Protein Alignment ENPEP and CG7653

DIOPT Version :10

• Sequence 1: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_001356886.1
• Gene: CG7653 / 34935
• FlyBaseID: FBgn0028935
• Length: 710
• Species: Drosophila melanogaster
• Alignment Length: 663
• Identity: 173/663 - (26%)
• Similarity: 293/663 - (44%)
• Gaps: 119/663 - (17%)

Human    92 RLPDFVNPVHYDLHVKPLLEED---TYTGTVSISINLSAPTRYLWLH-----LRETRITRLPELK 148
            |||..|.|.|||:.:...||..   :|||.|.|||:....|..:.||     :...:||...|.
  Fly    43 RLPAKVKPFHYDIRLLTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITLFGET- 106

Human   149 RPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFA-----------------GWL 196
                ...::|.......::|:||...:.|.....   |:|::||.                 .|.
  Fly   107 ----SNYRLRSVRFNNDRKYMVVTFNQSLLMGKS---YVLSVEFGRPMTMDQRDGYFIRHYINWK 164

Human   197 NGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPV 261
            ....:.:..:.:..|.              .|.:.|.||||:.|||:.:::.|.|.:.:..||.|
  Fly   165 TSEKIWYSVSHFNRNW--------------IRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKV 215

Human   262 ----AKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTI--YVQPEQKHTAE 320
                ...|..|..|:......::|  |:|:.|:|:.|:.....:.|..|:..  ..|........
  Fly   216 QAVLPNREIQDYVWSVHEVTPTIP--THLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATS 278

Human   321 YAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQ 385
            :||.:...:.::.:....:...|.|:|::.:.||.|.||||:||:.||..:||.  :|....:::
  Fly   279 FAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLL--REDGPMSKE 341

Human   386 RVAT--VVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMR-------DQML 441
            ::.|  ::|||:.|.||.|::.||.:.||||.||.|.:|:.|.|:|.::....|       ..|:
  Fly   342 KLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMM 406

Human   442 LE------DVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQK 500
            .|      .::|:..:.||.:...:                  |.|.:|:..||..::..|.|..
  Fly   407 YESQVGGISLVPLSSNASLNAETQL------------------YQKATSLTSMLIGFLGNETFYD 453

Human   501 GCQMYLEKYQFKNAKTSDFWAALEEASR--------LPVKEVMDTWTRQMGYPVLNV--NGVKNI 555
            |.|.::.:..|.::....||.:|:.||.        ..||.:|||||.|.|||::.|  ||.:..
  Fly   454 GLQRHMWQNSFGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVF 518

Human   556 TQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEK-------EGITLNSSNPSG 613
            .::...|:..::         :.|.||:.:..:.  .|:..|...|       .||.||...|.
  Fly   519 LKQGHALNRSSS---------HLWWIPLTYLIEG--GSLSKNLKPKAWLSPNSHGIKLNDIVPR- 571

Human   614 NAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALN 678
            |.::.:|...:|:|||||:..||..:||.|..:.::.:..:||.::.|...|....||.:..|||
  Fly   572 NQWILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALN 636

Human   679 LTKYLKREENFLP 691
            :.||:..|:.:.|
  Fly   637 VLKYIIDEDEYEP 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83
		M1_APN-Q_like	100..540	CDD:341064	122/493 (25%)
		ERAP1_C	616..934	CDD:463368	25/76 (33%)
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	121/491 (25%)
		ERAP1_C	574..>652	CDD:463368	25/76 (33%)
		dnaA	630..>701	CDD:455861	7/20 (35%)