DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Scn9a and NaCP60E

DIOPT Version :9

Sequence 1:NP_001277603.1 Gene:Scn9a / 20274 MGIID:107636 Length:1984 Species:Mus musculus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2596 Identity:815/2596 - (31%)
Similarity:1166/2596 - (44%) Gaps:864/2596 - (33%)


- Green bases have known domain annotations that are detailed below.


Mouse    47 PKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNK---GKAIFRFNATPALYM 108
            |:..:.:|.|..||..:...|..|..:|||::|.:..: :||.|::|   ...|.||..|.:|::
  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFL 108

Mouse   109 LSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMSNPPDWTKNVEYTFTGIYTFESLIKILA 173
            ..|:||.||:.:.|..:..|...:|.|||.||||:.|:   :..:..||.|..||:.|.:|||:|
  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170

Mouse   174 RGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 238
            :||.:.::|:||:||||||||||...|.|..:.:||::.||||||||||||:|::||||||:.||
  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235

Mouse   239 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRK-------------DLEQNETLESIM 290
            :.|.::|::||.||:|||.||||..||::||.|::||.|:             .:..|:|...:.
  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLY 300

Mouse   291 STAESEEELKRYFYYLEGSKDALLCGFSTDSGQCPEGYECVTAGRNPDYGYTSFDTFGWAFLALF 355
                .|:||            .:|||..|.:..||..|.|:..|.||::|||:||.|.|:.|..|
  Fly   301 ----DEDEL------------PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTF 349

Mouse   356 RLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQ-- 418
            :|:|.|||||:|...|...|...:.||.||:|.||||||||:|||||::|||:.:...||.|:  
  Fly   350 QLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDL 414

Mouse   419 -------------KELEFQQMLDRLKKEQEEAEAIAAAAAEYTSLGRSRIMGLSE---------S 461
                         ..|..:::....||:.:..:.:..|:.......|.:..|..|         |
  Fly   415 LDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGS 479

Mouse   462 SSETSRLSS----------KSAKERRNRRKKKKQKLSSGEEKGDDEKLSKSGSEES--------- 507
            :.:.::..|          .||.||.:....:.||  ..::.....||:||||..|         
  Fly   480 NGDDNKSHSATPSPGPSPRHSATERPSALTMQAQK--QYQQMEQQHKLAKSGSGGSNNPMAPTPK 542

Mouse   508 --IRKKSFHLGVEGHHRAREKRLSTPNQ-SPLSIRGSLF--SARRSSRTSLFSFKGRGRDLGSET 567
              |..:...:||:           .||. .|...:|.|.  |.:.||.:|           |...
  Fly   543 GRISFQDSGMGVK-----------NPNMLYPSDYKGQLIANSGQPSSNSS-----------GVNR 585

Mouse   568 EFADDEHSIFGDNESRRGSLFVPH--------RPRERRSSNISQASRSPPVLPVNGKMHSAVDCN 624
            |.:.|:..:..|:|.:..:..:.|        .|||.|                      .:.||
  Fly   586 ESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVR----------------------LIKCN 628

Mouse   625 GVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAM 689
            |.::.:...:...| :.:...||::                                        
  Fly   629 GNIARIKNHNVYAL-HQEFSSEVVV---------------------------------------- 652

Mouse   690 SRASILTNTVEEL-EESRQKCPPWWYRFAHTFLIWNCSPY--WIKFKKFIYFIVMDPFVDLAITI 751
                     :::| :.:..:|..|            |:.|  |::|:..:|.:|.||..:||||:
  Fly   653 ---------IDDLPDRNCDRCVHW------------CTDYESWLQFQNCLYKVVRDPLFELAITL 696

Mouse   752 CIVLNTLFMAMEHHPMTDEFKNVLAVGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVT 816
            ||||||.|:|||||.|::.|:|.|.|||.|||.||..|.::||:|:.. ::|..||||||.||||
  Fly   697 CIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVT 760

Mouse   817 LSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 881
            .||:::....|:||||||..|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||
  Fly   761 ASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAV 825

Mouse   882 VGMQLFGKSYKECVCKINENCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQTMC 943
            :|||||.|.|..  .|.:.: .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|
  Fly   826 IGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTC 887

Mouse   944 LIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEE---------------------------- 980
            ..:::..:|:||.:||||||||||:||:|:.|.:.:|                            
  Fly   888 FAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKD 952

Mouse   981 ----------------------------------------------------------------- 980
                                                                             
  Fly   953 RKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDF 1017

Mouse   981 ----------------------------------------------------------------- 980
                                                                             
  Fly  1018 GFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGN 1082

Mouse   981 --------------------------------------------------DTD--ANNLQIAVAR 993
                                                              |||  ||:.:.....
  Fly  1083 GTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGS 1147

Mouse   994 IKRG--------------------INYVKQ----------------------------------- 1003
            ..||                    :.|.|.                                   
  Fly  1148 FNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMR 1212

Mouse  1004 -----------------------TLREFILKSFSKK-----------PKGSK-----DTKRTADP 1029
                                   .|||.:|....|:           .||:|     :..|:..|
  Fly  1213 RHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRP 1277

Mouse  1030 NNKRENYISNRTLAEISKDHN----FLKEKDKISGFSSSL------------------------- 1065
            :::. ....|.|:.|.|:..|    |.||.::|...::||                         
  Fly  1278 SSQM-GQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHI 1341

Mouse  1066 -------DKSFMDE-----NDYQS----------------------------------------- 1077
                   ::|..||     |.|.|                                         
  Fly  1342 AIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSI 1406

Mouse  1078 ----------------------------------------------------------------- 1077
                                                                             
  Fly  1407 SNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEV 1471

Mouse  1078 --------------------FIHNP---------------------------------------- 1082
                                |:|.|                                        
  Fly  1472 PEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPT 1536

Mouse  1083 ---------------SLTVTVPIA----------------------------------PGE---- 1094
                           ||..|.|:|                                  .|:    
  Fly  1537 SLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRM 1601

Mouse  1095 ----------SDLENMNTEELSS---DSDSDYS-----KERRNRSSSSEC--------------- 1126
                      :..::..||..||   |:.|..:     |..:::|::.:.               
  Fly  1602 EHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPW 1666

Mouse  1127 ----STVDNPLPG----EEEAEAEPIN---------ADEPEACFTDGCVRRF----PCCQVNIDS 1170
                |.||:...|    .:.|..:|:.         |..|:.||...|...|    |.....:|:
  Fly  1667 HCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDT 1731

Mouse  1171 GKGKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIF 1235
            ...|.|..:|.....:|:...||.|::::|..||..|.||||.::|.||:|.:|.:.:..|..||
  Fly  1732 QSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIF 1796

Mouse  1236 ILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALS 1300
            ::||:|||:|.|:..|||:.|..|||:||.||:.:|:...  ..:|..::|||||||||||||:|
  Fly  1797 VVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAIS 1859

Mouse  1301 RFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTDGSRFSVSQVANR 1365
            |::|||:|||||:.|||||.|||||||:||||||||||..|.|||::|||.. |....:::|.::
  Fly  1860 RWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEM-GELLPITEVNDK 1923

Mouse  1366 SECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSVNVNAQPIYEYNLY 1430
            .:|     :..|..|.|.|:.||:||:|||:|||||||:|||::|..|||:..|:.||..|.|||
  Fly  1924 WDC-----IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLY 1983

Mouse  1431 MYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG--QDIFMTEEQKKYYNAMKKLGSKKPQK 1493
            .||||||||:.||||||||||||||||||..|||..|  .::|:||.||.||.||||||.|||||
  Fly  1984 AYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQK 2048

Mouse  1494 PIPRPGNKFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTDYMSFVLYWINVVFIILFTG 1558
            .|.||.|.|....:||..::.|:|.|.|||.|||:||.:|...|...:.|:|...|..|..:|..
  Fly  2049 VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGL 2113

Mouse  1559 ECVLKLISLRHYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIK 1623
            |.::|::.||::||||.||:|||::|:.||.|:.:.:::....:||||.||:|:.||||||||||
  Fly  2114 EAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIK 2178

Mouse  1624 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMIC 1688
            .|||||.|||||::|||||||||.||.|:.|||||.|||.|..||.:..::||.||:|||.||..
  Fly  2179 AAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQL 2243

Mouse  1689 LFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMY 1753
            ||::.|||||:.:|..:: ..|||||| .:|  ....|:||:|.:.|.||.|:||||:::|:|||
  Fly  2244 LFRLMTSAGWNDVLESLM-IQPPDCDP-FIH--GHTNGNCGHPLLAITYFTSFIIISYMIVINMY 2304

Mouse  1754 IAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNK 1818
            ||:|||||:.|.:|....:.|||.||||..|.|:||.|||||.|.:||||.|:|||||.|:|||.
  Fly  2305 IAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNN 2369

Mouse  1819 VQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDS---LRSQMEERFMSANPSKVSYEPITT 1880
            |.|::.:||:..|::|||||||.|..|.|||...|.|:   |:.||:.:|....|::...|.:::
  Fly  2370 VALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSS 2434

Mouse  1881 TLKRKQEDVSATIIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLPNKEDIVFDNVNENSSP 1941
            |...|:::.:|..||..::.|..|:..|..|:    .|              |:..:.|||
  Fly  2435 TRIWKRQEKAAKTIQTGWKEYLRRKREKERSN----SG--------------DSATQTSSP 2477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Scn9aNP_001277603.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55 1/7 (14%)
I. /evidence=ECO:0000305 112..410 142/310 (46%)
Ion_trans 147..410 CDD:278921 127/275 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..540 22/112 (20%)
Na_trans_cytopl 487..606 CDD:288761 29/140 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..609 7/42 (17%)
II. /evidence=ECO:0000305 725..988 145/477 (30%)
Ion_trans 760..955 CDD:278921 104/197 (53%)
Na_trans_assoc 981..1185 CDD:284034 70/613 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1039 6/39 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1089..1145 17/134 (13%)
III. /evidence=ECO:0000305 1178..1486 168/309 (54%)
Ion_trans 1224..1464 CDD:278921 138/239 (58%)
Na_channel_gate 1456..1508 CDD:240441 31/53 (58%)
IV. /evidence=ECO:0000305 1495..1793 153/297 (52%)
Ion_trans 1530..1768 CDD:278921 123/237 (52%)
GPHH 1780..1835 CDD:293510 31/54 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1933..1984 4/9 (44%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 106/234 (45%)
Ion_trans 705..902 CDD:278921 106/200 (53%)
Ion_trans 1768..2019 CDD:278921 149/258 (58%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 124/238 (52%)
GPHH 2331..2386 CDD:293510 31/54 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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