Protein Alignment ENPEP and CG8774

DIOPT Version :10

• Sequence 1: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_650274.2
• Gene: CG8774 / 41635
• FlyBaseID: FBgn0038136
• Length: 942
• Species: Drosophila melanogaster
• Alignment Length: 919
• Identity: 357/919 - (38%)
• Similarity: 531/919 - (57%)
• Gaps: 75/919 - (8%)

Human    75 QDICPASEDESGQWK---------NFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTR 130
            ||.....|:.||:.:         ::|||..:.|.||:|:..|.||...:||...|||.:...|.
  Fly    41 QDKIDVFEEWSGESRTRMKREDTTDYRLPTNLVPTHYELYWHPDLETGNFTGQQRISIKVVEATN 105

Human   131 YLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQ-EYVVVEAEEELTPSSGDGLYLLTMEFAG 194
            .:.||.....||.:..|.|      :|.: ||.::: :::::...|||   :.|....|.:.|.|
  Fly   106 QIILHSYLLDITSVYVLNR------EVEK-FELEEERQFLIITLTEEL---AVDASITLGIIFGG 160

Human   195 WLNGSLVGFYRTTY-TENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPK-EYGALS 257
            .:...|||.|.:|| .|.|..::|..|..|||.||::|||||||..|||:.|::.||. .|.|:|
  Fly   161 QMKDKLVGLYSSTYLNEAGATRTISTTKFEPTYARQAFPCFDEPAMKATFAITVVHPSGSYHAVS 225

Human   258 NMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDS---VKRISNSGKPLTI--YVQPEQKH 317
            ||...:...:.| :|...||.||.|||||||..|..|.|   ..:.:..|:..::  |....|.:
  Fly   226 NMQQTESNYLGD-YTEAIFETSVSMSTYLVCIIVSDFASQSTTVKANGIGEDFSMQAYATSHQIN 289

Human   318 TAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASS 382
            ..|:|....::|.:|:.:|:.:.|.|.|||..|||||.:||||:|||:|||||.|||||..|:::
  Fly   290 KVEFALEFGQAVTEYYIQYYKVPYPLTKLDMAAIPDFASGAMEHWGLVTYRETALLYDPSYSSTA 354

Human   383 NQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLP 447
            |:|.:|..:|||:.||||||:|||.||.|||||||||.:.::.|||....||.|.:|..:..:.|
  Fly   355 NKQSIAGTLAHEIAHQWFGNLVTMKWWNDLWLNEGFARYMQYKGVNAVHPDWGMLEQFQIVALQP 419

Human   448 VQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFK 512
            |...|:.:|||||:..|.:|||||::||.|||.||.|::||||..:..|.|::....||.|:||.
  Fly   420 VLLYDAKLSSHPIVQKVESPDEITAIFDTISYEKGGSVIRMLETLVGAEKFEEAVTNYLVKHQFN 484

Human   513 NAKTSDFWAALEE-ASRLPVKEVMDTWTRQMGYPVLNVNGVKN----ITQKRFLLDPRANPSQPP 572
            |..|.||...:|. .:.|.:|::|.|||.|||||||||:.|.:    :||:|||.:| |:..:.|
  Fly   485 NTVTDDFLTEVEAVVTDLDIKKLMLTWTEQMGYPVLNVSKVADGSFKVTQQRFLSNP-ASYEEAP 548

Human   573 SD--LGYTWNIPVKW-TEDNITSSVLFNRS-EKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEV 633
            ||  .||.|::|:.| .:|...:|.:::.. :..||.:    ||...::|:|.:..|:||||||.
  Fly   549 SDSAYGYKWSVPITWFADDGSENSFIYDYDVDSVGIAV----PSEVQWIKLNVNQTGYYRVNYEE 609

Human   634 ATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISA 698
            :.|..:...|:.:...|..|||..|::||||||.|..|.||:.|::|.||.:|.:|:||
  Fly   610 SLWALLIQQLTTSPARFEIADRGHLLNDAFALADANQLSYKIPLDMTAYLAQERDFVPW------ 668

Human   699 VTYIIS----------MFEDDKELYPMIEEYFQGQVKPIADSLGWN-DAGDHVTKLLRSSVLGFA 752
              |:.|          ||   .|.|.....|.:..:..:.:.:||. ||.:|:...||.|:|..|
  Fly   669 --YVASNKLRSLHRSLMF---SEGYVSYLTYARSLIAGVYEEVGWTVDADNHLKNRLRVSILTAA 728

Human   753 CKMGDREALNNASSLFEQWLNGTVSLP-VNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEK 816
            |.:|..:.|..||..|..:|....:.| .:||.:||.||||.|.::.||:...:.:...:.|.||
  Fly   729 CALGVPDCLQQASERFSTFLENPTTRPSPDLREIVYYYGMQQSTSQSSWDQLFQLFVAETDASEK 793

Human   817 EKLLYGLASVKNVTLLSRYL-DLL----KDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWD 876
            .||:|||:.|:|    |:|| |.|    .|.:::::||.||.::||:.|..|:.:.|.:.:..|.
  Fly   794 LKLMYGLSGVRN----SQYLFDFLAQASSDESIVRSQDYFTCVQYIAANPVGEPVVWEFYREQWP 854

Human   877 YLVNRYTLNNRNLGRIVT-IAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLK 940
            .|..|:.|||||.||::. |...|.:.::|.:::.||:|||::|||...|.:.:||:|.|||||.
  Fly   855 QLTTRFGLNNRNFGRLIAQITANFASSVKLEEVQHFFSKYPESGAGANSRLEAVETIKYNIEWLS 919

Human   941 QHRNTIREW 949
            ::...|.:|
  Fly   920 RNEADITDW 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83		2/7 (29%)
		M1_APN-Q_like	100..540	CDD:341064	189/448 (42%)
		ERAP1_C	616..934	CDD:463368	119/335 (36%)
CG8774	NP_650274.2	M1_APN-Q_like	75..513	CDD:341064	189/448 (42%)
		ERAP1_C	592..912	CDD:463368	119/334 (36%)