Protein Alignment ENPEP and SP1029

DIOPT Version :10

• Sequence 1: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_652618.1
• Gene: SP1029 / 53473
• FlyBaseID: FBgn0263236
• Length: 932
• Species: Drosophila melanogaster
• Alignment Length: 935
• Identity: 304/935 - (32%)
• Similarity: 482/935 - (51%)
• Gaps: 100/935 - (10%)

Human    80 ASEDESGQ-----WKNFRLPDFVNPVHYDLHVKPLLE--ED-TYTGTVSISINLSAPTRYLWLHL 136
            |:.|.|..     :..:|||..:.|..|.|.:..|||  || .::|:|.|.|.....|:.:.||.
  Fly    16 ATADSSADSIETTYNYYRLPTSLRPQKYHLRILTLLENPEDLRFSGSVKILIEALENTKNVTLHS 80

Human   137 RETRITRLPELKRPSGDQVQVRRCFE----YKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLN 197
            :...|.......|..|.:.:...|..    ....::.::...:||...:   .|.|.|.||..||
  Fly    81 KNLTIDESQITLRQIGGEGKKENCVSSTAVNPSHDFYILNTCQELLAGN---TYELYMPFAADLN 142

Human   198 GSLVGFYRTTYTE--NGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMP 260
            ..|.|:||::|.:  ....|.|..|..||..||.:|||||||:.||.:.:::.:.|:|.|:||||
  Fly   143 RQLEGYYRSSYKDPVANLTKWISVTQFEPASARLAFPCFDEPDFKAPFVVTLGYHKKYTAISNMP 207

Human   261 VAK----EESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTI--------YVQP 313
            ..:    |...|..|..  |::|||||||||.::|:.|        |.||.|:        :.:|
  Fly   208 EKETKPHETLADYIWCE--FQESVPMSTYLVAYSVNDF--------SHKPSTLPNSALFRTWARP 262

Human   314 EQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKE 378
            ......:|||.....|..|:|::|.:.:.|||:|:||:|||..||||||||:||||..|||....
  Fly   263 NAIDQCDYAAQFGPKVLQYYEQFFGIKFPLPKIDQIAVPDFSAGAMENWGLVTYREIALLYSAAH 327

Human   379 SASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLE 443
            |:.:::||||:||||||.||||||:|||.||.|||||||||::...|||.:...:|:..:|..|.
  Fly   328 SSLADKQRVASVVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLGVENINPEWRSMEQESLS 392

Human   444 DVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEK 508
            ::|.:...|:|.|||||...:....||:..||.|||.|||::|||:..::..|:|:.|.|.||:|
  Fly   393 NLLTIFRRDALESSHPISRPIQMVSEISESFDQISYQKGSTVLRMMHLFLGEESFRSGLQAYLQK 457

Human   509 YQFKNAKTSDFWAALEEASR----LP----VKEVMDTWTRQMGYPVLNVN-----GVKNITQKRF 560
            :.:|||:..:.|.:|.:|:.    ||    :|.:||:||.|.||||:||.     ....:.|:|:
  Fly   458 FSYKNAEQDNLWESLTQAAHKYRSLPKSYDIKSIMDSWTLQTGYPVINVTRDYAARTAKLNQERY 522

Human   561 LLDPRANPSQPPSDLGYTWNIPVKWT-----EDNITSSVLFNRSEKEGITLNSS---NPSGNAFL 617
            ||    |.....:..|..|.:|:.:|     :.|.|:...:....|.|.:|..:   .|..:.::
  Fly   523 LL----NTQVARAYRGGCWWVPLSYTTQAVQDFNNTAPKAWMECGKNGESLPKTIQDLPGPDQWV 583

Human   618 KINPDHIGFYRVNYEVATWD-SIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTK 681
            ..|......|:|||:...|. .|.|..:.:.:.....:||.|||||..||.....||::|:.|.:
  Fly   584 IFNTQLSTLYKVNYDAQNWKLLIETLTNGDFERIHVINRAQLIDDALYLAWTGEQDYEIAMRLIE 648

Human   682 YLKREENFLPWQRVISAVTYIISMFEDDKEL---------YPMIEEYFQGQVKPIADSL-GWNDA 736
            ||:||..:|||:          |.||:.|.:         :...:.|.:..:.||.:.| |.||.
  Fly   649 YLQREREYLPWK----------SAFENLKRVGRIVRQTPDFEFFKRYMKKLILPIYEHLNGINDT 703

Human   737 GDHVTK----LLRSSVLGFACKMGDREALNNASSLFEQWL-----NGTVSLPVNLRLLVYRYGMQ 792
            ...:.:    ||::.|:.:||:....:.:..|.:.:..|.     :....:|:|:|..||...::
  Fly   704 FSAIPQQDQVLLKTMVVNWACQYQVGDCVPQALAYYRNWRAEANPDEKNPVPINVRSTVYCTSIK 768

Human   793 NSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKD-TNLIKTQDVFTVIRY 856
            : |::..|.:...:|:|:::|.||..:|..|...:.|.||.|||:|..| ...|:.||.....:.
  Fly   769 H-GSDSDWEFLWTRYKKSNVAAEKRTILTALGCSREVWLLQRYLELTFDPKEAIRKQDSMWAFQA 832

Human   857 ISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVT-IAEPFNTELQLWQMESFFAKYPQAGA 920
            :::|..|..:|..:...|.|::...|....:::.|::: ::|...|.....:.:.|.....|:..
  Fly   833 VAFNEVGFLLAKKYFMDNVDFIYKFYHPLTKDMSRLLSPLSEQVITLSDFNEFKDFVNNSRQSLK 897

Human   921 G-EKPREQVLETVKNNIEWLKQHRN 944
            | |:..:|.||.:..|::|  :.||
  Fly   898 GLEQAIQQTLEIMLTNVQW--KERN 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83		1/2 (50%)
		M1_APN-Q_like	100..540	CDD:341064	183/468 (39%)
		ERAP1_C	616..934	CDD:463368	87/340 (26%)
SP1029	NP_652618.1	M1_APN-Q_like	42..497	CDD:341064	183/467 (39%)
		ERAP1_C	582..910	CDD:463368	87/338 (26%)