Protein Alignment ENPEP and CG31445

DIOPT Version :10

• Sequence 1: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_651689.1
• Gene: CG31445 / 326140
• FlyBaseID: FBgn0051445
• Length: 927
• Species: Drosophila melanogaster
• Alignment Length: 937
• Identity: 307/937 - (32%)
• Similarity: 479/937 - (51%)
• Gaps: 111/937 - (11%)

Human    87 QWKNFRLPDFVNPVHYDLHVKPLLEED---TYTGTVSISINLSAPTRYLWLH-----LRETRITR 143
            ::.::|||..:.|..|.|.:..|||..   .:.|.|.|.|.....||.:.||     :.|:|||
  Fly    23 RYNHYRLPTALRPQRYYLRILTLLESPDDLRFAGNVQIVIKALQNTRNITLHSKNLTIDESRIT- 86

Human   144 LPELKRPSG--------DQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSL 200
               |::.||        ....|....:|    |:....:|.|    ...:|.|.:.|:..|...|
  Fly    87 ---LRQISGAGNMDNCVSSTSVNPTHDY----YIFHTCKELL----AGNVYKLFLPFSADLTPQL 140

Human   201 VGFYRTTYTE--NGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAK 263
            .|:||::|.:  ..:.:.:.||..||:.|||:|||||||..||::.:::.:.|::.|||||||.:
  Fly   141 FGYYRSSYKDPVTNKTRWLSATQFEPSSARKAFPCFDEPGFKASFVVTLGYHKQFNALSNMPVRE 205

Human   264 ----EESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTI--------YVQPEQK 316
                |...:..|..  |::|||||||||.::|:.|        |.||.|:        :.:|...
  Fly   206 IRPHESLANYIWCE--FQESVPMSTYLVAYSVNDF--------SFKPSTLPNGALFRTWARPNAI 260

Human   317 HTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESAS 381
            ...:|||.....|..|:||:|.:.|.|||:|::|:|||..||||||||:.|||:.|||.|..|:.
  Fly   261 DQCDYAAEFGPKVLQYYEEFFGIRYPLPKIDQMAVPDFSAGAMENWGLVKYRESTLLYSPTHSSL 325

Human   382 SNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVL 446
            :::|.:|.|:||||.||||||:|||.||.|||||||||::...|||.....:|..||:..|..::
  Fly   326 ADKQDLANVIAHELAHQWFGNLVTMKWWTDLWLNEGFATYVAGLGVQEIYPEWHSRDKGSLTALM 390

Human   447 PVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQF 511
            .....|||:|||||...:....||...||.|||.|||::|||:..::..|:|:.|.:.||:.|.:
  Fly   391 TAFRLDSLVSSHPISRPIQMVTEIEESFDAISYQKGSAVLRMMHLFMGEESFRTGLREYLKLYAY 455

Human   512 KNAKTSDFWAALEEASR----LP----VKEVMDTWTRQMGYPVLNV-----NGVKNITQKRFLLD 563
            |||:.::.|.:|..|:.    ||    :..:||:||.|.|:||||:     .|...|||:|:|
  Fly   456 KNAEQNNLWESLTTAAHQNGALPGHYDINTIMDSWTLQTGFPVLNITRDYSTGTAEITQERYL-- 518

Human   564 PRANPSQPPSDLGYTWNIPVKWT-----EDNITSSVLFNR--SEKEGITLNSSNPSG-NAFLKIN 620
              .|...|.:|....|.:|:.:|     :.|.||...:..  |..||:.....:.:| ..:|.:|
  Fly   519 --RNSQIPQADRVGCWWVPLSYTTQDENDFNNTSPKAWMECSSTDEGVPTTIDHSAGPEEWLILN 581

Human   621 PDHIGFYRVNYEVATWDSIATALSLNHKTFSS---ADRASLIDDAFALARAQLLDYKVALNLTKY 682
            ......|:.||:...|..:..  :||.|.|.|   .:||.||||....|.....||:.||.:|.|
  Fly   582 IQLSTPYKANYDARNWKLLID--TLNSKDFQSIHVINRAQLIDDVLYFAWTGEQDYETALQVTNY 644

Human   683 LKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSL-GWNDAGDHVTK---- 742
            |:||.:.:||:..:..:..:..:...... :...:.|.|..:.||.:.| |.||....:|:
  Fly   645 LRRERDLIPWKSALDNLKLLNRILRQTPN-FGSFKRYMQKLLTPIYEHLHGMNDTFSLMTQQDEV 708

Human   743 LLRSSVLGFACKMGDREALNNASSLFEQWLNGT-----VSLPVNLRLLVYRYGMQNSGNEISWNY 802
            ||:::|:..||:....:.:..|.:.|.:|...|     ..:|:|||..||...: :.|.|..||:
  Fly   709 LLKTTVVNVACQYDVSDCVTQAQAYFRRWRAETNPDENHPVPLNLRSTVYCTAI-SQGTEEDWNF 772

Human   803 TLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLD-LLKDTNLIKTQDVFTVIRYISYNSYGKNM 866
            ...:|:|:::|.|::.:|..|...|.|.:|.||:: .....:.|:.||.....:.::....|..:
  Fly   773 LWSRYRKSNVASERQTILSTLGCSKEVWILQRYMEKSFHPKSAIRKQDSSLCFQAVASREVGFLL 837

Human   867 AWNWIQLNWDYLVNRYTLNNRNLGRIVT-IAEPFNTELQLWQMESF------FAKYPQAGAGEKP 924
            |..:...|.:.:...|....|.:.|::| ::|..:|...|.:..||      |.|     ...:.
  Fly   838 AKQYFIENVELIHKYYYPQTRVMSRLLTPLSEQVSTINDLNKFRSFANDSRHFLK-----GIRQA 897

Human   925 REQVLETVKNNIEWL--KQHR--NTIR 947
            .:|.|||:..|::|:  ..|:  .|||
  Fly   898 MQQSLETMLTNVQWMDWNYHKFSRTIR 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83
		M1_APN-Q_like	100..540	CDD:341064	182/477 (38%)
		ERAP1_C	616..934	CDD:463368	89/338 (26%)
CG31445	NP_651689.1	M1_APN-Q_like	37..492	CDD:341064	182/476 (38%)
		ERAP1_C	577..905	CDD:463368	88/336 (26%)