Protein Alignment Scnn1g and ppk26

DIOPT Version :9

• Sequence 1: NP_035456.1
• Gene: Scnn1g / 20278
• MGIID: 104695
• Length: 655
• Species: Mus musculus
• Sequence 2: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 620
• Identity: 133/620 - (21%)
• Similarity: 235/620 - (37%)
• Gaps: 178/620 - (28%)

Mouse    26 KDLMHWYCLNTNTHGCRRI-VVSRGRLRRLLWIA------FTLTAVALII---WQCALLVFSFYT 80
            |.::|.||..|..||.|.: ...|..|.||.||:      ||...:.|.|   |....::.||..
  Fly    68 KAIIHEYCDYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTCVKLTLNIWDKWNNNPVIVSFAE 132

Mouse    81 VSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALL----SLYGVKD-------V 134
            .|..:    .::.|||||:|.                :::|::.:.    |.:.|:|       :
  Fly   133 KSTPV----WQIPFPAVTVCP----------------ETKTRREIFNFTDSYHQVRDFQSNVSGI 177

Mouse   135 LDSTPRKRREAGSMRSTWEGTPPRFLNLIPLLVFNENEKG-KARDFFTGRKRKISGKIIH----- 193
            :|.:.:::...|::....|.      :|..:.:.|:..:| :..|..|..........::
  Fly   178 VDLSDKQKGLYGAVSQVCEP------HLHDVTLGNKTRRGMEIIDALTEVSPHFDDTYLNCKWRN 236

Mouse   194 ---KASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVP-----LE 250
               |.|::.|     |.|        |.|...::|:|...|  |.::...:     :|     .|
  Fly   237 SPVKCSDIFH-----KFV--------TEDGVCFSFNSLSPA--EIFRAEGI-----IPDFIFREE 281

Mouse   251 KKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYG-----NCYTFNNRENATILSTSMGGSEY 310
            .:::|.::.|        ||.|..| :.:.:.:.:.|     ..|.|            |||:|
  Fly   282 NRLSMDWNVE--------DGYSASA-DTSPYPNRVLGPGARAGLYLF------------MGGAE- 324

Mouse   311 GLQVILYINEDEY--NPFLVSSTGAKVLVH----------QQNEYPFIEDVGTEIETAMSTSIGM 363
                   |:.|:.  .|.    .|.|:|:|          |....||.::|...|...:.|:
  Fly   325 -------IDFDDMCRGPV----QGFKILLHTPGDVAQVSKQYFRIPFDQEVLISIRPKIITT--- 375

Mouse   364 HLTESFKLSEP-YSQC-TEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAA 426
              ::..|..|| ..|| .:...::...||    ||...|...|.....:.||||.::|.|.....
  Fly   376 --SDGLKHYEPNRRQCYFQKERELRYFNI----YSQSNCELECLANFTLTKCGCVKFSMPRNVNM 434

Mouse   427 NYCNYQQHPNWMYCYYQ-----LYQAF----------VREELGCQSVCKQSCSFKEWTLTTSLAQ 476
            ..|....    :.||.|     |.:.|          .|.|..|.  |..||        ||:|
  Fly   435 PVCGDAS----LKCYNQAEDELLLREFTQGLVNAGENTRGETECN--CLPSC--------TSIA- 484

Mouse   477 WPSEASE-----KWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSN 536
            :.:|.|:     |.::|..:.:..::.:|: ....::::.||:|:....:...|........|:|
  Fly   485 YEAEISQADFDYKTVINTDSPEGKEEQSKR-QGMKMSRVSIFFKEAQFLTSRRSELYGTTDFLAN 548

Mouse   537 FGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQ 571
            .||.|||:|..|::.::|:|....:...|.:..|:
  Fly   549 CGGLLGLFMGVSMLSIVELIYFCTVRLISNLRMRR 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scnn1g	NP_035456.1	ENaC	24..636	CDD:273304	133/620 (21%)
		deg-1	32..557	CDD:273309	128/598 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	582..636
ppk26	NP_648125.3	ASC	74..570	CDD:279230	129/599 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820