGEKVAVKIQKPDVAKQMSWDLLVYKYMMYVY 231

Human   327 E--VMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPY----VVVPRVHWDKSSKR 385
            :  :.|....|:  :..:...|..|:||..|..|:|.....:....|    :.:|:|:.:.|.||
pombe   232 DKWIFHIPLYFT--VDYVSERLRSEVDFTTEANNSEHAREGVEETDYLRDKIYIPKVYKEISGKR 294

Human   386 VLTADFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKA 450
            |:..::..|..:.|..|:...|::..:|...|.:..|.|:|::..:|.||||||:||||...|..
pombe   295 VMVTEWADGIPLYDQTALSEAGMSKKEILTNLFRFLAFQMFHSKQVHCDPHPGNILVRKNQAGLC 359

Human   451 ELVLLDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQ- 514
            :.|:||||||.|..||.|.....|:.|....|..::.....|.|:....|||..::..|:...|
pombe   360 QTVILDHGLYVFESEKFRKEFALLFTAAYSLDKKSILQVMDAWGIGQPELFANRMLNIPMDEEQP 424

Human   515 LWGSHLLSREEAAYMVDMARERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMA 579
            ..|..::|::||.......|::|...:.....||:.:|::.|.:..::..|...|.||:...:||
pombe   425 HTGEKIISKKEAFQQQLAERKKFIGFLQDCTRLPKELLMLGRCLMLIQKNNQNFGYPVNSIAVMA 489

Human   580 KRA 582
            |.|
pombe   490 KVA 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK5	XP_011515209.1	AarF	202..>482	CDD:223733	90/285 (32%)
ADCK5	XP_011515209.1	ADCK1-like	243..483	CDD:270871	75/245 (31%)
SPAC10F6.14c	NP_593265.1	AarF	46..535	CDD:223733	118/393 (30%)
SPAC10F6.14c	NP_593265.1	ADCK1-like	149..403	CDD:270871	77/255 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	102	1.000	Domainoid score	I2051
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H34378
Inparanoid	1	1.050	183	1.000	Inparanoid score	I1292
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5641
SonicParanoid	1	1.000	-	-		X4477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.750