Protein Alignment ENPEP and CG42335

DIOPT Version :10

• Sequence 1: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_732655.3
• Gene: CG42335 / 42558
• FlyBaseID: FBgn0259237
• Length: 924
• Species: Drosophila melanogaster
• Alignment Length: 923
• Identity: 226/923 - (24%)
• Similarity: 393/923 - (42%)
• Gaps: 129/923 - (13%)

Human    90 NFRLPDFVNPVHYDLHVKPL---LEEDTYTGTVSISINL--SAPTRYLWLHLRETRITRLPELKR 149
            ::||...|.|.||:|.:..|   :|...:.|.|||::.:  :...:.:.||.....||.. .|..
  Fly    24 DYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQIILHADTLDITEC-WLLD 87

Human   150 PSGDQVQV----RRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTE 210
            .:|.||:.    |..:|...|: |.|...|...|...   |.|..::.|.:...:.||:..:|.|
  Fly    88 AAGAQVEAIDISRLIYEAATQQ-VRVPLTEAAQPGKN---YTLGFKYTGHIRTDMAGFFSASYVE 148

Human   211 --NGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTR 273
              ....:.:..|..:..:||...||||||..||.:.:.|..|..|.:::|..:.:.:::......
  Fly   149 RDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQIVRPNGYQSIANTKLKETKALSQDRFV 213

Human   274 TTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFA 338
            ..|:::..|||||:.|.|..:.:    ..:.....:..:||.....|::.::.:.|...:.|.|.
  Fly   214 DHFKETPVMSTYLLAFMVANYSA----RGNESEFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQ 274

Human   339 MNYS---LPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESAS-SNQQRVATVVAHELVHQW 399
            ..|:   ...|...:.|.|....|||||||.|.:..|:.:|..|.. |:::....::|||..|.|
  Fly   275 SPYAELGNDVLQYASSPRFPHNGMENWGLIIYSDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMW 339

Human   400 FGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPII--- 461
            ||:.||..||...||||.||.::|:...:....|:.:.:|.::..:..:...|:...:.|:.
  Fly   340 FGDSVTFSWWSYFWLNEAFARYYEYFMAHQLYPDYHLDEQFVVRQMQLIFGTDAQNGTQPMTSPE 404

Human   462 VTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEA 526
            ..:.||.:|...|.||:|:||:.|:||..:.:..|||....:.||::|...|....:.:..|.|
  Fly   405 SEIQTPSQIAYKFSGIAYAKGACIVRMWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFE- 468

Human   527 SRLPVKEVMD------TWTRQMGYPVLNV-----NGVKNITQKRFLL--DPRANPSQPPSDLGYT 578
             ..|..:.:|      .:|.|:|||::.|     |.|..:.|.||||  |..:|     :.|.||
  Fly   469 -HWPKNQDVDLVDFLTDYTEQVGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSN-----ATLKYT 527

Human   579 WNIPVKWTED------NITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWD 637
              :|:.:|.:      |:|.....:::... :.|:.::|..  ::..|.....:.||.|:....:
  Fly   528 --VPITFTTNLERDFYNLTPYKYLHKTVNV-LWLDFTSPID--WILFNLRQSNYQRVFYDDTLRE 587

Human   638 SIATALS-LNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTY 701
            .:..|:| .||......:||.:|||.|..|:||.:||.......:||.:|..::||..|...:..
  Fly   588 GLLLAISATNHSGIPVENRAQIIDDLFNFAQAQYVDYADVFRFLEYLAKEVEYVPWYAVYENLNT 652

Human   702 IISMFEDDKELYPMIEEYFQGQVKPIADSL--GWNDAGDHVTKLLRSSVLGFACKMGDREALNNA 764
            :....  ..|..|....|.......:.:.|  |||.....:....|:.::.:.|:.   :|.|..
  Fly   653 VAKRL--TPEQLPDFRIYLSSITAAVFEKLGVGWNAQDTPLDVANRNKLIKWLCRY---QASNCR 712

Human   765 SSLFEQWLNG-TVSLPVNLRLLVYRYGMQNSGNEISWN-YTL--EQYQKTSLAQEKEKL------ 819
            ..:..|::.| .|..|      .||.....:.:...:| ||:  .||...:...||..|
  Fly   713 PKVNVQFVTGHEVPSP------DYRETFYCAASGADYNSYTMLWGQYYLENRTSEKNMLWAAISC 771

Human   820 ------------LYGLASV--KNVTLLSRYLDLLKDTNLIKTQDVFTV----IRYISYNSYGKNM 866
                        :.|..||  |.:.:...|     :.|....|.:|.:    |..::||.    .
  Fly   772 TRDYETHYHKMIISGTESVEQKKIGIARMY-----EENPDLVQAIFEMITENIMELAYNF----Q 827

Human   867 AWNWIQLNWDYLVNRYTLNNRNLGRIVT-IAEPFNT-ELQLWQMESFFAKYPQAGAGEKPREQVL 929
            :|:                  :...::. :||.|.| |.|....|.:::.:...|..|:...:.|
  Fly   828 SWS------------------DTAEVINDMAEYFTTREQQQLLKEFYYSNHQFFGESEELLSKSL 874

Human   930 ETVKNNIEWLKQH 942
            .||:.|:.|.:.|
  Fly   875 VTVEKNLNWAETH 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83
		M1_APN-Q_like	100..540	CDD:341064	121/463 (26%)
		ERAP1_C	616..934	CDD:463368	74/350 (21%)
CG42335	NP_732655.3	M1_APN-Q_like	34..487	CDD:341064	121/463 (26%)
		ERAP1_C	566..878	CDD:463368	73/349 (21%)