DRSC/TRiP Functional Genomics Resources

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Protein Alignment ENPEP and CG40470

DIOPT Version :10

Sequence 1:NP_001968.3 Gene:ENPEP / 2028 HGNCID:3355 Length:957 Species:Homo sapiens
Sequence 2:NP_001036635.1 Gene:CG40470 / 3355093 FlyBaseID:FBgn0058470 Length:941 Species:Drosophila melanogaster


Alignment Length:941 Identity:217/941 - (23%)
Similarity:401/941 - (42%) Gaps:139/941 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    92 RLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPS---GD 153
            |||..|.|:.|::.::|.::...:.|::.:.:.....::.::.|..:|.:..:.::...:   ||
  Fly    52 RLPKEVLPLSYEVLIEPHMDNQNFEGSIRMHLRWIGDSKKVYFHAHDTLLIDVSQINLTTLNMGD 116

Human   154 -----QVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQ 213
                 .|.:.|.....::...|:..::::...|.   .||.:.|.|.::.:..|.:|:.||.:|.
  Fly   117 GTLDKNVIILRGVRLPRKPVFVLYLKDKIKKGSE---CLLDIYFQGNISETEEGLFRSYYTNSGN 178

Human   214 --VKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPV--------AKEESVD 268
              .:..:||:.:|.:||:.|||||||..|..:.:||..||.|..|.|.|:        .:..|:|
  Fly   179 DGEEIYLATNLKPNNARRLFPCFDEPGIKVPFNVSIARPKGYITLFNTPLHNTINHPKLRSYSLD 243

Human   269 DKWTRTTFEKSVPMSTYLVCFAV---HQFDSVKRISNSGKP--------------LTIYVQPEQK 316
                  .|..:.||||:...|.:   |.::..|.:.:|..|              |.|..:....
  Fly   244 ------FFHTTAPMSTHAFGFVILKLHMWNEHKIVKSSDIPAINIWSNNLSSTNLLDIQNKLNVA 302

Human   317 HTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGT-GAMENWGLITYRETNLLYDPKESA 380
            ||.             .:.:|.:...|.|||.||||...| ..:...|::..||:.:|       
  Fly   303 HTT-------------IQHFFNIPLPLTKLDVIAIPSLATLPFISASGILIARESEIL------- 347

Human   381 SSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDV 445
                ::....::.||::||.|..:|.:||.|..:|:...||                  :..|.|
  Fly   348 ----KKDVFEISRELIYQWIGIWITPEWWTDANVNKALISF------------------IASEIV 390

Human   446 LPVQEDDSLMSSHPIIVTVTTPDEIT-----SVFDGISYS----KGSSILRMLEDWIKPENFQKG 501
            ..:.........:|:.:..:...|::     |...||.:.    |...|:|||...:....|:.|
  Fly   391 FEINGGIEFNGKYPMTILYSLYYELSKRYPNSHITGIKHEFASIKVQLIIRMLSLTVGKYTFRLG 455

Human   502 CQMYLEKYQFKNAKTSDFWAALEEASR--------LPVKEVMDTWTRQMGYPVLNV----NGVKN 554
            .|.::..|:||..|:||||.|:...::        |.:..:.::|......|::.:    :....
  Fly   456 IQSFICDYKFKTYKSSDFWNAITTQAKADNSLDSDLSILSIAESWLEHSRLPLVTIIRDYDSETA 520

Human   555 ITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSV---LFNRSEKEGITLNSSNPSGNAF 616
            |.|::..|..|.:  ..|......|.||:.....:..|.|   .|....|....|.|:.||.|.|
  Fly   521 IVQQKVYLRERLH--DVPDQDNMLWWIPIALKRQDSLSFVNTGSFKWMNKTRQMLISNLPSKNMF 583

Human   617 LKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSA--DRASLIDDAFALARAQLLDYKVALNL 679
            :.:|.:.||.:.|||:...|:.::..|....|..|..  .||.|:.||:.||.|..|::..|||:
  Fly   584 IIVNEEEIGPFPVNYDDNNWNMLSKYLRTEEKRESIPVYTRAKLLHDAWNLAYAGELNFSTALNV 648

Human   680 TKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGD--HVTK 742
            |.:||.|.|.:.|..|.:.:..:....| ...:....|.|....:.|:.:.||.....:  ::|:
  Fly   649 TLFLKYERNHIVWSPVFTFLDQVGKRLE-KSSINKKFELYIIELLAPLYEYLGTAHFNEDINITE 712

Human   743 LLRSSVLGFACKMGDREALNNASSLFEQWLNGT-----VSLPVNLRLLVYRYGMQNSGNEISWNY 802
             ||.....|.||.|.......|...|..|:|.:     ..:|......::::|...     .|.:
  Fly   713 -LRKLTTSFLCKAGYFPCFKEARRAFNIWINSSFPNFETPVPNEYICSIFKWGSMK-----EWMF 771

Human   803 TLE---QYQKTSLAQEKE---KLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNS 861
            .|:   ::.|:.:..::.   |:|.|..:.::...:...|.:||:.::....|...:|..::..|
  Fly   772 GLDRLCEFPKSRIQSDRTHLLKMLAGCPAQRDKIFILLELAILKNISIFSDTDKMLIISTVTSRS 836

Human   862 YGKNMAWNWIQLNWDYLVNRYTLNNRNL-GRIVTIAE-PFNTELQLWQMESFFAK-YPQAGAGEK 923
            .|.....:::..|||.:.::: .||.|: .::::.|. .|:|:.....::.|:.: |...|..:.
  Fly   837 IGYTTLLDFLSNNWDDIHHKF-YNNTNIWTKLISSATGMFSTQEGYDLVKKFYDEHYGHFGRAQH 900

Human   924 PREQVLETVKNNIEWLKQHRNTIREWFFNLL 954
            ..|:.|..:|..|:|.||:...|.||..:.|
  Fly   901 IIEKSLRNIKEGIQWSKQNIPVIEEWIDHYL 931

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ENPEPNP_001968.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 44..83
M1_APN-Q_like 100..540 CDD:341064 109/492 (22%)
ERAP1_C 616..934 CDD:463368 76/335 (23%)
CG40470NP_001036635.1 GluZincin 60..502 CDD:472708 109/492 (22%)
ERAP1_C 583..910 CDD:463368 76/334 (23%)
Blue background indicates that the domain is not in the aligned region.

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