DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCK5 and adck5

DIOPT Version :9

Sequence 1:	XP_011515209.1	Gene:	ADCK5 / 203054	HGNCID:	21738	Length:	654	Species:	Homo sapiens
Sequence 2:	NP_001189455.1	Gene:	adck5 / 100001584	ZFINID:	ZDB-GENE-081104-149	Length:	579	Species:	Danio rerio

Alignment Length:	581	Identity:	353/581 - (60%)
Similarity:	444/581 - (76%)	Gaps:	16/581 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    79 VQLCHFHSALLHSRQKP-WPSPAVFFRRNVRGLPPRFSSPT-----PLWRKVLSTAVVGAPLLLG 137
            ::||..|.:||  |:.| ..:|.||.:        :|||..     .|:||:|....||.||::|
Zfish     9 LRLCRHHMSLL--RKCPRLIAPQVFHQ--------KFSSNRVVKGHRLFRKLLLGVSVGVPLVVG 63

Human   138 ARYVMAEAREKRRMRLVVDGMGRFGRSLKVGLQISLDYWWCTNVVLRGVEENSPGYLEVMSACHQ 202
            .:||::|.||:|:|:::.:|:|||.|||.|||.||.||||.:|:.|||::|:||.:|:.||||||
Zfish    64 VQYVVSEPRERRKMKMLTEGIGRFCRSLYVGLMISADYWWTSNIALRGMDESSPEFLKQMSACHQ 128

Human   203 RAADALVAGAISNGGLYVKLGQGLCSFNHLLPPEYTRTLRVLEDRALKRGFQEVDELFLEDFQAL 267
            |||..:|.|||.|||||:|||||||:|||||||||.:||.||||:||.|.::|||.||.|||...
Zfish   129 RAASNMVDGAIQNGGLYIKLGQGLCAFNHLLPPEYIQTLHVLEDKALNRRYKEVDALFQEDFNMT 193

Human   268 PHELFQEFDYQPIAAASLAQVHRAKLHDGTSVAVKVQYIDLRDRFDGDIHTLELLLRLVEVMHPS 332
            |.::|:.|||:|:|||||||||:|:|||||.||||||||||||||||||.|||:||.:::.||||
Zfish   194 PDKMFRTFDYEPVAAASLAQVHKAELHDGTPVAVKVQYIDLRDRFDGDIRTLEILLDVIKFMHPS 258

Human   333 FGFSWVLQDLKGTLAQELDFENEGRNAERCARELAHFPYVVVPRVHWDKSSKRVLTADFCAGCKV 397
            |||.||||||||||||||||||||||:||||.||.||.:||||:|.||.:|||||||::|.|||:
Zfish   259 FGFRWVLQDLKGTLAQELDFENEGRNSERCAEELKHFKFVVVPKVFWDVTSKRVLTAEYCDGCKI 323

Human   398 NDVEAIRSQGLAVHDIAEKLIKAFAEQIFYTGFIHSDPHPGNVLVRKGPDGKAELVLLDHGLYQF 462
            |:||.|:.|||::.|.|:|||:.||||||||||||:||||||||||:|||.||||||||||||:.
Zfish   324 NNVEEIQRQGLSLKDTADKLIRIFAEQIFYTGFIHADPHPGNVLVRRGPDKKAELVLLDHGLYEH 388

Human   463 LEEKDRAALCQLWRAIILRDDAAMRAHAAALGVQDYLLFAEMLMQRPVRLGQLWGSHLLSREEAA 527
            |.:.||||||||||||||||||.|:.:|..|||::|.||:|||:|||:.:..|...::|:.||.:
Zfish   389 LSKSDRAALCQLWRAIILRDDAGMKTYANQLGVKEYFLFSEMLLQRPINMWDLGLGNILTGEETS 453

Human   528 YMVDMARERFEAVMAVLRELPRPMLLVLRNINTVRAINVALGAPVDRYFLMAKRAVRGWSRLAGA 592
            ||.|||..||:.:|.||:.:|||||||.|||||||.||:.|||||||||:|||.||||..|....
Zfish   454 YMRDMAINRFDKIMQVLKSMPRPMLLVFRNINTVRCINITLGAPVDRYFIMAKCAVRGHGRAQAE 518

Human   593 TYRGVYGTSLLRHAKVVWEMLKFEVALRLETLAMRLTALLARALVHLSLVPPAEELYQYLE 653
            ..|.....|:.|.....||.||||.|||.|...|.:|..|.:.|...::|...::::|||:
Zfish   519 DIRLFSRLSVFRWVCSFWESLKFEFALRSEMALMSVTRSLLKLLAFCNMVTLDQDVFQYLK 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCK5	XP_011515209.1	AarF	202..>482	CDD:223733	209/279 (75%)
ADCK5	XP_011515209.1	ADCK1-like	243..483	CDD:270871	179/239 (75%)
adck5	NP_001189455.1	AarF	78..499	CDD:223733	290/420 (69%)
adck5	NP_001189455.1	ADCK1-like	169..420	CDD:270871	184/250 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343424
Domainoid	1	1.000	328	1.000	Domainoid score	I6518
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34378
Inparanoid	1	1.050	706	1.000	Inparanoid score	I4222
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG56770
OrthoDB	1	1.010	-	-		D155590at7742
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		oto50116
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	1	1.100	-	-	LDO	PTHR43173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5641
SonicParanoid	1	1.000	-	-		X4477
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300