Protein Alignment ENPEP and CG3502

DIOPT Version :10

• Sequence 1: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_611781.3
• Gene: CG3502 / 37695
• FlyBaseID: FBgn0046253
• Length: 912
• Species: Drosophila melanogaster
• Alignment Length: 923
• Identity: 238/923 - (25%)
• Similarity: 415/923 - (44%)
• Gaps: 119/923 - (12%)

Human    88 WKNFRLPDFVNPVHYDLHVKPLLE--EDTYTGTVSISINLSAPTRYLWLH-----LRETRITRLP 145
            ::::|||..|.|:||:|.:...|.  :..:.|:|:|.:.....|:.:.||     :.|.|.:.:.
  Fly    25 YEDYRLPRSVEPLHYNLRILTHLNSTDQRFEGSVTIDLLARETTKNITLHAAYLKIDENRTSVVS 89

Human   146 ELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTE 210
            ..::...::::|.     :...:.::....||..   |.:|.|.|.|...||.|..|:|::.||:
  Fly    90 GQEKFGVNRIEVN-----EVHNFYILHLGRELVK---DQIYKLEMHFKAGLNDSQSGYYKSNYTD 146

Human   211 --NGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVD----- 268
              ..:|..:..|...||.||::|||||||:.|||:.|::.:.|:|..||.|||.:.:..|
  Fly   147 IVTKEVHHLAVTQFSPTFARQAFPCFDEPSWKATFNITLGYHKKYMGLSGMPVLRCQDHDSLTNY 211

Human   269 -----DKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIY---VQPEQKHTAEYAANI 325
                 |...||        |||||.||||..::.....:......|:   :||:.......:..|
  Fly   212 VWCDHDTLLRT--------STYLVAFAVHDLENAATEESKTSNRVIFRNWMQPKLLGQEMISMEI 268

Human   326 TKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATV 390
            ...:..::|..|.:|:.|.|:|::.:|.....|||||||:||.|..|..:..:.....:...|..
  Fly   269 APKLLSFYENLFQINFPLAKVDQLTVPTHRFTAMENWGLVTYNEERLPQNQGDYPQKQKDSTAFT 333

Human   391 VAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLM 455
            ||||..||||||:|||:||.||||.||.:::|.:|.::..:.:|:..::.:..|:......||..
  Fly   334 VAHEYAHQWFGNLVTMNWWNDLWLKEGPSTYFGYLALDSLQPEWRRGERFISRDLANFFSKDSNA 398

Human   456 SSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFW 520
            :...|...|..|.|:...|....|.|||..:|||...:..|.|..|.:.:||::.|.|...:|.|
  Fly   399 TVPAISKDVKNPAEVLGQFTEYVYEKGSLTIRMLHKLVGEEAFFHGIRSFLERFSFGNVAQADLW 463

Human   521 AALEEA--------SRLPVKEVMDTWTRQMGYPVLNV-----NGVKNITQKRFLLDPRANPSQPP 572
            .:|:.|        |...:...||:||.|.|||::.:     .|...:.|.||..:.....:..
  Fly   464 NSLQMAALKNQVISSDFNLSRAMDSWTLQGGYPLVTLIRNYKTGEVTLNQSRFFQEHGIEKASS- 527

Human   573 SDLGYTWNIPVKWTEDNITSSVLFNRSEKE---GITLNS------SNPSGNAFLKINPDHIGFYR 628
                 .|.:|:::...|:..   ||::..:   ...||:      .:.|.:.::.:||.....:|
  Fly   528 -----CWWVPLRFVRQNLPD---FNQTTPQFWLECPLNTKVLKLPDHLSTDEWVILNPQVATIFR 584

Human   629 VNYEVATWDSIATAL--SLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLP 691
            |||:...|..|..:|  ..|.......::|.|:||..|||..:|..|..|.:|.:|||:|::|||
  Fly   585 VNYDEHNWRLIIESLRNDPNSGGIHKLNKAQLLDDLMALAAVRLHKYDKAFDLLEYLKKEQDFLP 649

Human   692 WQR---VISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSL----GWNDAGDHVTKL-LRSSV 748
            |||   :::.:..::::.|.:|     .:.|.|..:.|:.:..    |..:|...:..: .....
  Fly   650 WQRAIGILNRLGALLNVAEANK-----FKNYMQKLLLPLYNRFPKLSGIREAKPAIKDIPFAHFA 709

Human   749 LGFACKMGDREALNNASSL-FEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSL 812
            ...||:....:..:.|..| ......|.:.||.:.:.:.| ..:.:.|.:..:......:|.::.
  Fly   710 YSQACRYHVADCTDQAKILAITHRTEGQLELPSDFQKVAY-CSLLDEGGDAEFLEVFGLFQNSTN 773

Human   813 AQEKEKLLYGLASVKNVTLLSRYLD--------LLKDTNLIKTQD-------VFTVIRYISYNSY 862
            ..::..|...|..|:|.....::|:        ||.|..::..:.       |.....||.  |:
  Fly   774 GSQRRILASALGCVRNFGNFEQFLNYTLESDEKLLGDCYMLAVKSALNREPLVSPTANYII--SH 836

Human   863 GKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQ 927
            .|.:...:.:.....|:.....|.|:...|..:      :.||..::.|          |:|.::
  Fly   837 AKKLGEKFKKKELTGLLLSLAQNLRSTEEIDRL------KAQLEDLKEF----------EEPLKK 885

Human   928 VLETVKNNIEWLK 940
            .|...|.|.:|.|
  Fly   886 ALYQGKMNQKWQK 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83
		M1_APN-Q_like	100..540	CDD:341064	141/469 (30%)
		ERAP1_C	616..934	CDD:463368	71/343 (21%)
CG3502	NP_611781.3	M1_APN-Q_like	37..491	CDD:341064	141/469 (30%)
		ERAP1_C	572..887	CDD:463368	70/338 (21%)