Protein Alignment Scnn1b and ppk26

DIOPT Version :9

• Sequence 1: NP_001258952.1
• Gene: Scnn1b / 20277
• MGIID: 104696
• Length: 638
• Species: Mus musculus
• Sequence 2: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 631
• Identity: 120/631 - (19%)
• Similarity: 221/631 - (35%)
• Gaps: 176/631 - (27%)

Mouse    13 RLQKGPGY-TYKELLVWYCNNTNTHGPKRIICEGPKKKAM-----WF--LLTLLFACLVC----- 64
            :::.|.|: ..|.::..||:.|..||.:.:   |.||:.:     |.  |:..:|.|:..
  Fly    57 QIKYGSGFQAAKAIIHEYCDYTTIHGIRYL---GEKKRPLLERLFWISVLVLSVFTCVKLTLNIW 118

Mouse    65 --WQWGVFIQTYLS-----WEVSVSLSMGFKTMNFPAVTVCNSSP-----FQYSKVKHLLKDLDE 117
              |.....|.::..     |::.           |||||||..:.     |.::...|.::|...
  Fly   119 DKWNNNPVIVSFAEKSTPVWQIP-----------FPAVTVCPETKTRREIFNFTDSYHQVRDFQS 172

Mouse   118 LMEAVL-----EKILAPEASHSNTTRTLNFTIWNHT--PLVLID---ERNPDHPVVLNLFGDSHN 172
            .:..::     :|.|....|........:.|:.|.|  .:.:||   |.:|.       |.|::.
  Fly   173 NVSGIVDLSDKQKGLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPH-------FDDTYL 230

Mouse   173 SSNPAPGSTCNAQGCKVAMRLCSANGTVCTLRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMG 237
            :                           |..||..           ::.::||.:.:.:|  |:.
  Fly   231 N---------------------------CKWRNSP-----------VKCSDIFHKFVTED--GVC 255

Mouse   238 YAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTE------ETLPSAN----PGTEFG 292
            ::.:.:..|.:|..|     ...|.|.....|....:|.:.:      :|.|..|    ||...|
  Fly   256 FSFNSLSPAEIFRAE-----GIIPDFIFREENRLSMDWNVEDGYSASADTSPYPNRVLGPGARAG 315

Mouse   293 LKLILDIGQEDYVPFL-ASTAGARLMLHE-------QRTY---PFIREEGIYAMAGTETSIGVLV 346
            |.|.:...:.|:.... ....|.:::||.       .:.|   ||.:|    .:......|....
  Fly   316 LYLFMGGAEIDFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRIPFDQE----VLISIRPKIITTS 376

Mouse   347 DKLQRKGEPYSP----CTMNGS-DVAIKNLYSVYNTTYSIQACLHSCFQDHMIRNCSCGHYLYPL 406
            |.|:.    |.|    |..... ::...|:||..|       |...|..:..:..|.|..:..|.
  Fly   377 DGLKH----YEPNRRQCYFQKERELRYFNIYSQSN-------CELECLANFTLTKCGCVKFSMPR 430

Mouse   407 PEGEKYCNNRDFPDWAYCYLNLQMSVTQRETCLSM--------------CKESCNDTQYKMTISM 457
            ......|.:....    ||...:..:..||....:              |..||....|:..||.
  Fly   431 NVNMPVCGDASLK----CYNQAEDELLLREFTQGLVNAGENTRGETECNCLPSCTSIAYEAEISQ 491

Mouse   458 ADWPSEASEDWILHVLSQERDQSSNITLSRKG--IVKLNIYFQEFNYRTIEESPANNIVWLLSNL 520
            ||:..:.       |::.:..:.......|:|  :.:::|:|:|..:.|...|........|:|.
  Fly   492 ADFDYKT-------VINTDSPEGKEEQSKRQGMKMSRVSIFFKEAQFLTSRRSELYGTTDFLANC 549

Mouse   521 GGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLVASCKGLRRRRPQ 566
            ||..|.:||.|:|.::|       .|:...::|:::.:..|:.|.:
  Fly   550 GGLLGLFMGVSMLSIVE-------LIYFCTVRLISNLRMRRKTRKE 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scnn1b	NP_001258952.1	ENaC	21..621	CDD:273304	118/622 (19%)
		deg-1	29..538	CDD:273309	112/584 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..620
ppk26	NP_648125.3	ASC	74..570	CDD:279230	114/594 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820