DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCK5 and adck5

DIOPT Version :9

Sequence 1:	XP_011515209.1	Gene:	ADCK5 / 203054	HGNCID:	21738	Length:	654	Species:	Homo sapiens
Sequence 2:	XP_031760516.1	Gene:	adck5 / 100127866	XenbaseID:	XB-GENE-6454664	Length:	582	Species:	Xenopus tropicalis

Alignment Length:	590	Identity:	358/590 - (60%)
Similarity:	439/590 - (74%)	Gaps:	28/590 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    79 VQLCHFHSALLHSRQKPWPSPAVFFRRNVRGLPPR-FSSPT---------PLWRKVLSTAVVG-- 131
            |.||.:|.:.| ||.:..       .:.:.|||.| |.|.|         |..|::|...::|
Frog     7 VLLCRYHISQL-SRCRTG-------EKILMGLPLRGFCSRTQGVEGLERRPPPRRMLRRLIIGSA 63

Human   132 --APLLLGARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYL 194
              ||.|....|..:|.:|:||||:::.|:|||.|||.:|.|||:||||.::|.|||.:||||.|.
Frog    64 LAAPPLGTLLYYGSEPQERRRMRILLQGIGRFWRSLMIGSQISVDYWWTSHVTLRGEDENSPRYE 128

Human   195 EVMSACHQRAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDEL 259
            ..||.|||||||.||.||:.|||||||||||||:||||||||||:||||||||||.|...||:||
Frog   129 AAMSRCHQRAADQLVEGAVQNGGLYVKLGQGLCAFNHLLPPEYTKTLRVLEDRALPRRPNEVNEL 193

Human   260 FLEDFQALPHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLR 324
            |||||.|....||..||.:|||||||||||||.||:||.|||||||||||||||||:.|||||||
Frog   194 FLEDFGAPAEHLFLHFDQKPIAAASLAQVHRATLHNGTDVAVKVQYIDLRDRFDGDLKTLELLLR 258

Human   325 LVEVMHPSFGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTA 389
            |:|.|||:|||||||:||||||:|||||||||||:|||||:|...|||.|||||||::|||||||
Frog   259 LIEFMHPTFGFSWVLKDLKGTLSQELDFENEGRNSERCARDLQSLPYVTVPRVHWDRTSKRVLTA 323

Human   390 DFCAGCKVNDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVL 454
            |:|.||||:.||.|:.|||.|.|.|||||:.||||||||||||:|||||||||.|||||||:|||
Frog   324 DYCEGCKVSSVEGIKEQGLDVRDAAEKLIQVFAEQIFYTGFIHADPHPGNVLVTKGPDGKAQLVL 388

Human   455 LDHGLYQFLEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSH 519
            ||||||::|.::||.:||:|||:|:||:...|..|:|.|||:||.||.|:|:|||:.:....||
Frog   389 LDHGLYEYLSKRDRTSLCKLWRSIVLRNRQDMEKHSAELGVKDYFLFCEILLQRPLSVPGAMGS- 452

Human   520 LLSREEAAYMVDMARERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRAVR 584
            .|:|||..||.|||||.|:.:|.|||.||||||||.||:||||.::|:||||.||:.|||:.||:
Frog   453 ALTREETRYMQDMAREHFDDIMRVLRALPRPMLLVFRNLNTVRCLHVSLGAPADRHILMARSAVK 517

Human   585 GWSRLAGATYRGVYGTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLSLVPPAEELY 649
            ||.||||....||     .|...|.||..|||:|||.::|.:|:|:.|.|.|:...::...|::.
Frog   518 GWRRLAGQNSLGV-----TRWISVTWESFKFELALRWDSLVLRVTSSLLRLLIRFQVIEHNEQME 577

Human   650 QYLET 654
            .:|::
Frog   578 TFLQS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK5	XP_011515209.1	AarF	202..>482	CDD:223733	216/279 (77%)
ADCK5	XP_011515209.1	ADCK1-like	243..483	CDD:270871	182/239 (76%)
adck5	XP_031760516.1	ADCK1-like	177..428	CDD:270871	185/250 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	329	1.000	Domainoid score	I8187
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	696	1.000	Inparanoid score	I5383
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		oto159021
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4477
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.050