Protein Alignment ENPEP and CG2111

DIOPT Version :10

• Sequence 1: NP_001968.3
• Gene: ENPEP / 2028
• HGNCID: 3355
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_572644.1
• Gene: CG2111 / 31995
• FlyBaseID: FBgn0030223
• Length: 931
• Species: Drosophila melanogaster
• Alignment Length: 922
• Identity: 242/922 - (26%)
• Similarity: 427/922 - (46%)
• Gaps: 117/922 - (12%)

Human    92 RLPDFVNPVHYDLHVKPLLEE--DTYTGTVSISINLSAPTRYLWLHLRETRI--TRLPELKRPSG 152
            |||.::.|:.|.:.:...:.:  ..:.|||.|.:.....|:.:.|:..:..|  .|...|...:|
  Fly    25 RLPKWLVPLSYRVDIVTRINQPYQPFGGTVVIDLRSERSTKRIVLNAHDLAIGKRRAVTLSDKNG 89

Human   153 DQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKS- 216
            :.|.|.......|...:.|..:.   |...:..|.:.:.|...|.....|||.:.|.::....:
  Fly    90 NSVPVSSIQMDIKLSRLTVSLKR---PLKVNVTYSMRVAFTSVLRNDNTGFYSSNYVDHNTTLTQ 151

Human   217 -IVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPV---AKEESVDD-KWTRTTF 276
             :.||..||..||::|||||:|..:..:.|::.||..|.|||||||   .:..|:.| .||:  |
  Fly   152 WLAATQFEPNHAREAFPCFDDPIFRTPFKINLAHPYLYRALSNMPVQRTIRHASLKDYVWTQ--F 214

Human   277 EKSVPMSTYLVCFAVHQFDSVKRISN--SGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAM 339
            .:|.||.||||.|.:.:||.....|:  |..|::.:.:|:.....|:|..:...:..::|:.|..
  Fly   215 VESHPMQTYLVAFMISKFDRPGFTSSERSDCPISTWARPDALSQTEFANMVVAPLLSFYEDLFNS 279

Human   340 NYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIV 404
            .|...|:|.:|:|||...:.|||||..:.|.:||||.:.|:..:||.||..||..:|:|||||:|
  Fly   280 TYRQKKIDLVALPDFTFKSKENWGLPAFAEESLLYDSQRSSIDDQQGVARAVAMMVVNQWFGNLV 344

Human   405 TMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDE 469
            ::.||.::||...||.:....||:....:|..:::..|:..|.|.:.|:.:::.  :||.:.|||
  Fly   345 SVAWWHEIWLKNVFALYLSRFGVHSLRPEWDYQERHALQLYLSVLDYDAHVNTD--LVTASVPDE 407

Human   470 --ITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALE-EASR--- 528
              |.:.::.|...|.:.:..||...:..|.:....:.||..|..:.|.:||||..|: :..|
  Fly   408 SHIWAAYNEIGERKAAVLFEMLHRVMGEEAWLTALRRYLVVYANRTATSSDFWDLLQLQVDRNGR 472

Human   529 ----LPVKEVMDTWTRQMGYPVLNVNGVKN-------ITQKRFLLDPR------ANPSQPPSDLG 576
                |.:..:|..|..|.|||::.|  .:|       ::|:||.:.|:      .||
  Fly   473 LGKGLNITRIMKCWLGQPGYPLVTV--TRNYDHRTAIVSQQRFFITPQFRNRWARNP-------- 527

Human   577 YTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNA--------------FLKINPDHIGFY 627
             .|.:|:.:|..:...|.:.:.|  ..:|..:|.||..:              ::..|..|...:
  Fly   528 -CWWVPLSYTCPSCQHSEIISFS--RWLTCPTSKPSSKSNTVLLEKLEAEPTDWILFNVQHTAPF 589

Human   628 RVNYEVATWDSIATALS------LNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKRE 686
            ||||::..|..:...|:      |.|:    .:||.|:||.|:||.:..::|.:||.:..||:.|
  Fly   590 RVNYDLRNWQLLNKTLADPNKFRLIHR----VNRAQLVDDLFSLAWSGDIEYDMALGILGYLEHE 650

Human   687 ENFLPWQRVISAVTY-IISMFEDDKELYPMIEEY----FQGQVKPIADSLGWNDAGD--HVTKLL 744
            :.|:.|  |.:.::: .|:........|.:.:.|    .:.|.|.:..|...:.:|:  |
  Fly   651 DEFVVW--VATEISFERINNVAKSNPNYLIFKTYMRLLLERQFKRVISSDLTSSSGNMTH----- 708

Human   745 RSSVLGFACKMGDREALNNASSLFEQWLNGTVS----LPVNLRLLV----YRYGMQNSGNEISWN 801
            |..::..||   :.|.....|....:::.||..    :.:..|..|    .::|.:...:.:.
  Fly   709 RPVIIRLAC---EYELPACVSLARREFMKGTPEKGGWMTIRERETVVCTAVKFGTEGDRDMVE-- 768

Human   802 YTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNM 866
               ..|::::.|.|||.||..||..:||..|.|.|....:::.::.|:.....:.:..||.|..:
  Fly   769 ---SMYKRSNFAAEKESLLTALACSRNVFALQRVLIWTFESSGVRKQNARRTFKAVVSNSMGYRL 830

Human   867 AWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEP----FNTELQLWQMESFFAK-YPQAGAGEKPRE 926
            |..::.:|...:.| |..|:.:  ::|.:..|    .:|..:|.....||.: .......|:..:
  Fly   831 AKKYVSVNMQNIRN-YCSNSTD--KVVNLMTPLIECLSTPKELLYFSKFFKEILRDMNGSERLIK 892

Human   927 QVLETVKNNIEW 938
            .:||...:||.|
  Fly   893 ILLERGNDNIHW 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..83
		M1_APN-Q_like	100..540	CDD:341064	137/461 (30%)
		ERAP1_C	616..934	CDD:463368	77/343 (22%)
CG2111	NP_572644.1	M1_APN-Q_like	33..487	CDD:341064	136/460 (30%)
		ERAP1_C	578..897	CDD:463368	76/340 (22%)