Protein Alignment Scnn1a and ppk26

DIOPT Version :9

• Sequence 1: NP_035454.2
• Gene: Scnn1a / 20276
• MGIID: 101782
• Length: 700
• Species: Mus musculus
• Sequence 2: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 653
• Identity: 125/653 - (19%)
• Similarity: 225/653 - (34%)
• Gaps: 209/653 - (32%)

Mouse    60 EPSEPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFW-AVLWLCTFGM 123
            :.||....|:::.......::.:.:...:|:.|||||...|...|...::..|| :||.|..|..
  Fly    46 DDSEDEVDTKKQIKYGSGFQAAKAIIHEYCDYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTC 110

Mouse   124 MYWQFAL-LFEEYFSYPVSLNINLNSD---KLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTL 184
            :  :..| :::::.:.||.::....|.   ::.|||||||       .|.|            |.
  Fly   111 V--KLTLNIWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVC-------PETK------------TR 154

Mouse   185 FDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKD 249
            .:::.:..||                               :..|..:|..|.:      ||..|
  Fly   155 REIFNFTDSY-------------------------------HQVRDFQSNVSGI------VDLSD 182

Mouse   250 WKIGF-----QLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEEALGSFIFT 309
            .:.|.     |:|..:..|     .:.|....|.      :.|:..|.:.||..::..|     .
  Fly   183 KQKGLYGAVSQVCEPHLHD-----VTLGNKTRRG------MEIIDALTEVSPHFDDTYL-----N 231

Mouse   310 CRFNQAPCNQANYSQFHHPMY---GNCYTFNNKNNSNLWMS---------------SM------- 349
            |::..:|   ...|...|...   |.|::||:.:.:.::.:               ||
  Fly   232 CKWRNSP---VKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMDWNVEDG 293

Mouse   350 ----------------PGVNNGLSLTLRTEQNDFIPLL-STVTGARVMVHGQDEPAFMDDGGFNV 397
                            ||...||.|.:...:.||..:. ..|.|.::::|...:.|.:....|.:
  Fly   294 YSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPVQGFKILLHTPGDVAQVSKQYFRI 358

Mouse   398 RPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSK----------------YTQQVCIH 446
            ....|..||:|.:.:.:..|             :|:..|::                |:|..|..
  Fly   359 PFDQEVLISIRPKIITTSDG-------------LKHYEPNRRQCYFQKERELRYFNIYSQSNCEL 410

Mouse   447 SCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTN 511
            .|.....:.||||.....|:...:..|...                   ||.|:::......:..
  Fly   411 ECLANFTLTKCGCVKFSMPRNVNMPVCGDA-------------------SLKCYNQAEDELLLRE 456

Mouse   512 YK---LSAGYSR--------WPSVKSQDWIFEMLSLQNNY--TIN----------NKRNG--VAK 551
            :.   ::||.:.        .||..|..:..|:.....:|  .||          :||.|  :::
  Fly   457 FTQGLVNAGENTRGETECNCLPSCTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQGMKMSR 521

Mouse   552 LNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRF 616
            ::|||||..:.|:..|........|:|.|....|:.|.|:||:||       |:....:.|:...
  Fly   522 VSIFFKEAQFLTSRRSELYGTTDFLANCGGLLGLFMGVSMLSIVE-------LIYFCTVRLISNL 579

Mouse   617 RSR 619
            |.|
  Fly   580 RMR 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Scnn1a	NP_035454.2	ENaC	80..677	CDD:273304	122/633 (19%)
		deg-1	88..600	CDD:273309	118/604 (20%)
ppk26	NP_648125.3	ASC	74..570	CDD:279230	119/611 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820