Protein Alignment ENPEP and CG8773

DIOPT Version :10

• Sequence 1: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_650273.2
• Gene: CG8773 / 41634
• FlyBaseID: FBgn0038135
• Length: 994
• Species: Drosophila melanogaster
• Alignment Length: 946
• Identity: 364/946 - (38%)
• Similarity: 544/946 - (57%)
• Gaps: 57/946 - (6%)

Human    38 GLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICP---ASEDESG-----QWKNFRLP 94
            |.|.|..|:.:.|....|..:..|.|||||.      ..:.|   ||..|.|     :..::|||
  Fly    66 GSTASPGSTAEPGSTAEPGSTAEPGSTASPG------STVTPGSTASTSEPGTTASPEKIDYRLP 124

Human    95 DFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRR 159
            ..:.|.||||::.|.:|...::|..:|:|.:...|..:.||.....|:.: .:.....|.:::..
  Fly   125 GTLKPTHYDLYLFPNIETGEFSGQETITITVEEATDQIVLHSLNLNISSV-SIMNTGSDTLEILE 188

Human   160 CFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATD-HE 223
            ......:|:::.:..|.||......|::   .|.|.:...:||.|.::|.:..:.:..:||. .|
  Fly   189 TTVDAVREFLIFQLNEPLTKGRTVRLHI---GFEGSMANKIVGLYSSSYVKEDETRKWIATSKFE 250

Human   224 PTDARKSFPCFDEPNKKATYTISITHP--KEYGALSNMPVAKEESVDD-KWTRTTFEKSVPMSTY 285
            ||.||::|||||||..||.:||::.||  ::|.|||||.|  :.||.. .:...||.||||||||
  Fly   251 PTYARQAFPCFDEPALKAEFTITLVHPSGEDYHALSNMNV--DSSVSQGAFQEVTFAKSVPMSTY 313

Human   286 LVCFAVHQFDSVKRISNSGK------PLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLP 344
            |.||.|..| :.|::|...|      .:::|..|||....:.|..|.|.|.:|:.:||.:.|.||
  Fly   314 LACFIVSDF-AYKQVSIDTKGIGETFSMSVYATPEQLDKVDLAVTIGKGVIEYYIDYFQIAYPLP 377

Human   345 KLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWW 409
            |||..|||||.:||||:|||:|||||:||||...|:::|:||:|:|:|||..|.||||:|||:||
  Fly   378 KLDMAAIPDFVSGAMEHWGLVTYRETSLLYDEATSSATNKQRIASVIAHEFAHMWFGNLVTMNWW 442

Human   410 EDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVF 474
            .|||||||||||.|:|||:....:|:||||..:..:..|...|..:.|||||.||..||:||.:|
  Fly   443 NDLWLNEGFASFVEYLGVDAVYPEWKMRDQFTVSTLHSVLTLDGTLGSHPIIQTVENPDQITEIF 507

Human   475 DGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEAS-RLPVKEVMDTW 538
            |.|:||||||::|||||::....|::....||.:|::..|:|.:|:..:::.. ...|.|:|.||
  Fly   508 DTITYSKGSSLVRMLEDFLGETTFRQAVTNYLNEYKYSTAETGNFFTEIDKLELGYNVTEIMLTW 572

Human   539 TRQMGYPVLNVNGVKN----ITQKRFLLDPR-ANPSQPPSDLGYTWNIPVKW--TEDNITSSVLF 596
            |.|||.||:.:..|.:    :||||||.:|. .:....||:..|.|:||:.:  :.|::...:.|
  Fly   573 TVQMGLPVVTIEKVSDTEYKLTQKRFLSNPNDYDADHEPSEFNYRWSIPITYFTSSDSVVQRLWF 637

Human   597 NRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDD 661
            ...:.| ||:  :.|:...::|.|.|.:|:|||||:...|:.:|..|.:....|.|.|||.|::|
  Fly   638 YHDQSE-ITV--TVPAAVEWIKFNADQVGYYRVNYDTDLWNDLADQLVVQPSAFGSVDRAHLLND 699

Human   662 AFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVT------YIISMFEDDKELYPMIEEYF 720
            |||||.:..|.|..|..||:||.:|.:::||....|.:|      |..|       .|...::|.
  Fly   700 AFALADSTQLPYATAFELTRYLDKETDYVPWSVAASRLTSLKRTLYYTS-------TYAKYKKYA 757

Human   721 QGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLP-VNLRL 784
            ...::||..:|.|....||:...||.:.|..||.:|....|..|...|..||......| .::|.
  Fly   758 TALIEPIYTALTWTVGEDHLDNRLRVTALSAACSLGLESCLTEAGEQFNAWLAKPEDRPKADVRE 822

Human   785 LVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQD 849
            .||.||:|:.|::..|:...|.:...|.|.||.||:|||::::...:|.||:||..:...::.||
  Fly   823 TVYYYGIQSVGSQEDWDAVWELFVNESDASEKSKLMYGLSAIQIPWILQRYIDLAWNEEYVRGQD 887

Human   850 VFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIV-TIAEPFNTELQLWQMESFFA 913
            .||.:.|||.|..|:::.|::::.||..||:|:.||.|.||.:: :|...|:|:.:|.:||.|||
  Fly   888 YFTCLTYISANPVGESLVWDYVRENWQRLVDRFGLNERYLGNLIPSITARFSTQTKLEEMEQFFA 952

Human   914 KYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949
            |||:||||...|.:.||||||||.||.::...:..|
  Fly   953 KYPEAGAGTAARVRALETVKNNIVWLAENLEGVDAW 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83		12/41 (29%)
		M1_APN-Q_like	100..540	CDD:341064	188/450 (42%)
		ERAP1_C	616..934	CDD:463368	122/325 (38%)
CG8773	NP_650273.2	KLF9_13_N-like	<17..118	CDD:425361	17/57 (30%)
		M1_APN-Q_like	130..573	CDD:341064	187/449 (42%)
		ERAP1_C	654..973	CDD:463368	122/325 (38%)